HYDROGEN FLOURIDE CHEMICAL LASER SYSTEM FOR CORNEAL

提出了研制脉冲氟化氢化学激光器的设想 专门设计用于角膜显微手术的系统。 激光参数，如脉冲能量、脉冲持续时间、光束质量和 输出光谱将被优化用于角膜显微手术。 与在医疗环境中使用相关的问题（如激光尺寸和 包装、燃料和废气处理、EMI抑制和光纤 激光辐射的传递）。 具体目标和 本研究的目的是：1）确定光学 性能和最佳消融参数， 去除角膜组织，2）确定空间和时间分辨率 和最佳组织切除的控制要求，3）评估 照射后组织学检查显示邻近组织损伤 组织，4）开发一个原型HF化学激光系统， 角膜显微手术的激光参数，以及5）考虑导管 通过光纤系统传送激光辐射。 的 第一阶段工作的方法将包括修改太阳神模型 PCLI脉冲HF化学激光器提供激光参数的变化， 微尺度激光/组织相互作用实验，以及 组织样品的辐照后表征。 如果成功，该计划将继续在第二阶段和第三阶段SBIR 致力于开发一种新的临床仪器， 显微手术使用安全有效的红外激光照射。

It is proposed to develop a pulsed hydrogen fluoride (HF) chemical laser system that is specifically designed for use in corneal microsurgery. Laser parameters such as pulse energy, pulse duration, beam quality, and output spectra will be optimized for application in corneal microsurgery. Issues related to use in a medical environment (such as laser size and packaging, fuels and exhaust handling, EMI suppression, and fiber optic delivery of laser radiation) will be addressed. The specific aims and objectives of the proposed research are: 1) to determine optical properties and optimal ablation parameters for efficient microsurgical removal of corneal tissue, 2) to determine spatial and temporal resolution and control requirements for optimal tissue removal, 3) to evaluate adjacent tissue damage by histological examination of post-irradiated tissues, 4) to develop a prototype HF chemical laser system with refined laser parameters for corneal microsurgery, and 5) to consider catheter delivery of laser radiation by means of an optical fiber system. The methodology of Phase I work will include modification of a Helios Model PCLI pulsed HF chemical laser to provide variation of laser parameters, microscale laser/tissue interactions experiments, and pre- and post-irradiation characterization of tissue samples. If successful, the program will be continued in Phase II and Phase III SBIR work to develop a new clinical instrument that permits refined corneal microsurgery using safe and effective infrared laser irradiation.