NERVE AND REPOLARIZATION IMAGING IN SUDDEN CARDIAC DEATH

心源性猝死的神经和复极成像

基本信息

  • 批准号:
    6097424
  • 负责人:
  • 金额:
    $ 42.71万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-06-01 至 2004-05-31
  • 项目状态:
    已结题

项目摘要

We recently demonstrated heterogeneous myocardial sympathetic innervation in a colony of German shepherd dogs with ventricular arrhythmia and sudden cardiac death. The proposed research will apply scintigraphic methods to study the development of sympathetic nerves in these arrhythmic animals, and determine the effects of altered nerve development on adrenergic receptors, gap junctions, and repolarization responses. In Aim 1, we will study the postnatal development of myocardial innervation and perfusion and compare the results to the postnatal development of ventricular arrhythmias. The hypothesis to be tested is that postnatal maturation of sympathetic innervation is delayed in this colony of animals, and this delayed maturation is a primary determinant of ventricular arrhythmia. In Aim 2, we will study the effects of modulation of sympathetic nerve growth on the expression of ventricular arrhythmias. We will test the hypothesis that modulation of sympathetic nerve growth, or induced homogeneity of innervation will decrease the frequency and severity of arrhythmias. In Aim 3, we will study effects of regional denervation on the distribution of sympathetic nerve histology, myocyte gap junctions, and alpha and beta adrenergic receptor density and affinity. We will test the hypothsosis that heterogeneous spatial gradients of sympathic innervation result in associated gradients in adrenergic receptors and gap junctions. Aim 4 will study the developmental effects of sympathetic innervation on local myocardial repolarization. The hypothesis to be tested is that heterogeneous innervation results in local abnormalities of myocardial repolarization during the basal state and during sympathetic stimulation. The unique opportunity to investigate the development of cardiac sympathetic innervation and compare functional abnormalities of the sympathetic nerves to myocardial perfusion, signal transduction, intercellular communication and cardiacarrhythmia. These studies may provide a more comprehensive understanding of the interaction of the sympathetic nervous system and arrhythmogenesis.
我们最近证实了异质心肌交感神经

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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MICHAEL W DAE其他文献

MICHAEL W DAE的其他文献

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{{ truncateString('MICHAEL W DAE', 18)}}的其他基金

NERVE AND REPOLARIZATION IMAGING IN SUDDEN CARDIAC DEATH
心源性猝死的神经和复极成像
  • 批准号:
    6640846
  • 财政年份:
    2000
  • 资助金额:
    $ 42.71万
  • 项目类别:
NERVE AND REPOLARIZATION IMAGING IN SUDDEN CARDIAC DEATH
心源性猝死的神经和复极成像
  • 批准号:
    6537834
  • 财政年份:
    2000
  • 资助金额:
    $ 42.71万
  • 项目类别:
NERVE AND REPOLARIZATION IMAGING IN SUDDEN CARDIAC DEATH
心源性猝死的神经和复极成像
  • 批准号:
    6390750
  • 财政年份:
    2000
  • 资助金额:
    $ 42.71万
  • 项目类别:
NONINVASIVE ASSESSMENT OF CARDIAC ADRENERGIC INNERVATION
心脏肾上腺素神经支配的无创评估
  • 批准号:
    6109581
  • 财政年份:
    1998
  • 资助金额:
    $ 42.71万
  • 项目类别:
NONINVASIVE ASSESSMENT OF CARDIAC ADRENERGIC INNERVATION
心脏肾上腺素神经支配的无创评估
  • 批准号:
    6241702
  • 财政年份:
    1997
  • 资助金额:
    $ 42.71万
  • 项目类别:
RADIONUCLIDE IMAGING USING I 125 MIBG IN NEWBORN HEARTS
使用 I 125 MIBG 对新生儿心脏进行放射性核素成像
  • 批准号:
    2233781
  • 财政年份:
    1996
  • 资助金额:
    $ 42.71万
  • 项目类别:
RADIONUCLIDE IMAGING USING I 125 MIBG IN NEWBORN HEARTS
使用 I 125 MIBG 对新生儿心脏进行放射性核素成像
  • 批准号:
    2378866
  • 财政年份:
    1996
  • 资助金额:
    $ 42.71万
  • 项目类别:
RADIONUCLIDE IMAGING USING I 125 MIBG IN NEWBORN HEARTS
使用 I 125 MIBG 对新生儿心脏进行放射性核素成像
  • 批准号:
    2668752
  • 财政年份:
    1996
  • 资助金额:
    $ 42.71万
  • 项目类别:
NONINVASIVE ASSESSMENT OF CARDIAC ADRENERGIC INNERVATION
心脏肾上腺素神经支配的无创评估
  • 批准号:
    3470903
  • 财政年份:
    1988
  • 资助金额:
    $ 42.71万
  • 项目类别:
NONINVASIVE ASSESSMENT OF CARDIAC ADRENERGIC INNERVATION
心脏肾上腺素神经支配的无创评估
  • 批准号:
    3470901
  • 财政年份:
    1988
  • 资助金额:
    $ 42.71万
  • 项目类别:

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