HYDROGEN FLUORIDE CHEMICAL LASER SYSTEM CORNEAL SURGERY

氟化氢化学激光系统 角膜手术

• 批准号: 3507639
• 负责人: WILLIAM Q JEFFERS
• 金额: $ 26.08万
• 依托单位: HELIOS, INC.
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-30 至 1990-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3507639
• 关键词: biomedical automation; biomedical equipment safety; clinical biomedical equipment; corneal endothelium; dissection; eye laser surgery; fiber optics; histology; human tissue; infrared radiation; laboratory rabbit; lasers; nonhuman therapy evaluation; radial keratotomy; refractive keratoplasty; surgery material /equipment; wound healing

It is proposed to develop a repetitively pulsed (rp) hydrogen fluoride (HF) chemical laser system that is specifically designed for use in corneal microsurgery. Laser parameters such as output wavelength(s), beam quality and irradiance distribution, pulse energy, pulse duration, and pulse repetition frequency will be optimized for application in laser refractive keratectomy (LRK) and other corneal microsurgical procedures. Issues related to use in a clinical environment (such as laser size and packaging fuels and exhaust handling, EMI suppression, and beam delivery of laser radiation) will be addressed. In vitro and in vivo irradiation experiments together with post-irradiation ocular and histological examinations will be performed to optimize corneal LRK procedures, to measure the quality of tissue removal, to evaluate corneal wound healing, and to determine the quality and long-term stability of corneal optical changes induced by laser ablation. The specific aims and objectives of the proposed research are: 1) to demonstrate the formation of precise incisions and large are (up to 30 mm2) ablations of corneal surfaces using controlled and well- characterized HF chemical laser beams, 2) to measure the quality of tissue removal and the extent of adjacent tissue damage ( and inflammatory responses) at the surgical margin of resection with emphasis on the surface quality of the post-irradiated anterior stromal surface and its dependence on laser ablation parameters, 3) to determine initial and long-term corneal optical changes induced by laser ablation as a function of laser parameters, 4) to evaluate the rate and quality of epithelial and stromal wound healing as a function of laser parameters, and 5) to develop a prototype HF chemical laser system that is well suited to clinical use and well optimized for corneal ablation procedures. If Phase II research is successful, as judged by primate studies, Phase III development will commence with funding provided by Helios, HARC, HBI, and private investors. The ultimate goal of the proposed program is the development of a new clinical instrument that permits refined corneal microsurgery using safe and effective infrared chemical laser irradiation.

建议开发一种重复脉冲(RP)氢气 专门设计的氟化物(HF)化学激光系统 用于角膜显微手术。激光参数，如输出 波长(S)、光束质量和辐照度分布、脉冲 能量、脉冲持续时间和脉冲重复频率 激光屈光性角膜切削术(LRK)的应用优化 以及其他角膜显微外科手术。与使用有关的问题 在临床环境中(例如激光尺寸和包装燃料 以及排气处理、EMI抑制和激光光束传输 辐射)将得到解决。体外和体内照射 照射后眼部和组织学联合实验 将进行检查以优化角膜LRK手术， 测量组织切除的质量，评估角膜创伤 治疗，并确定质量和长期稳定性 激光消融引起的角膜光学改变。具体的 拟议研究的目的和目标是：1)论证 形成精确的切割和大弧度(最大可达30平方毫米) 使用可控的和良好的- 表征高频化学激光光束，2)测量质量 组织切除和邻近组织损伤的程度(和 炎性反应)在手术切缘 重视前牙照射后的表面质量 基质表面及其对激光消融参数的依赖关系， 3)确定初始和长期的角膜光学变化 激光烧蚀诱导作为激光参数的函数，4) 评估上皮和间质创面的速度和质量 作为激光参数的函数进行愈合，以及5)开发一种 一种适合临床的高频化学激光系统样机 使用并优化了角膜切削术。 如果第二阶段研究成功，就像灵长类研究判断的那样， 第三阶段的开发将由以下机构提供资金 Helios、HARC、HBI和私人投资者。的最终目标是 拟议的计划是开发一种新的临床 允许使用SAFE进行精细角膜显微手术的仪器 和有效的红外化学激光照射。