Building the Queen's University of Belfast AMR Network (QUBAN)

建设贝尔法斯特女王大学 AMR 网络 (QUBAN)

• 批准号: EP/M027473/1
• 负责人: Steven Bell
• 金额: $ 50.38万
• 依托单位: Queen's University Belfast
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM027473%2F1
• 关键词: Building; Queen; University; Belfast; AMR

Antimicrobial resistance (AMR) is becoming a serious health issue since the number of bacteria which are resistant to existing antibiotics is rising faster than the supply of new antibiotics. This proposal aims to encourage researchers from Engineering and Physical Sciences in QUB to engage with the AMR problem by bringing them into contact with specialist AMR researchers who are primarily located in the Schools of Biology and Medicine, Dentistry & Biomedical Science (MDBS) and are much more familiar with the issues surrounding AMR. They can also provide a clinical perspective. This will form the basis for a new Queen's University Belfast Antimicrobial Network, QUBAN. The network will focus on the Research Councils' Theme: "Accelerating Therapeutic and Diagnostics Development". We have already identified 33 researchers from across six Schools/Centres in QUB who will be obvious members of QUBAN but we anticipate, and will actively promote, further engagement from other researchers within these Schools and from the wider research community in the University. There are exciting possibilities for using our expertise in advanced materials and processing to develop novel approaches to combating AMR through use of microbicides that are not based on small molecule drugs, these range from photogenerated electrons to cold plasmas. Similarly, modifying surfaces can help in preventing infection while sensors can be used to detect infection at the early stages. There is strength-in-depth in all these areas within QUB. QUBAN is designed to promote interdisciplinary working through a series of activities that will run throughout the 24 month duration of the programme and beyond. Important among these are the Sandpits which are planned in Months 3 and 14. The Month 3 event will be the first major forum where we will bring together interested parties from across the University to develop novel research ideas away from everyday distractions. Funding for Proof-of-Principle studies to take these projects to the level where they will be sufficiently advanced for external grant application funding will be available. This will be complemented by a parallel funding mechanism which will be an open call for smaller grants and will cover anything from buying out laboratory supervision to free up time for writing grant applications through to travel or small items of equipment. Researchers at all levels, including PDRAs and PhD students will be encouraged to become involved in QUBAN. There is a planned seminar programme but we also envisage funding short (three month) discipline-hopping visits to laboratories in other Schools/Faculties by PhD students and "Dragon's Den" competitions for PDRAs. The programme will be driven forward by the two PIs along with a Technical Management Group who will prioritise applications for funding the Proof-of-Principle proposals arising from Sandpit events and also help to set the scientific direction to the Seminar series, poster sessions and Sandpits. In addition, we will have a high level Steering Committee who will help to set the strategic direction of the Network. This Committee will be Chaired by Prof James McElnay, the University's PVC for Research and have 3 other senior academic members. Prof Rafael Canton (University Hospital Ramon y Cajal, Spain) a world leading expert on AMR, Prof Duncan Graham (Director of the Centre for Molecular Nanometrology, Strathclyde) a leading proponent of application of physical sciences to healthcare problems, and Prof Chris Hardacre (Head of School CCE, QUB) who has extensive experience in coordinating multicentre research grants. The Steering Committee will review progress every six months against targets, outputs/pathways to impact, publications and any IPR issues that may arise, ensuring the successful investment and delivery of the BTG award.

抗菌素耐药性(AMR)正成为一个严重的健康问题，因为对现有抗生素具有耐药性的细菌数量的增长速度快于新抗生素的供应。这项建议旨在鼓励昆士兰大学工程和物理科学的研究人员接触AMR问题，让他们接触主要位于生物学和医学院、牙科和生物医学科学(MDB)的专家AMR研究人员，他们对围绕AMR的问题更加熟悉。它们还可以提供临床视角。这将构成新的贝尔法斯特女王大学抗菌网络QUBAN的基础。该网络将重点关注研究理事会的主题：“加快治疗和诊断学的发展”。我们已经确定了来自昆士兰大学六所学校/中心的33名研究人员，他们显然将成为QUBAN的成员，但我们预计，并将积极促进这些学校和大学更广泛的研究社区的其他研究人员的进一步参与。利用我们在先进材料和加工方面的专业知识，通过使用不基于小分子药物的杀菌剂，从光生电子到冷等离子体，开发抗击AMR的新方法，这是令人兴奋的可能性。同样，修改表面可以帮助防止感染，而传感器可以用于在早期阶段检测感染。昆士兰大学在所有这些领域都有深入的实力。QUBAN旨在通过一系列活动促进跨学科工作，这些活动将贯穿整个方案的24个月及以后。其中最重要的是计划在第三个月和第十四个月举行的沙坑活动。第三个月的活动将是我们将来自整个大学的感兴趣的各方聚集在一起，从日常干扰中开发新的研究想法的第一个主要论坛。将为原则验证研究提供资金，以使这些项目达到足以为外部赠款申请提供资金的水平。这将得到一个平行的资助机制的补充，该机制将公开募集较少的赠款，涵盖从买断实验室监督到腾出时间撰写拨款申请到旅行或小型设备的一切内容。将鼓励包括PDRA和博士生在内的各级研究人员参与QUBAN。我们有一个计划中的研讨会计划，但我们也设想资助博士生到其他学校/学院的实验室进行短期(三个月)的跨学科访问，以及为PDRA举办的龙穴比赛。该方案将由两个私人投资促进机构和一个技术管理小组推动，技术管理小组将优先为沙坑活动产生的原则证明提案提供资金申请，并帮助确定研讨会系列、海报会议和沙坑的科学方向。此外，我们将有一个高级别的指导委员会，该委员会将帮助制定网络的战略方向。该委员会将由詹姆斯·麦克尔奈教授担任主席，他是该大学的PVC for Research，并有其他3名高级学术成员。拉斐尔·坎顿教授(西班牙拉蒙y Cajal大学医院)是AMR方面的世界领先专家，Duncan Graham教授(Strathclyde分子纳米计量学中心主任)是将物理科学应用于医疗保健问题的主要倡导者，Chris Harduck教授(昆士兰大学CCE学院院长)在协调多中心研究拨款方面拥有丰富经验。指导委员会将每六个月对照目标、产出/影响途径、出版物和可能出现的任何知识产权问题审查进展情况，以确保BTG奖的成功投资和交付。

项目成果

Atmospheric pressure non-thermal plasma exposure reduces Pseudomonas aeruginosa lipopolysaccharide toxicity in vitro and in vivo.

大气压非热等离子体暴露可降低铜绿假单胞菌脂多糖的体外和体内毒性。

• DOI: 10.1016/j.micpath.2019.103679
• 发表时间: 2019
• 期刊: Microbial pathogenesis
• 影响因子: 3.8
• 作者: Barakat MM

Optimization of singlet oxygen production from photosensitizer-incorporated, medically relevant hydrogels.

优化含有光敏剂的医学相关水凝胶的单线态氧生产。

• DOI: 10.1002/jbm.b.33562
• 发表时间: 2017-02
• 期刊: Journal of biomedical materials research. Part B, Applied biomaterials
• 作者: De Baróid ÁT;McCoy CP;Craig RA;Carson L;Andrews GP;Jones DS;Gorman SP
• 通讯作者: Gorman SP

Non-thermal Plasma Exposure Rapidly Attenuates Bacterial AHL-Dependent Quorum Sensing and Virulence.

• DOI: 10.1038/srep26320
• 发表时间: 2016-05-31
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Flynn PB;Busetti A;Wielogorska E;Chevallier OP;Elliott CT;Laverty G;Gorman SP;Graham WG;Gilmore BF
• 通讯作者: Gilmore BF

Surface-Enhanced Raman Spectroscopy for the Detection of a Metabolic Product in the Headspace Above Live Bacterial Cultures

表面增强拉曼光谱用于检测活细菌培养物上方顶空的代谢产物

• DOI: 10.1002/ange.201808185
• 发表时间: 2018
• 期刊: Angewandte Chemie
• 作者: Kelly J

Nanodelivery strategies for the treatment of multidrug-resistant bacterial infections.

• DOI: 10.1002/jin2.48
• 发表时间: 2018-09
• 期刊: Journal of interdisciplinary nanomedicine
• 作者: Jiang L;Lin J;Taggart CC;Bengoechea JA;Scott CJ
• 通讯作者: Scott CJ