FLUORESCENCE IMAGING OF REGIONAL FLOW IN HEART

心脏区域血流的荧光成像

基本信息

  • 批准号:
    2423728
  • 负责人:
  • 金额:
    $ 10万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1997
  • 资助国家:
    美国
  • 起止时间:
    1997-09-30 至 1998-03-31
  • 项目状态:
    已结题

项目摘要

This research will develop instrumentation for a fully-automated approach to the evaluation of microregional circulation. This research is based on the working hypothesis that cell permeant fluorescent dyes or "molecular microspheres" can be spatially located by sequential fluorescence imaging of frozen tissue blocks during organ serial sectioning.. The project will develop procedures and adapt instrumentation to evaluate regional flow in an entire organ. During Phase I, feasibility of the technical methodology will be demonstrated through examination of dye optical and extraction properties as well as dye washout and distribution. The validity of the molecular microsphere method will be demonstrated by comparing dye distributions with distributions of 15 microM diameter microspheres simultaneously injected into coronary circulation. Phase I studies will demonstrate feasibility of the working hypothesis and provide design parameters for methods to work with larger hearts and for working with multiple dyes simultaneously. This project will provide researchers with the instrumentation to rapidly and automatically evaluate microregional flow in tissue using procedures similar to the standard procedures involved in radioactive and fluorescent microsphere flow determinations. PROPOSED COMMERCIAL APPLICATIONS Instrumentation and methods to rapidly and automatically evaluate molecular microsphere distributions in tissue will find applications in laboratories engaged in physiology and circulation research. The development of molecular microsphere methodology in the proposal will significantly enhance the commercial market for the Barlow Scientific microsphere imaging system in such laboratories.
本研究将开发全自动化的仪器

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Jeffrey J Kelly其他文献

Jeffrey J Kelly的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Jeffrey J Kelly', 18)}}的其他基金

Intelligent Microtome Instrumentation
智能切片机仪器
  • 批准号:
    7782776
  • 财政年份:
    2009
  • 资助金额:
    $ 10万
  • 项目类别:
Intelligent Microtome Instrumentation
智能切片机仪器
  • 批准号:
    7154878
  • 财政年份:
    2006
  • 资助金额:
    $ 10万
  • 项目类别:
Antibody Imaging for Regional Flow Measurements
用于区域流量测量的抗体成像
  • 批准号:
    6483721
  • 财政年份:
    2002
  • 资助金额:
    $ 10万
  • 项目类别:
Antibody Imaging for Regional Flow Measurements
用于区域流量测量的抗体成像
  • 批准号:
    6947739
  • 财政年份:
    2002
  • 资助金额:
    $ 10万
  • 项目类别:
Antibody Imaging for Regional Flow Measurements
用于区域流量测量的抗体成像
  • 批准号:
    6833822
  • 财政年份:
    2002
  • 资助金额:
    $ 10万
  • 项目类别:
SIMPLIFIED MEASUREMENT OF REGIONAL FLOW
区域流量的简化测量
  • 批准号:
    6537694
  • 财政年份:
    1999
  • 资助金额:
    $ 10万
  • 项目类别:
SIMPLIFIED MEASUREMENT OF REGIONAL FLOW
区域流量的简化测量
  • 批准号:
    6338293
  • 财政年份:
    1999
  • 资助金额:
    $ 10万
  • 项目类别:
SIMPLIFIED MEASUREMENT OF REGIONAL FLOW
区域流量的简化测量
  • 批准号:
    6017730
  • 财政年份:
    1999
  • 资助金额:
    $ 10万
  • 项目类别:
FLUORESCENCE IMAGING OF REGIONAL FLOW IN HEART
心脏区域血流的荧光成像
  • 批准号:
    2867633
  • 财政年份:
    1997
  • 资助金额:
    $ 10万
  • 项目类别:
FLUORESCENCE IMAGING OF REGIONAL FLOW IN HEART
心脏区域血流的荧光成像
  • 批准号:
    6183450
  • 财政年份:
    1997
  • 资助金额:
    $ 10万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了