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Foresight Fellowship in Manufacturing: "High-throughput functionalization of biomaterials for personalized healthcare"

制造业远见奖学金：“用于个性化医疗保健的生物材料的高通量功能化”

基本信息

批准号：
EP/N009134/1
负责人：
Simon Webb
金额：
$ 15.82万
依托单位：
University of Manchester
依托单位国家：
英国
项目类别：
Fellowship
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FN009134%2F1
关键词：
Foresight Fellowship Manufacturing throughput functionalization

项目摘要

Both "Advanced and Functional Materials" and "Biotechnology" have been identified as pervasive technologies for future manufacturing activities in the UK. This Fellowship will join these two areas by developing chemical and biological technologies to create advanced functionalized biomaterials, taking advantage of the Fellow's cross-disciplinary expertise at the chemistry/biology interface. Working with manufacturers of biomaterials for healthcare and personal care, hybrid biomaterials will be produced that are able to heal and diagnose.An aging population needs cheaper biomedical materials with improved performance, but robust chemical and biotechnological processes for biomaterial functionalization are needed to create these materials. High-throughput modular methodologies are proposed for the modification of nanostructured biomaterials that will allow manufacturers to create tailored high-quality products for different markets, methodology that is able to respond quickly to the needs of customers (e.g. patients). These methodologies will draw on the UK's strengths in biotechnology to achieve a step change in cost reduction and an increase in performance; even a small reduction in costs to the NHS would bring significant benefits to the UK.The Fellowship will address this problem through work in three key theme areas: (1) developing simple, cheap and easy-to-access methodologies for adding reactive nanoparticles to biomaterials; (2) using synthetic biology and biotechnology to functionalise biomaterials; (3) using synthetic chemistry to produce value-added biomaterials. Each theme area has been identified as an exciting and highly interdisciplinary field that is ripe for exploitation, but where poor communication between experts in different fields is hampering progress. For example, there is insufficient involvement of industrial biotechnologists, synthetic chemists and supramolecular chemists in biomaterials manufacture despite clear synergies in expertise and the importance of this area to UK manufacturing.This Fellowship will build networks between biomaterials academics and biomaterials manufacturers, with partnerships backed up through meetings, researcher exchanges and follow-on funding. The Fellow will stimulate new innovative approaches to collaborative research by interacting with leading international researchers in Europe, the US and Australia/New Zealand who have complementary expertise to that of the applicant. The applicant will engage with leading UK manufacturers and international academic researchers, both through personal meetings and by helping to organise industry-academia meetings and developing new funded collaborations.At the end of this Fellowship, new easy-to-use chemical and biochemical methodologies will have been developed that will have applicability across academic and non-academic biomaterials research, producing new opportunities for UK manufacturing.

“先进和功能材料”和“生物技术”已被确定为英国未来制造活动的普遍技术。该奖学金将通过开发化学和生物技术来加入这两个领域，以创造先进的功能化生物材料，利用研究员在化学/生物学界面的跨学科专业知识。与医疗保健和个人护理用生物材料制造商合作，将生产出能够治愈和诊断的混合生物材料。人口老龄化需要更便宜、性能更好的生物医学材料，但需要强大的化学和生物技术工艺来实现生物材料的功能化。高通量模块化方法被提出用于纳米结构生物材料的改性，这将允许制造商为不同的市场创建量身定制的高质量产品，该方法能够快速响应客户（例如患者）的需求。这些方法将利用英国在生物技术方面的优势，实现成本降低和性能提高的阶跃变化;即使是NHS成本的小幅降低也会为英国带来重大利益。该奖学金将通过三个关键主题领域的工作来解决这个问题：（1）开发简单，廉价和易于获得的方法，将活性纳米颗粒添加到生物材料中;（2）利用合成生物学和生物技术使生物材料功能化;（3）利用合成化学生产增值生物材料。每个主题领域都被确定为一个令人兴奋的高度跨学科领域，开发时机已经成熟，但不同领域的专家之间缺乏沟通阻碍了进展。例如，尽管在专业知识和该领域对英国制造业的重要性方面存在明显的协同作用，但工业生物技术专家，合成化学家和超分子化学家在生物材料制造中的参与不足。该奖学金将在生物材料学者和生物材料制造商之间建立网络，通过会议，研究人员交流和后续资金支持伙伴关系。该研究员将通过与欧洲，美国和澳大利亚/新西兰的领先国际研究人员进行互动，激发新的创新方法进行合作研究，这些研究人员具有与申请人互补的专业知识。申请人将与英国领先的制造商和国际学术研究人员进行交流，包括通过个人会议和帮助组织行业-学术会议以及开发新的资助合作。在该奖学金结束时，将开发出新的易于使用的化学和生物化学方法，这些方法将适用于学术和非学术生物材料研究，为英国制造业创造新的机会。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

High-throughput chemical and chemoenzymatic approaches to saccharide-coated magnetic nanoparticles for MRI.

DOI：
10.1039/c9na00376b
发表时间：
2019-09-11
期刊：
NANOSCALE ADVANCES
影响因子：
4.7
作者：
Fallows, Thomas W.;McGrath, Andrew J.;Silva, Joana;McAdams, Simon G.;Marchesi, Andrea;Tuna, Floriana;Flitsch, Sabine L.;Tilley, Richard D.;Webb, Simon J.
通讯作者：
Webb, Simon J.

Magnetophoretic Behavior of 3T3 Cells Incubated with Saccharide-Coated MNPs