CYCLODEXTRINS FOR SLOW-RELEASE ANTIBIOTIC COATING

用于缓释抗生素包衣的环糊精

• 批准号: 3489314
• 负责人: PETER H DUQUETTE
• 金额: $ 5万
• 依托单位: SURMODICS, INC.
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1993-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3489314
• 关键词: antibiotics; bacterial disease; biomaterials; cyclodextrins; implant; photochemistry; polymers; slow release drug; surface property

DESCRIPTION: (Adapted from the Applicant's Abstract). It is stated that polymer-based implantable devices, such as urinary tract catheters, intraocular lenses, vascular grafts,and pacemaker leads comprise 80% of all non-orthopedic implantable devices and the number is expected toincrease in the future. Unfortunately, polymer surfacesare inherentlysubject to alarmingly high device-centered infection rates. Since systemic treatment with conventional antibiotics doesnot resultin sufficiently high local concentrations to effectively treat this type of infection, expensive reoperative device removal is virtually always necessary. Because of the serious surgical complications, antibiotic slow-release surface treatments for implantable devices would alleviate a major problem with implantable devices. The goal of this Phase I research project is to utilize Bio-Metric Systems, Inc.'s proprietary photoimmobilization technology to covalently immobilize cyclodextrin inclusion complexesof specific antibioticsonto model hydrophobic support matrices, such as urinary tract catheters. These slow-release antimicrobial coatings will potentially reduce the incidence of device-centered infections and exhibit distinct advantages over currently used procedures.

描述：（改编自申请人的摘要）。 据称 基于聚合物的可植入装置，例如尿路 导管、人工晶状体、血管移植物和起搏器导线 占所有非骨科植入设备的 80%，数量为 预计未来还会增加。 不幸的是，聚合物表面 本质上受到以设备为中心的高得惊人的感染率的影响。 由于常规抗生素的全身治疗不能 产生足够高的局部浓度以有效治疗 这种类型的感染，需要昂贵的再次手术装置去除 实际上总是必要的。 因为严重的手术 并发症、植入式抗生素缓释表面处理 设备将缓解植入式设备的一个主要问题。 该第一阶段研究项目的目标是利用生物识别技术 Systems, Inc. 专有的光固定技术 共价固定特定环糊精包合物 抗生素森托模型疏水支持基质，例如尿 道导管。 这些缓释抗菌涂层将 可能减少以设备为中心的感染的发生率 与目前使用的程序相比表现出明显的优势。