NERVE AND REPOLARIZATION IMAGING IN SUDDEN CARDIAC DEATH
心源性猝死的神经和复极成像
基本信息
- 批准号:6097424
- 负责人:
- 金额:$ 42.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-06-01 至 2004-05-31
- 项目状态:已结题
- 来源:
- 关键词:alpha adrenergic receptor arrhythmia autoradiography beta adrenergic receptor bioimaging /biomedical imaging congenital heart disorder denervation developmental neurobiology disease /disorder model dogs electrocardiography gap junctions heart innervation postnatal growth disorder sudden cardiac death sympathetic nervous system
项目摘要
We recently demonstrated heterogeneous myocardial sympathetic
innervation in a colony of German shepherd dogs with ventricular arrhythmia and
sudden cardiac death. The proposed research will apply scintigraphic methods to
study the development of sympathetic nerves in these arrhythmic animals, and
determine the effects of altered nerve development on adrenergic receptors, gap
junctions, and repolarization responses. In Aim 1, we will study the postnatal
development of myocardial innervation and perfusion and compare the results to
the postnatal development of ventricular arrhythmias. The hypothesis to be
tested is that postnatal maturation of sympathetic innervation is delayed in
this colony of animals, and this delayed maturation is a primary determinant of
ventricular arrhythmia. In Aim 2, we will study the effects of modulation of
sympathetic nerve growth on the expression of ventricular arrhythmias. We will
test the hypothesis that modulation of sympathetic nerve growth, or induced
homogeneity of innervation will decrease the frequency and severity of
arrhythmias. In Aim 3, we will study effects of regional denervation on the
distribution of sympathetic nerve histology, myocyte gap junctions, and alpha
and beta adrenergic receptor density and affinity. We will test the hypothsosis
that heterogeneous spatial gradients of sympathic innervation result in
associated gradients in adrenergic receptors and gap junctions. Aim 4 will
study the developmental effects of sympathetic innervation on local myocardial
repolarization. The hypothesis to be tested is that heterogeneous innervation
results in local abnormalities of myocardial repolarization during the basal
state and during sympathetic stimulation. The unique opportunity to investigate
the development of cardiac sympathetic innervation and compare functional
abnormalities of the sympathetic nerves to myocardial perfusion, signal
transduction, intercellular communication and cardiacarrhythmia. These studies
may provide a more comprehensive understanding of the interaction of the
sympathetic nervous system and arrhythmogenesis.
我们最近证实了异质心肌交感神经
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MICHAEL W DAE其他文献
MICHAEL W DAE的其他文献
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{{ truncateString('MICHAEL W DAE', 18)}}的其他基金
NERVE AND REPOLARIZATION IMAGING IN SUDDEN CARDIAC DEATH
心源性猝死的神经和复极成像
- 批准号:
6640846 - 财政年份:2000
- 资助金额:
$ 42.71万 - 项目类别:
NERVE AND REPOLARIZATION IMAGING IN SUDDEN CARDIAC DEATH
心源性猝死的神经和复极成像
- 批准号:
6537834 - 财政年份:2000
- 资助金额:
$ 42.71万 - 项目类别:
NERVE AND REPOLARIZATION IMAGING IN SUDDEN CARDIAC DEATH
心源性猝死的神经和复极成像
- 批准号:
6390750 - 财政年份:2000
- 资助金额:
$ 42.71万 - 项目类别:
NONINVASIVE ASSESSMENT OF CARDIAC ADRENERGIC INNERVATION
心脏肾上腺素神经支配的无创评估
- 批准号:
6109581 - 财政年份:1998
- 资助金额:
$ 42.71万 - 项目类别:
NONINVASIVE ASSESSMENT OF CARDIAC ADRENERGIC INNERVATION
心脏肾上腺素神经支配的无创评估
- 批准号:
6241702 - 财政年份:1997
- 资助金额:
$ 42.71万 - 项目类别:
RADIONUCLIDE IMAGING USING I 125 MIBG IN NEWBORN HEARTS
使用 I 125 MIBG 对新生儿心脏进行放射性核素成像
- 批准号:
2233781 - 财政年份:1996
- 资助金额:
$ 42.71万 - 项目类别:
RADIONUCLIDE IMAGING USING I 125 MIBG IN NEWBORN HEARTS
使用 I 125 MIBG 对新生儿心脏进行放射性核素成像
- 批准号:
2378866 - 财政年份:1996
- 资助金额:
$ 42.71万 - 项目类别:
RADIONUCLIDE IMAGING USING I 125 MIBG IN NEWBORN HEARTS
使用 I 125 MIBG 对新生儿心脏进行放射性核素成像
- 批准号:
2668752 - 财政年份:1996
- 资助金额:
$ 42.71万 - 项目类别:
NONINVASIVE ASSESSMENT OF CARDIAC ADRENERGIC INNERVATION
心脏肾上腺素神经支配的无创评估
- 批准号:
3470903 - 财政年份:1988
- 资助金额:
$ 42.71万 - 项目类别:
NONINVASIVE ASSESSMENT OF CARDIAC ADRENERGIC INNERVATION
心脏肾上腺素神经支配的无创评估
- 批准号:
3470901 - 财政年份:1988
- 资助金额:
$ 42.71万 - 项目类别:
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