TISSUE TEMPERATURE BY NEAR-INFRARED SPECTROSCOPY

这项研究的长期目标是开发光学仪器和 测量和成像组织温度的方法。在第一阶段， 将开发出计算温度读数的技术 水的近红外吸收带。干扰对这种情况的影响 其他组织成分的测量值将被确定。在 在第一阶段将进行的初步研究，将完成以下任务 已承担： -测定水的近红外吸收波长，与 组织温度； -选择具有良好组织穿透性的波长； -确定光学带通对方法灵敏度的影响 以获得仪器设计的最佳标准； -用近红外吸光度检查组织成分的影响，以确定 他们的干扰程度，如果 以及对温度预报进行适当修正的手段 方程； -在包含以下混合物的样本集上测试预测方程 干扰物质和简单组织 模型； -研究使光学方法适用于深度分辨的可行性 测量。 在该项目的第11阶段，仪器将基于 在第一阶段开发的方法这些仪器将进行测试，然后 用于测量临床区域的组织温度测量 利息。

The long term goal of this research is to develop optical instruments and methods for measuring and imaging tissue temperature. In Phase 1, techniques will be developed that compute temperature readings from near-infrared absorption bands of water. The effect of interference on such measurements from other tissue components will be determined. In the initial studies to be performed during Phase I, the following tasks will be undertaken: -Determine wavelengths of water NIR absorption with high correlation to tissue temperature; -Select wavelengths that have good tissue penetration; -Determine the effect of optical bandpass on the sensitivity of the method in order to obtain optimal criteria for instrument design; -Examine effects of tissue components with NIR absorbances to determine their extent of interference, if any, and means for appropriate correction to the temperature prediction equation; -Test predicting equations on sample sets containing mixtures of interfering substances and simple tissue models; -Examine feasibility of adapting optical methods to depth-resolved measurements. In Phase 11 of this project, instruments will be constructed based on the methods developed in Phase I. These instruments will be tested and then used to measure tissue temperature measurements in areas of clinical interest.