POLYSULFONATE IMMOBILIZATION FOR THROMBUS PREVENTION

聚磺酸盐固定预防血栓

• 批准号: 3502379
• 负责人: PETER H DUQUETTE
• 金额: $ 5万
• 依托单位: SURMODICS, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1994-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3502379
• 关键词: anions; antithrombogenic surface; biomaterial development /preparation; cell adhesion; clotting factor; coagulation factor X; fibrinogen; human subject; hydropathy; photoactivation; platelet activation; polymers; polyurethanes; polyvinyls; prothrombin time; scanning electron microscopy; silicone rubber; sulfonate; thrombin

All synthetic materials which contact blood are thrombogenic and activate processes such as fibrin coagulation, platelet adhesion, and complement activation. Because of these observations, numerous investigations have been conducted to develop nonthrombogenic materials. These include chemical modifications of the natural surface by the addition of hydrophilic moieties or immobilization of biologically active substrates. An alternative approach would be to incorporate anionic moieties into the polymer matrix, which is reported to result in a highly antithrombogenic surface. The goal of this Phase I research project is to utilize BSI's proprietary photoimmobilization technology to covalently immobilize photoreactive polyacrylamide-polysulfonate polymers onto various biomaterials. These polysulfonate coatings will potentially affect protein and platelet adhesion and lead to the development of long-lasting antithrombogenic surfaces.

所有与血液接触的合成材料都是血栓形成和活化的 过程，如纤维蛋白凝固，血小板粘附和补体 activation. 由于这些观察，许多调查 用于开发非血栓形成材料。 这些包括 通过添加以下物质对天然表面进行化学改性 亲水部分或生物活性底物的固定。 另一种方法是将阴离子部分引入到聚合物中。 聚合物基质，据报道，这导致高度抗血栓形成 面 第一阶段研究项目的目标是利用BSI的专有技术， 光固定化技术， 聚丙烯酰胺-聚磺酸盐聚合物到各种生物材料上。这些 聚磺酸盐涂层可能会影响蛋白质和血小板 粘附，并导致持久的抗血栓形成的发展 表面。