TISSUE TEMPERATURE BY NEAR-INFRARED SPECTROSCOPY

这项研究的长期目标是开发光学仪器， 用于测量和成像组织温度的方法。在第一阶段， 将开发计算温度读数的技术， 水的近红外吸收带。这种干扰的影响 将确定来自其它组织成分的测量值。在 在第一阶段进行的初步研究中，将执行以下任务 承诺： - 确定水NIR吸收的波长，与 组织温度; - 选择具有良好组织穿透性的波长; - 确定光学带通对方法灵敏度的影响 以获得仪器设计的最佳标准; - 用近红外光谱仪检查组织成分的影响，以确定 其干扰程度，如果 以及对温度预测进行适当校正的方法 方程; - 在含有以下混合物的样本集上测试预测方程： 干扰物质和简单组织 模型; - 审查采用光学方法进行深度分辨的可行性 测量. 在该项目的第11阶段，将根据 第一阶段开发的方法。这些仪器将被测试，然后 用于测量临床领域的组织温度测量 兴趣

The long term goal of this research is to develop optical instruments and methods for measuring and imaging tissue temperature. In Phase 1, techniques will be developed that compute temperature readings from near-infrared absorption bands of water. The effect of interference on such measurements from other tissue components will be determined. In the initial studies to be performed during Phase I, the following tasks will be undertaken: -Determine wavelengths of water NIR absorption with high correlation to tissue temperature; -Select wavelengths that have good tissue penetration; -Determine the effect of optical bandpass on the sensitivity of the method in order to obtain optimal criteria for instrument design; -Examine effects of tissue components with NIR absorbances to determine their extent of interference, if any, and means for appropriate correction to the temperature prediction equation; -Test predicting equations on sample sets containing mixtures of interfering substances and simple tissue models; -Examine feasibility of adapting optical methods to depth-resolved measurements. In Phase 11 of this project, instruments will be constructed based on the methods developed in Phase I. These instruments will be tested and then used to measure tissue temperature measurements in areas of clinical interest.