CYCLODEXTRINS FOR SLOW-RELEASE ANTIBIOTIC COATING

描述：（改编自申请人摘要）。 它所说的 基于聚合物的植入式设备，例如尿路 导管、人工晶状体、血管移植物和起搏器导线 占所有非骨科植入式器械的80%， 预计在未来会增加。 不幸的是，聚合物表面 天生就有着惊人的高器械感染率。 由于常规抗生素的全身治疗 导致足够高的局部浓度， 这种类型的感染，昂贵的再手术器械移除， 几乎总是必要的。 因为严重的外科手术 并发症，抗生素缓释表面处理， 装置将减轻可植入装置的主要问题。 这个第一阶段研究项目的目标是利用生物计量学 系统公司的专利光固化技术， 共价包合环糊精 包合物 具体 在模型疏水支持基质上，例如尿 导管 这些缓释抗菌涂层将 潜在地降低以器械为中心的感染的发生率， 表现出明显优于目前使用的方法的优点。

DESCRIPTION: (Adapted from the Applicant's Abstract). It is stated that polymer-based implantable devices, such as urinary tract catheters, intraocular lenses, vascular grafts,and pacemaker leads comprise 80% of all non-orthopedic implantable devices and the number is expected toincrease in the future. Unfortunately, polymer surfacesare inherentlysubject to alarmingly high device-centered infection rates. Since systemic treatment with conventional antibiotics doesnot resultin sufficiently high local concentrations to effectively treat this type of infection, expensive reoperative device removal is virtually always necessary. Because of the serious surgical complications, antibiotic slow-release surface treatments for implantable devices would alleviate a major problem with implantable devices. The goal of this Phase I research project is to utilize Bio-Metric Systems, Inc.'s proprietary photoimmobilization technology to covalently immobilize cyclodextrin inclusion complexesof specific antibioticsonto model hydrophobic support matrices, such as urinary tract catheters. These slow-release antimicrobial coatings will potentially reduce the incidence of device-centered infections and exhibit distinct advantages over currently used procedures.