Global Challenge Network+ in Advanced Radiotherapy

先进放射治疗全球挑战网络

• 批准号: ST/N002423/1
• 负责人: Karen Kirkby
• 金额: $ 129.33万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FN002423%2F1
• 关键词: Global; Challenge; Network+; Advanced; Radiotherapy

In the UK one in two people are diagnosed with cancer during their lifetimes and of those who survive 40% can attribute their cure to treatment including radiotherapy. After surgery, radiotherapy is the most effective cure for cancer in the UK. The basic tenet of radiotherapy is to maximise the damage to the tumour (to sterilise it) while minimising the damage to the surrounding healthy tissue (to reduce side effects). In recent years radiotherapy has developed rapidly with the development of new machines and methodologies. These in turn, have resulted in better imaging, treatment planning and dosimetry, which enable the dose to be more accurately delivered and conformed to the tumour. They have also thrown up a range of interesting new challenges and issues all of which require innovation and solutions. This is exactly where the STFC community could make an enormous impact as they have exactly the skill set which is needed to effectively tackle the new challenges as they arise. This also brings in the expertise from CERN, which could prove invaluable for overcoming some of the imaging challenges in radiotherapy. In addition, the latest developments in radiotherapy - such as MR-linacs and proton therapy - evidence the need for the community to work together with commercial partners. If the UK is to remain competitive and deliver even better treatments for patients, and produce income and impact for the UK economy, it can no longer rely on serendipitous partnerships. This is what this Global Challenge Network+ in Advanced Radiotherapy seeks to address. This Network is aimed at creating a paradigm shift in the way in which radiotherapy research is undertaken and will create a pipeline, which directly translates into patient benefit and quality of life. It will catalyse new multidisciplinary partnerships between the clinical and STFC communities and provide radical and innovative solutions, which draw on the strengths and knowledge of the individual disciplines and weave them together to transcend traditional discipline boundaries, with the sum being greater than the constituent parts. This is a particularly exciting time to launch this network, with the NHS investment of £250m into two new centres for proton therapy at the Christie Hospital in Manchester and University College London Hospital in London and the recent funding by HEFCE of the Institute for Precision Cancer Medicine in Oxford. These clinical developments should act as a launch pad for multidisciplinary research collaborations in radiotherapy and develop strong links between the clinical and academic communities in STFC laboratories and universities. This Network will bring together cancer clinicians, clinical scientists and researchers from the biosciences with researchers from the STFC community in areas as diverse as particle and astrophysics, nuclear science, accelerator science, imaging, computational science and detectors to develop a research pipeline and contribute to a coordinated national plan and roadmap for advanced radiotherapy research across the UK. This is particularly timely and will strengthen the links between clinical radiotherapy and STFC scientists in both national laboratories and universities and is aligned with STFC Futures Programme, in particular the Healthcare Theme.This Global Challenge Network+ in Advanced Radiotherapy aims to work in partnership with the National Cancer Research Institute CTRad (Clinical and Translational Radiotherapy Research Working Group) engage the wider STFC funded capability (to encompass nuclear physics, particle physics and astronomy) in both the STFC national laboratories (ALICE, DIAMOND, ISIS, VELA/CLARA) and universities and to draw on the STFC experience and expertise within them. In doing so it aims to engage across the remit of STFC activities and aid their translation into the clinical environment.

在英国，每两个人中就有一个人在一生中被诊断出患有癌症，而那些存活下来的人中，40%可以将他们的治愈归功于包括放疗在内的治疗。手术后，放射治疗是英国最有效的癌症治疗方法。放射治疗的基本原则是最大限度地损害肿瘤（灭菌），同时最大限度地减少对周围健康组织的损害（减少副作用）。近年来，随着新设备和新方法的发展，放射治疗得到了迅速发展。这些反过来又导致了更好的成像，治疗计划和剂量测定，这使得剂量能够更准确地输送并符合肿瘤。他们还提出了一系列有趣的新挑战和问题，所有这些都需要创新和解决方案。这正是STFC社区可以产生巨大影响的地方，因为他们拥有有效应对新挑战所需的技能。这也带来了来自CERN的专业知识，这对于克服放射治疗中的一些成像挑战是非常宝贵的。此外，放射治疗的最新发展-如MR直线加速器和质子治疗-证明了社区与商业伙伴合作的必要性。如果英国要保持竞争力，为患者提供更好的治疗，为英国经济创造收入和影响，就不能再依赖偶然的合作伙伴关系。这就是这个全球挑战网络+在先进的放射治疗寻求解决。该网络的目的是在进行放射治疗研究的方式上创造一个范式转变，并将建立一个管道，直接转化为患者的利益和生活质量。它将促进临床和STFC社区之间的新的多学科合作伙伴关系，并提供激进和创新的解决方案，这些解决方案利用各个学科的优势和知识，并将它们编织在一起，超越传统的学科界限，其总和大于组成部分。这是一个特别令人兴奋的时间来启动这个网络，与英国国民保健服务投资2.5亿英镑到两个新的质子治疗中心在克里斯蒂医院在曼彻斯特和伦敦大学学院医院在伦敦和最近的资金由HEFCE的研究所精准癌症医学在牛津。这些临床发展应作为放射治疗多学科研究合作的发射台，并在STFC实验室和大学的临床和学术界之间建立强有力的联系。该网络将汇集来自生物科学的癌症临床医生，临床科学家和研究人员，以及来自STFC社区的研究人员，这些研究人员来自粒子和天体物理学，核科学，加速器科学，成像，计算科学和探测器等领域，以开发研究管道，并为协调的国家计划和路线图做出贡献。这是特别及时的，将加强国家实验室和大学的临床放射治疗和STFC科学家之间的联系，并与STFC未来计划保持一致，特别是医疗保健主题。这个先进放射治疗的全球挑战网络+旨在与国家癌症研究所CTRad合作（临床和转化放射治疗研究工作组）参与更广泛的STFC资助的能力（包括核物理、粒子物理和天文学）（ALICE、DIAMOND、ISIS、VELA/CANADA）和大学，并利用它们内部的STFC经验和专门知识。在这样做的过程中，它的目的是参与整个STFC活动的职权范围，并帮助他们转化为临床环境。

项目成果

Monte Carlo simulation of a TEPC for microdosimetry of carbon ions

用于碳离子微剂量测定的 TEPC 的蒙特卡罗模拟

• DOI: 10.1016/j.radphyschem.2017.02.028
• 发表时间: 2017
• 期刊: Radiation Physics and Chemistry
• 影响因子: 2.9
• 作者: Galer S

Coupling Monte Carlo simulations with thermal analysis for correcting microdosimetric spectra from a novel micro-calorimeter

将蒙特卡罗模拟与热分析相结合，用于校正新型微量热计的微剂量光谱

• DOI: 10.1016/j.radphyschem.2017.02.055
• 发表时间: 2017
• 期刊: Radiation Physics and Chemistry
• 影响因子: 2.9
• 作者: Fathi K

Multi-institutional dosimetric delivery assessment of intracranial stereotactic radiosurgery on different treatment platforms

• DOI: 10.1016/j.radonc.2020.05.024
• 发表时间: 2020-06-01
• 期刊: RADIOTHERAPY AND ONCOLOGY
• 影响因子: 5.7
• 作者: Dimitriadis, Alexis;Tsang, Yatman;Clark, Catharine H.
• 通讯作者: Clark, Catharine H.

Automated microbeam observation environment for biological analysis-Custom portable environmental control applied to a vertical microbeam system.

• DOI: 10.1016/j.snb.2016.08.076
• 发表时间: 2017-03
• 期刊: Sensors and actuators. B, Chemical
• 作者: England MJ;Bigelow AW;Merchant MJ;Velliou E;Welch D;Brenner DJ;Kirkby KJ
• 通讯作者: Kirkby KJ