权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Foresight Fellowship in Manufacturing: Analytical technologies in continuous and additive manufacturing

制造业远见奖学金：连续和增材制造中的分析技术

基本信息

批准号：
EP/N009126/1
负责人：
Jonathan Aylott
金额：
$ 16.87万
依托单位：
University of Nottingham
依托单位国家：
英国
项目类别：
Fellowship
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FN009126%2F1
关键词：
Foresight Fellowship Manufacturing Analytical technologies

项目摘要

This Fellowship application seeks to accelerate the uptake of continuous and additive manufacturing in the pharmaceutical industry. Continuous manufacturing is widely used in many sectors, where just-in-time protocols are common. Additive manufacturing, encompassing 3D-printing, has received much attention recently as printers have become commercially available. Additive manufacturing is a very flexible process and is currently used predominantly for prototype manufacture, enabling personalisation of products. However, scaling-up additive manufacturing processes is challenging and the vision of scales-out (multiple printers or print heads) is often suggested. In contrast, continuous manufacturing processes offer a more direct route to scale-up and are also flexible; the same production line can be used to manufacture a number of different products. However quality assurance protocols in continuous manufacturing are challenging.Many reasons are given for the pharmaceutical industry not adopting the latest manufacturing technologies, chief among these are regulatory concerns. This is in part due to innate conservatism from the regulators (though the FDA is encouraging change) but also due to a lack of analytical technologies being integrated with the continuous manufacturing production lines to ensure product quality. It is these analytical challenges that this Fellowship seeks to address.

该奖学金申请旨在加速制药行业对连续和增材制造的采用。连续制造广泛应用于许多行业，其中准时制协议是常见的。随着打印机的商用，包括3D打印在内的增材制造最近受到了广泛关注。增材制造是一个非常灵活的过程，目前主要用于原型制造，实现产品的个性化。然而，按比例放大增材制造工艺具有挑战性，并且经常建议横向扩展（多个打印机或打印头）的愿景。相比之下，连续生产工艺提供了一条更直接的扩大规模的途径，而且也很灵活;同一条生产线可以用于生产许多不同的产品。然而，连续生产的质量保证协议是具有挑战性的。制药行业不采用最新生产技术的原因有很多，其中最主要的是监管问题。这在一定程度上是由于监管机构固有的保守主义（尽管FDA鼓励改变），但也是由于缺乏与连续制造生产线集成以确保产品质量的分析技术。正是这些分析挑战，本奖学金寻求解决。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling.

DOI：
10.1038/s41467-020-19445-x
发表时间：
2020-11-17
期刊：
Nature communications
影响因子：
16.6
作者：
Kotowska AM;Trindade GF;Mendes PM;Williams PM;Aylott JW;Shard AG;Alexander MR;Scurr DJ
通讯作者：
Scurr DJ

Modelling protein therapeutic co-formulation and co-delivery with PLGA nanoparticles continuously manufactured by microfluidics