Personalised Pulsatile Materials (PPM)

个性化脉动材料 (PPM)

• 批准号: EP/N033655/1
• 负责人: Katarina Novakovic
• 金额: $ 47.51万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FN033655%2F1
• 关键词: Personalised; Pulsatile; Materials; PPM

The project aims to develop a ground-breaking class of materials: functional porous polymers able to expand and collapse their volume fully autonomously in a predesigned rhythm for a predesigned duration. The goal of this fellowship is to produce biocompatible rhythmic (pulsatile) materials for medical applications. In particular, for controlled/targeted drug delivery in chronopharmacotherapy to treat diseases with established oscillatory rhythms in their pathogenesis, e.g. arthritis (10 million people in UK), duodenal ulcers (1 in 10 people in UK), cancer (1 in 4 of all deaths in UK) and cardiovascular diseases (1 in 4 adults in UK). Also, for mechanoresponsive tissues (e.g. bone and the vascular system) in regenerative medicine to facilitate cell activity and the assembly of mechanically robust and biologically functional tissue (organs). The proposed methodology incorporates collaboration with BDD (http://www.bddpharma.com/) and internationally recognised academic partners. This will enhance progress, knowledge dissemination, mitigate risks and ensure the materials are suitable for end-user driven development of fit-for-purpose products, and will accelerate transfer of research outcomes to healthcare applications. The proposal is built on the ground-breaking discovery of chemical oscillators employing polymeric substrates (Chem Commun 2014) and in-depth studies of biocompatible intelligent hydrogels (Adv Mater Sci Eng 2015) resulting from CAF2009. The project duration is 2 years and the methodology has 3 work packages (WP). WP1 in collaboration with Professor Vancso's group, Twente University, addresses the synthesis and experimental validation of proof-of-principle autonomous polymeric materials. In WP2, in collaboration with BDD company, characterisation and validation of the materials is pursued to meet end-user needs and regulatory requirements. WP3 in collaboration with Professor Kolar-Anic's group, Belgrade University, focuses on the development of predictive physico-chemical models to aid experimental studies and facilitate the design of patient-tailored materials. The proposal is aligned with Healthcare Technologies Grand Challenges (Developing Future Therapies; Optimising Treatment) and Advanced Materials and Future Manufacturing Technologies areas of research.

该项目旨在开发一种突破性的材料：功能性多孔聚合物，能够在预先设计的时间内以预先设计的节奏完全自主地膨胀和收缩体积。该奖学金的目标是生产生物相容性的节奏（脉动）材料的医疗应用。特别是，用于时辰药物疗法中的受控/靶向药物递送，以治疗在其发病机制中具有既定振荡节律的疾病，例如关节炎（英国1000万人）、十二指肠溃疡（英国1/10人）、癌症（英国所有死亡中的1/4）和心血管疾病（英国1/4成人）。此外，对于再生医学中的机械响应组织（例如骨骼和血管系统），以促进细胞活性和机械稳健和生物功能组织（器官）的组装。拟议的方法包括与BDD（http：//www.bddpharma.com/）和国际公认的学术合作伙伴的合作。这将促进进步，知识传播，降低风险，并确保材料适合最终用户驱动的适用产品开发，并将加速研究成果向医疗保健应用的转移。该提案建立在使用聚合物基质的化学振荡器的突破性发现（Chem Commun 2014）和CAF 2009产生的生物相容性智能水凝胶的深入研究（Adv Mater Sci Eng 2015）的基础上。项目持续时间为2年，方法有3个工作包（WP）。WP 1与Twente大学Vancso教授的团队合作，致力于原理证明自主聚合物材料的合成和实验验证。在WP 2中，与BDD公司合作，对材料进行表征和验证，以满足最终用户需求和法规要求。WP 3与贝尔格莱德大学Kolar-Anic教授的小组合作，专注于开发预测性物理化学模型，以帮助实验研究并促进设计患者定制的材料。该提案与医疗技术大挑战（开发未来疗法;优化治疗）和先进材料和未来制造技术研究领域保持一致。

项目成果

From small molecules to polymeric catalysts in the oscillatory carbonylation reaction: multiple effects of adding HI.

振荡羰基化反应中从小分子到聚合物催化剂：添加 HI 的多重效应。

• DOI: 10.1039/c7cp07747e
• 发表时间: 2018
• 期刊: PCCP
• 作者: Isakova A

Oscillatory carbonylation of poly(ethylene glycol)methyl ether acetylene. Improved model of reaction mechanism

聚乙二醇甲醚乙炔的振荡羰基化。

• DOI: 10.1007/s11144-021-02148-9
• 发表时间: 2022
• 期刊: Reaction Kinetics, Mechanisms and Catalysis
• 作者: Cupic Ž

Design and validation study of a laboratory scale chemical reactor for non-invasive imaging of macro objects in situ

• DOI: 10.1016/j.cej.2017.07.001
• 发表时间: 2017-11
• 期刊: Chemical Engineering Journal
• 影响因子: 15.1
• 作者: D. Marin;M. Fairlie;P. Bunton;C. Nwosu;Julie Faith Parker;F. Franklin;K. Novakovic

Combining polymer-bound catalyst with polymeric substrate for reproducible pH oscillations in palladium-catalysed oxidative carbonylation of alkynes

• DOI: 10.1016/j.eurpolymj.2018.10.038
• 发表时间: 2018-12-01
• 期刊: EUROPEAN POLYMER JOURNAL
• 影响因子: 6
• 作者: Isakova, Anna;Parkes, George E.;Novakovic, Katarina
• 通讯作者: Novakovic, Katarina

Hydrogels - Recent Advances

水凝胶 - 最新进展

• DOI: 10.1007/978-981-10-6077-9_1
• 发表时间: 2018
• 作者: Novakovic K