DEVELOPMENT OF INSTRUMENTS TO MEASURE HUMAN EXPOSURE

开发测量人体暴露的仪器

• 批准号: 3507559
• 负责人: JOSEPH R STETTER
• 金额: $ 21.06万
• 依托单位: TRANSDUCER RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-07 至 1992-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3507559
• 关键词: air sampling /monitoring; dosage; environmental contamination; epidemiology; gas poisoning; injury prevention; monitoring device; occupational hazard; online computer; poison control; radiation dosage

This Phase II research will develop miniature dosimeters for measuring and recording the concentrations of toxic gases at very low levels. These dosimeters are of interest to researchers in the exposure assessment field, and will also find use in industrial hygiene. In this study, we will develop and test recording dosimeters for carbon monoxide, nitrogen dioxide, hydrogen sulfide, formaldehyde, and ethylene oxide. These dosimeters will employ miniaturized amperometric gas sensors and even smaller microfabricated sensors and will be capable of such sophisticated controlled-potential measurements as cyclic voltammetry. Phase I research has demonstrated that cyclic voltammetry using microsensors can be used to distinguish hydrogen sulfide from sulfur dioxide as well as giving quantitative information. Presently-available technology can be used to develop recording dosimeters that are less than 5 cubic inches in size and will accumulate data for at least a week.

第二阶段的研究将开发微型剂量计， 记录了非常低的有毒气体浓度。这些 剂量计是暴露评估领域的研究人员感兴趣的， 并且还将在工业卫生中得到应用。在这项研究中，我们将 开发和测试一氧化碳、氮气 二氧化物、硫化氢、甲醛和环氧乙烷。这些 剂量计将采用小型化的安培气体传感器， 更小的微型传感器，并将能够这样复杂的 控制电位测量作为循环伏安法。I期研究 已经证明使用微传感器的循环伏安法可以用于 区分硫化氢和二氧化硫， 定量信息。现有技术可用于 开发尺寸小于5立方英寸的记录剂量计， 将积累至少一周的数据。