LASER WELDING OF OCULAR TISSUES

这一应用的目的是发展激光组织 焊接作为均匀伤口愈合的辅助手段，减少残留物 角膜移植中的散光。角膜焊接可能会进一步 协助固定角膜上镜下晶状体和其他角膜 手术包括修复角膜伤口。 这项建议的具体目的是确定适当的 角膜激光焊接的红外波长(S)和功率要求 外科，基于波化学激光提供的理想范围 吸收深度为0.15 mm至0.5 mm穿透的波长 水。在角膜焊接中使用它们将提供必要的信息 设计一种具有满足以下要求的特性的固体激光器 临床应用。 猪和人眼库均一线状创面的实验研究 在体外的眼睛，以及有限数量的兔眼在体内，将允许 最大限度地发展全厚度角膜焊接技术 强度和一致性。组织学结果和加压 研究将用来确定结果的一致性。这个 常规实现人体角膜鲍曼层焊接的能力 将会被确定。

The objective of this application is the development of laser tissue welding as an adjunct to homogeneous wound healing, and reduce residual astigmatism in corneal transplantation. Corneal welding may further assist in securing epikeratophakia lenticules and other corneal procedures including repair of corneal wounds. The specific aim of this proposal is the determination of the appropriate infrared wavelength(s) and power requirements for corneal laser welding surgery, based on the wave chemical lasers provide in ideal range of wavelengths with absorption depths of 0.15 to 0.5 mm penetration in water. Their use in corneal welding will provide information necessary to the design of a solid-state laser of the required characteristics for clinical use. Experimentation of uniform linear wounds in porcine and human eyebank eyes in vitro, and limited number of rabbit eyes in vivo, will allow the development of techniques for full thickness corneal welding to maximum strength and uniformity. Histological results as well as pressurization studies will be used to determine the consistency of results. The ability to routinely achieve welding of Bowman's layer in human corneas will be determined.