Bioplastic polymers based on aromatic dicarboxylic acids derived from lignin

基于源自木质素的芳香族二羧酸的生物塑料聚合物

• 批准号: EP/M028550/1
• 负责人: Timothy Bugg
• 金额: $ 43.6万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM028550%2F1
• 关键词: Bioplastic; polymers; based; aromatic; dicarboxylic

Aromatic chemicals are crucial in bioplastics to convey functionality, including strength and flexibility. Currently, thesearomatic chemicals can only be sourced from fossil based inputs, limiting applications, increasing the cost andenvironmental impact. Lignin, the 2nd most abundant organic polymer in plants, is one of the few potential natural sourcesof aromatic chemicals. Building on a successful feasibility study that proved that the aromatic diacids inherent within lignincould be extracted and substituted in polyester based plastics, this project aims to demonstrate that these metabolites canbe produced in a commercially viable manner by the innovative use of modified bacteria to selectively control lignindisintegration when matched with novel chemical processes in scalable batch/continuous reactors. Larger trials will convertthe resultant kg quantities of diacids into novel block copolyesters, for evaluation in a high value global bioplastics marketof value >£150m.

芳香族化学物质对生物塑料的功能至关重要，包括强度和柔韧性。目前，这些人造化学物质只能来自化石原料，限制了应用，增加了成本和对环境的影响。木质素是植物中含量第二丰富的有机聚合物，是少数潜在的芳香化学物质的天然来源之一。在一项成功的可行性研究的基础上，该研究证明木质素中固有的芳香族二酸可以在聚酯基塑料中提取和取代，该项目旨在证明这些代谢物可以通过创新的使用改性细菌来选择性地控制木质素分解，并在可扩展的间歇/连续反应器中与新的化学工艺相匹配，以商业上可行的方式生产。更大的试验将把所得的公斤数量的二酸转化为新型的块状共聚酯，用于价值150亿英镑的高价值全球生物塑料市场的评估。

项目成果

Biocatalytic conversion of lignin to aromatic dicarboxylic acids in Rhodococcus jostii RHA1 by re-routing aromatic degradation pathways

• DOI: 10.1039/c5gc01347j
• 发表时间: 2015-01-01
• 期刊: GREEN CHEMISTRY
• 影响因子: 9.8
• 作者: Mycroft, Zoe;Gomis, Maria;Bugg, Timothy D. H.
• 通讯作者: Bugg, Timothy D. H.

Metabolic engineering of Rhodococcus jostii RHA1 for production of pyridine-dicarboxylic acids from lignin.

• DOI: 10.1186/s12934-020-01504-z
• 发表时间: 2021-01-19
• 期刊: Microbial cell factories
• 影响因子: 6.4
• 作者: Spence EM;Calvo-Bado L;Mines P;Bugg TDH
• 通讯作者: Bugg TDH

Microbial hosts for metabolic engineering of lignin bioconversion to renewable chemicals

• DOI: 10.1016/j.rser.2021.111674
• 发表时间: 2021-10-06
• 期刊: RENEWABLE & SUSTAINABLE ENERGY REVIEWS
• 影响因子: 15.9
• 作者: Bugg, Timothy D. H.;Williamson, James J.;Alberti, Fabrizio
• 通讯作者: Alberti, Fabrizio