NERVE AND REPOLARIZATION IMAGING IN SUDDEN CARDIAC DEATH
心源性猝死的神经和复极成像
基本信息
- 批准号:6640846
- 负责人:
- 金额:$ 42.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-06-01 至 2005-05-31
- 项目状态:已结题
- 来源:
- 关键词:alpha adrenergic receptor arrhythmia autoradiography beta adrenergic receptor bioimaging /biomedical imaging congenital heart disorder denervation developmental neurobiology disease /disorder model dogs electrocardiography gap junctions heart innervation postnatal growth disorder sudden cardiac death sympathetic nervous system
项目摘要
We recently demonstrated heterogeneous myocardial sympathetic
innervation in a colony of German shepherd dogs with ventricular arrhythmia and
sudden cardiac death. The proposed research will apply scintigraphic methods to
study the development of sympathetic nerves in these arrhythmic animals, and
determine the effects of altered nerve development on adrenergic receptors, gap
junctions, and repolarization responses. In Aim 1, we will study the postnatal
development of myocardial innervation and perfusion and compare the results to
the postnatal development of ventricular arrhythmias. The hypothesis to be
tested is that postnatal maturation of sympathetic innervation is delayed in
this colony of animals, and this delayed maturation is a primary determinant of
ventricular arrhythmia. In Aim 2, we will study the effects of modulation of
sympathetic nerve growth on the expression of ventricular arrhythmias. We will
test the hypothesis that modulation of sympathetic nerve growth, or induced
homogeneity of innervation will decrease the frequency and severity of
arrhythmias. In Aim 3, we will study effects of regional denervation on the
distribution of sympathetic nerve histology, myocyte gap junctions, and alpha
and beta adrenergic receptor density and affinity. We will test the hypothsosis
that heterogeneous spatial gradients of sympathic innervation result in
associated gradients in adrenergic receptors and gap junctions. Aim 4 will
study the developmental effects of sympathetic innervation on local myocardial
repolarization. The hypothesis to be tested is that heterogeneous innervation
results in local abnormalities of myocardial repolarization during the basal
state and during sympathetic stimulation. The unique opportunity to investigate
the development of cardiac sympathetic innervation and compare functional
abnormalities of the sympathetic nerves to myocardial perfusion, signal
transduction, intercellular communication and cardiacarrhythmia. These studies
may provide a more comprehensive understanding of the interaction of the
sympathetic nervous system and arrhythmogenesis.
我们最近证实了异质性心肌交感神经。
一群患有室性心律失常的德国牧羊犬的神经支配
心源性猝死。拟议的研究将应用闪烁照相方法来
研究这些心律失常动物的交感神经发育,以及
确定神经发育改变对肾上腺素能受体GAP的影响
交界处和复极反应。在目标1中,我们将研究出生后
心肌神经支配和心肌灌注的研究进展及其与
室性心律失常的出生后发展。假设是
试验表明,交感神经的出生后成熟延迟在
这群动物,以及这种延迟成熟是决定
室性心律失常。在目标2中,我们将研究调制的效果
交感神经生长对室性心律失常的表达。我们会
检验以下假设:交感神经生长的调节或诱导
神经支配的同质性将降低心绞痛的发生频率和严重程度
心律不齐。在目标3中,我们将研究区域去神经对
交感神经组织学、心肌细胞缝隙连接和α-受体的分布
以及β肾上腺素能受体密度和亲和力。我们将检验这一假设
交感神经分布的不同空间梯度导致
肾上腺素能受体和缝隙连接的相关梯度。目标4将
交感神经支配对局部心肌发育影响的研究
复极化。需要检验的假设是异质性神经支配
在基础状态下导致局部心肌复极异常
状态和交感神经刺激期间。独一无二的调查机会
心脏交感神经支配的发展及其功能比较
交感神经对心肌灌注、信号的异常
转导、细胞间通讯和心律失常。这些研究
可以更全面地了解
交感神经系统与心律失常发生。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Performance evaluation of a pinhole SPECT system for myocardial perfusion imaging of mice.
- DOI:10.1118/1.1521939
- 发表时间:2002-12
- 期刊:
- 影响因子:3.8
- 作者:Max C. Wu;B. Hasegawa;M. Dae
- 通讯作者:Max C. Wu;B. Hasegawa;M. Dae
Pinhole single-photon emission computed tomography for myocardial perfusion imaging of mice.
- DOI:10.1016/s0735-1097(03)00716-2
- 发表时间:2003-08
- 期刊:
- 影响因子:24
- 作者:Max C. Wu;D. Gao;R. Sievers;R. Lee;B. Hasegawa;M. Dae
- 通讯作者:Max C. Wu;D. Gao;R. Sievers;R. Lee;B. Hasegawa;M. Dae
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MICHAEL W DAE其他文献
MICHAEL W DAE的其他文献
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{{ truncateString('MICHAEL W DAE', 18)}}的其他基金
NERVE AND REPOLARIZATION IMAGING IN SUDDEN CARDIAC DEATH
心源性猝死的神经和复极成像
- 批准号:
6097424 - 财政年份:2000
- 资助金额:
$ 42.71万 - 项目类别:
NERVE AND REPOLARIZATION IMAGING IN SUDDEN CARDIAC DEATH
心源性猝死的神经和复极成像
- 批准号:
6537834 - 财政年份:2000
- 资助金额:
$ 42.71万 - 项目类别:
NERVE AND REPOLARIZATION IMAGING IN SUDDEN CARDIAC DEATH
心源性猝死的神经和复极成像
- 批准号:
6390750 - 财政年份:2000
- 资助金额:
$ 42.71万 - 项目类别:
NONINVASIVE ASSESSMENT OF CARDIAC ADRENERGIC INNERVATION
心脏肾上腺素神经支配的无创评估
- 批准号:
6109581 - 财政年份:1998
- 资助金额:
$ 42.71万 - 项目类别:
NONINVASIVE ASSESSMENT OF CARDIAC ADRENERGIC INNERVATION
心脏肾上腺素神经支配的无创评估
- 批准号:
6241702 - 财政年份:1997
- 资助金额:
$ 42.71万 - 项目类别:
RADIONUCLIDE IMAGING USING I 125 MIBG IN NEWBORN HEARTS
使用 I 125 MIBG 对新生儿心脏进行放射性核素成像
- 批准号:
2233781 - 财政年份:1996
- 资助金额:
$ 42.71万 - 项目类别:
RADIONUCLIDE IMAGING USING I 125 MIBG IN NEWBORN HEARTS
使用 I 125 MIBG 对新生儿心脏进行放射性核素成像
- 批准号:
2378866 - 财政年份:1996
- 资助金额:
$ 42.71万 - 项目类别:
RADIONUCLIDE IMAGING USING I 125 MIBG IN NEWBORN HEARTS
使用 I 125 MIBG 对新生儿心脏进行放射性核素成像
- 批准号:
2668752 - 财政年份:1996
- 资助金额:
$ 42.71万 - 项目类别:
NONINVASIVE ASSESSMENT OF CARDIAC ADRENERGIC INNERVATION
心脏肾上腺素神经支配的无创评估
- 批准号:
3470903 - 财政年份:1988
- 资助金额:
$ 42.71万 - 项目类别:
NONINVASIVE ASSESSMENT OF CARDIAC ADRENERGIC INNERVATION
心脏肾上腺素神经支配的无创评估
- 批准号:
3470901 - 财政年份:1988
- 资助金额:
$ 42.71万 - 项目类别:
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