POLYSULFONATE IMMOBILIZATION FOR THROMBUS PREVENTION

所有与血液接触的合成材料都会引发血栓并激活 纤维蛋白凝固、血小板黏附和补体等过程 激活。由于这些观察，大量的调查已经 已被用于开发非血栓形成材料。这些措施包括 通过添加添加剂对自然表面进行化学修饰 亲水性部分或生物活性底物的固定化。 另一种方法是将阴离子部分结合到 聚合物基质，据报道可导致高度抗血栓形成 浮出水面。 该第一阶段研究项目的目标是利用BSI的专利 光固定化技术共价固定化光反应 将聚丙烯酰胺-聚磺酸聚合物涂覆在各种生物材料上。这些 聚磺酸盐涂层可能会影响蛋白质和血小板 粘连并导致长效抗血栓形成的发展 表面。

All synthetic materials which contact blood are thrombogenic and activate processes such as fibrin coagulation, platelet adhesion, and complement activation. Because of these observations, numerous investigations have been conducted to develop nonthrombogenic materials. These include chemical modifications of the natural surface by the addition of hydrophilic moieties or immobilization of biologically active substrates. An alternative approach would be to incorporate anionic moieties into the polymer matrix, which is reported to result in a highly antithrombogenic surface. The goal of this Phase I research project is to utilize BSI's proprietary photoimmobilization technology to covalently immobilize photoreactive polyacrylamide-polysulfonate polymers onto various biomaterials. These polysulfonate coatings will potentially affect protein and platelet adhesion and lead to the development of long-lasting antithrombogenic surfaces.