LASER WELDING OF OCULAR TISSUES

眼组织激光焊接

• 批准号: 3497058
• 负责人: WILLIAM Q JEFFERS
• 金额: $ 5万
• 依托单位: HELIOS, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3497058
• 关键词: animal tissue; bioengineering /biomedical engineering; clinical biomedical equipment; cornea; corneal stroma; electron microscopy; eye laser surgery; histology; human subject; infrared radiation; keratoplasty; laboratory rabbit; lasers; method development; optics; wound healing

The objective of this application is the development of laser tissue welding as an adjunct to homogeneous wound healing, and reduce residual astigmatism in corneal transplantation. Corneal welding may further assist in securing epikeratophakia lenticules and other corneal procedures including repair of corneal wounds. The specific aim of this proposal is the determination of the appropriate infrared wavelength(s) and power requirements for corneal laser welding surgery, based on the wave chemical lasers provide in ideal range of wavelengths with absorption depths of 0.15 to 0.5 mm penetration in water. Their use in corneal welding will provide information necessary to the design of a solid-state laser of the required characteristics for clinical use. Experimentation of uniform linear wounds in porcine and human eyebank eyes in vitro, and limited number of rabbit eyes in vivo, will allow the development of techniques for full thickness corneal welding to maximum strength and uniformity. Histological results as well as pressurization studies will be used to determine the consistency of results. The ability to routinely achieve welding of Bowman's layer in human corneas will be determined.

该应用的目的是开发激光组织 焊接作为均匀伤口愈合的辅助手段，并减少残留 角膜移植中的散光。 角膜焊接可进一步 协助固定表层角膜晶状体微透镜和其他角膜 手术包括修复角膜伤口。 本提案的具体目标是确定适当的 角膜激光焊接的红外波长和功率要求 基于波化学激光器的手术提供了理想的范围 吸收深度为 0.15 至 0.5 mm 的波长，穿透力 水。 它们在角膜焊接中的使用将提供必要的信息 设计具有所需特性的固体激光器 临床使用。 猪和人眼库均匀线状伤口的实验 体外的眼睛，以及体内有限数量的兔子眼睛，将允许 最大限度地发展全层角膜焊接技术 强度和均匀度。 组织学结果以及加压 研究将用于确定结果的一致性。 这 能够常规地实现人类角膜鲍曼层的焊接 将被确定。