Grand Challenge Network+ in Proton Therapy

质子治疗大挑战网络

• 批准号: EP/N027167/1
• 负责人: Karen Kirkby
• 金额: $ 86.27万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FN027167%2F1
• 关键词: Grand; Challenge; Network+; Proton; Therapy

In the UK one in two people are diagnosed with cancer during their lifetimes and of those who survive 41% can attribute their cure to a treatment including radiotherapy. Proton beam therapy (PBT) is a radical new type of radiotherapy, capable of delivering a targeted tumour dose with minimal damage to the surrounding healthy tissue. The NHS is investing £250m in two new "state of the art" PBT centres in London and Manchester. In addition, Oxford has attracted £110m (from HEFCE and business partners) for its new Centre for Precision Cancer Medicine, incorporating PBT. This EPSRC Network+ proposal seeks to bring the EPS community together with clinical, consumer and industrial partners and develop a national research infrastructure and roadmap in proton therapy. It capitalises on ~£300m of government investment and affords an opportunity for those not directly involved in the new proton centres to be actively involved in the national research effort in this area. This project has the backing of NCRI Clinical and Translational Radiotherapy Working Group and NHS England and will work with the national Proton Physics Research and Implementation Group of the National Physical Laboratory. It also involves industrial stakeholders, consumer groups and international partners (including PBT centres in Europe and USA and CERN). While PBT offers patients many advantages it also presents a wealth of technical challenges and opportunities where there is an unmet research and training need. This is where there the involvement of the EPS community is vital since this challenge in Healthcare Technologies requires expertise from across the EPS spectrum and maps on to themes in ICT, Digital Economy, Engineering, Mathematics, Manufacturing the Future, and the Physical Sciences and also finds synergies within quantum technologies. It directly maps onto the cross cutting capabilities identified in the Healthcare Technologies Grand Challenges. This is a highly multi-disciplinary area at the frontiers of physical intervention, which achieves high precision treatment with minimal invasiveness. This Network+ is particularly timely; it will afford the UK the opportunity to develop a world-leading research capability to inform the national agenda, capitalising on existing research excellence and the synergies that can be developed by bringing the clinical and EPS areas together. It will also collaborate with existing doctoral training provision to train the next generation of leaders where a national need has been identified. This proposed Network+ will create a national infrastructure to meet a national research and training need and will allow the UK community to work together in the multi-disciplinary field of proton research. This proposed Network+ will create a sustainable national proton beam infrastructure by drawing together sites where proton beams are already available (albeit at lower energies) and providing a route for the research community to access these facilities. As the new proton centres come on line they will add to this national resource and the centres will work together to provide a virtual national infrastructure for the UK, which by the end of the Network+ will be fully sustainable. The Network+ will also provide a route for those interested in the field but not requiring proton experiments to become involved. In addition, the Network+ will offer secondments ("Discipline Hops") into the clinical environment in both the UK and in PBT centres overseas. Working with NHS England the Network+ will develop a PBT training scheme. This will link the existing NHS provision with EPSRC Centres for Doctoral Training and allow equivalencies to be established and so provide a "fast track" to a skilled workforce and the next generation of leaders. The Network+ will also seek to engage with industry through joint research and secondments and with consumer groups, policy makers and the general public.

在英国，每两个人中就有一个人在其一生中被诊断出患有癌症，而在那些幸存下来的人中，41%的人可以将他们的治愈归功于包括放疗在内的治疗。质子束治疗（PBT）是一种激进的新型放射疗法，能够在对周围健康组织损伤最小的情况下提供靶向肿瘤剂量。英国国民医疗服务体系将投资2. 5亿英镑，在伦敦和曼彻斯特新建两个“最先进”的PBT中心。此外，牛津大学还为其新的精准癌症医学中心吸引了1.1亿英镑（来自HEFCE和商业合作伙伴），该中心将PBT纳入其中。该EPSRC Network+提案旨在将EPS社区与临床，消费者和工业合作伙伴聚集在一起，并开发质子治疗的国家研究基础设施和路线图。它利用了约3亿英镑的政府投资，并为那些没有直接参与新质子中心的人提供了积极参与该领域国家研究工作的机会。该项目得到了NCRI临床和转化放射治疗工作组和NHS英格兰的支持，并将与国家物理实验室的国家质子物理研究和实施小组合作。它还涉及工业利益攸关方、消费者团体和国际合作伙伴（包括欧洲和美国的PBT中心以及欧洲核研究组织）。虽然PBT为患者提供了许多优势，但在研究和培训需求未得到满足的情况下，它也带来了大量的技术挑战和机遇。这就是EPS社区参与的关键所在，因为医疗技术的这一挑战需要来自EPS频谱的专业知识，并映射到ICT，数字经济，工程，数学，制造未来和物理科学的主题，并在量子技术中找到协同作用。它直接映射到医疗保健技术大挑战中确定的跨领域能力。这是物理干预前沿的一个高度多学科的领域，它以最小的侵入性实现高精度治疗。这个网络+是特别及时的;它将为英国提供机会，发展世界领先的研究能力，为国家议程提供信息，利用现有的研究卓越和协同作用，可以通过将临床和EPS领域结合在一起来发展。它还将与现有的博士培训机构合作，在确定国家需求的情况下培训下一代领导人。这个拟议的网络+将创建一个国家基础设施，以满足国家研究和培训需求，并将允许英国社区在质子研究的多学科领域共同努力。拟议的Network+将通过汇集已经可用质子束（尽管能量较低）的地点并为研究界提供访问这些设施的路线，创建一个可持续的国家质子束基础设施。随着新的质子中心上线，它们将增加这一国家资源，这些中心将共同努力，为英国提供一个虚拟的国家基础设施，到Network+结束时，这一基础设施将完全可持续。Network+还将为那些对该领域感兴趣但不需要质子实验的人提供一条路线。此外，Network+将提供借调（“学科跳”）到英国和海外PBT中心的临床环境中。Network+将与英国国民保健服务（NHS）合作，制定一项PBT培训计划。这将把现有的NHS规定与EPSRC博士培训中心联系起来，并允许建立同等学历，从而为熟练劳动力和下一代领导人提供“快速通道”。Network+还将寻求通过联合研究和借调与工业界接触，并与消费者团体、决策者和公众接触。

项目成果

Monte Carlo simulation of a TEPC for microdosimetry of carbon ions

用于碳离子微剂量测定的 TEPC 的蒙特卡罗模拟

• DOI: 10.1016/j.radphyschem.2017.02.028
• 发表时间: 2017
• 期刊: Radiation Physics and Chemistry
• 影响因子: 2.9
• 作者: Galer S

Coupling Monte Carlo simulations with thermal analysis for correcting microdosimetric spectra from a novel micro-calorimeter

将蒙特卡罗模拟与热分析相结合，用于校正新型微量热计的微剂量光谱

• DOI: 10.1016/j.radphyschem.2017.02.055
• 发表时间: 2017
• 期刊: Radiation Physics and Chemistry
• 影响因子: 2.9
• 作者: Fathi K

Multi-institutional dosimetric delivery assessment of intracranial stereotactic radiosurgery on different treatment platforms

• DOI: 10.1016/j.radonc.2020.05.024
• 发表时间: 2020-06-01
• 期刊: RADIOTHERAPY AND ONCOLOGY
• 影响因子: 5.7
• 作者: Dimitriadis, Alexis;Tsang, Yatman;Clark, Catharine H.
• 通讯作者: Clark, Catharine H.

Automated microbeam observation environment for biological analysis-Custom portable environmental control applied to a vertical microbeam system.

• DOI: 10.1016/j.snb.2016.08.076
• 发表时间: 2017-03
• 期刊: Sensors and actuators. B, Chemical
• 作者: England MJ;Bigelow AW;Merchant MJ;Velliou E;Welch D;Brenner DJ;Kirkby KJ
• 通讯作者: Kirkby KJ