LASER TREPHINATION OF THE CORNEA

角膜激光钻孔术

• 批准号: 3496975
• 负责人: WILLIAM Q JEFFERS
• 金额: $ 5万
• 依托单位: HELIOS, INC.
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-30 至 1989-03-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3496975
• 关键词: biomedical equipment safety; cats; clinical biomedical equipment; cornea; electron microscopy; eye laser surgery; eye transplantation; keratoplasty; lasers; microscopy; photomicrography; surgery material /equipment; surgical wound; wound healing

It is proposed to develop a laser to perform non-contact trephination of the cornea. This laser could greatly improve the outcome of more than 30,000 corneal transplantations performed yearly in the United States. During Phase I, the aims of the research are to modify an existing laboratory HF laser for corneal trephination, to demonstrate reproducible, high quality circular corneal button, to compare healing rate, strength, and quality of laser-cut and mechanically cut cornea in animal models, and to conceptually design a prototype laser suitable for clinical use. The Phase II continuation of Phase I would include engineering design, construction, and test of the prototype laser; use in further animal studies; use to cut donor corneas for human corneal transplantations. The goal upon completion of Phase II is to have a laser ready for clinical trials in human transplantations trephining both donor(cadaver or eye bank eye) and recipient (Patient) tissue.

建议开发一种激光器来进行非接触式 角膜环钻术。 该激光器可以极大地改善 超过30,000例角膜移植手术的结果 每年在美国。 第一阶段的目标是 研究目的是修改现有的实验室高频角膜激光器 环钻，展示可重复的、高质量的圆形 角膜纽扣，比较愈合率、强度和质量 在动物模型中进行激光切割和机械切割角膜，并 概念性地设计适合临床使用的原型激光器。 第一阶段的第二阶段延续将包括工程 原型激光器的设计、建造和测试；使用于 进一步的动物研究；用于切割人类角膜的供体角膜 移植。 第二阶段完成后的目标是 准备用于人体移植临床试验的激光器 对供体（尸体或眼库眼睛）和受体进行环钻 （患者）组织。