SOLID STATE ENZYME-BASED IMMUNOSENSORS
SOLID STATE ENZYME-BASED IMMUNOSENSORS
批准号:
3506055
负责人:
RICHARD H SMITH
金额:
$23.52万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1988
资助国家:
美国
项目状态:
已结题
起止时间:
1988-05-01 至 1992-05-31
中文摘要
这项SBIR研究的目标是开发一种新的,通用的,
具有快速、现场
流体中生物学重要分子的定量测定
例如血液、血浆、血清、唾液和尿液。 该原则基于
一种酶放大免疫电化学固相检测器,
可以耦合到不同的前置放大器系统。 可行性
在第一阶段展示。 完成后,用户只需注入
将样本放入分析物专用的一次性检测盒中,并将其插入
分析模块 几分钟后,测得的浓度将为
显示. 第二阶段的研究将侧重于优化系统;
开发一种易于使用的仪器,避免了移液的需要;
开发和测试原型系统,
支持商业化。 专属性将通过使用
鉴别抗分析物单克隆抗体和灵敏度,
酶扩增和安培检测产生的反应
产品. 该传感器具有成本低、电极稳定性好等特点
(可忽略的结垢)、一步操作和使用点校准。
如果传感器系统如我们预期的那样工作,
传感器可以扩展到广泛的检测和定量
包括环境毒素,传染性病原体,
抗体、滥用药物、诊断生物分子和治疗药物。
英文摘要
The objective of this SBIR research is to develop a new, generic,
immunoelectrochemical sensor system with capabilities for rapid, on-site,
quantitative determination of biologically important molecules in fluids
such as blood, plasma, serum, saliva, and urine. The principle is based on
an enzyme-amplified, immunoelectrochemical, solid phase detector that can
be coupled to different reporter-amplifier systems. Feasibility was
demonstrated in Phase I. When complete, a user should only need to inject
a sample into an analyte-specific, disposal cartridge and insert it into an
analytical module. After a few minutes the measured concentration will be
displayed. Phase II research will focus on optimizing the system;
developing an easily-used instrument that obviates the need for pipetting;
and developing and testing prototype systems able to attract Phase III
support for commercialization. Specificity will be achieved through use of
discriminating anti-analyte monoclonal antibodies and sensitivity through
enzyme amplification and amperometric detection of generated reaction
products. The developed sensor will feature low cost, electrode stability
(negligible fouling),l one-step operation, and point of use calibration.
If the sensor system functions as we anticipate, the capability of the
sensor could be extended to the detection and quantitation of a wide
variety of agents including environmental toxins, infectious agents,
antibodies, drugs of abuse, diagnostic biomolecules and therapeutic drugs.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Rational, Computational Design of Novel anti-AIDS Drugs
-
批准号:6653698
-
项目类别:
-
资助金额:$13.45万
-
财政年份:2003
-
负责人:RICHARD H SMITH
-
依托单位:
Integrated Fiber Optic Sensor for DNA Hydridization
-
批准号:6655638
-
项目类别:
-
资助金额:$29.74万
-
财政年份:2000
-
负责人:RICHARD H SMITH
-
依托单位:
INTEGRATED FIBER OPTIC SENSOR FOR DNA HYBRIDIZATION
-
批准号:6073649
-
项目类别:
-
资助金额:$10.66万
-
财政年份:2000
-
负责人:RICHARD H SMITH
-
依托单位:
Integrated Fiber Optic Sensor for DNA Hydridization
-
批准号:6551352
-
项目类别:
-
资助金额:$44.04万
-
财政年份:2000
-
负责人:RICHARD H SMITH
-
依托单位:
BIOSENSOR STUDIES OF ESTROGENIC COMPOUNDS WITH HER-A & B
-
批准号:6015289
-
项目类别:
-
资助金额:$10.0万
-
财政年份:1999
-
负责人:RICHARD H SMITH
-
依托单位:
NOVEL BINDING MOLECULES FOR OPIOID PEPTIDES
-
批准号:2717631
-
项目类别:
-
资助金额:$10.0万
-
财政年份:1998
-
负责人:RICHARD H SMITH
-
依托单位:
FIBER OPTIC SENSOR FOR ENVIRONMENTAL PSEUDOESTROGENS
-
批准号:6204646
-
项目类别:
-
资助金额:$1.18万
-
财政年份:1996
-
负责人:RICHARD H SMITH
-
依托单位:
SUBJECTIVE UNFAIRNESS AND ENVIOUS HOSTILITY
-
批准号:3430335
-
项目类别:
-
资助金额:$5.58万
-
财政年份:1992
-
负责人:RICHARD H SMITH
-
依托单位:
SUBJECTIVE UNFAIRNESS AND ENVIOUS HOSTILITY
-
批准号:3430336
-
项目类别:
-
资助金额:$5.15万
-
财政年份:1992
-
负责人:RICHARD H SMITH
-
依托单位:
DRUGS OF ABUSE IN SALIVA
-
批准号:3507115
-
项目类别:
-
资助金额:$24.1万
-
财政年份:1990
-
负责人:RICHARD H SMITH
-
依托单位:
SOLID-STATE ENZYME-BASED IMMUNOSENSORS
-
批准号:3506054
-
项目类别:
-
资助金额:$23.47万
-
财政年份:1988
-
负责人:RICHARD H SMITH
-
依托单位:
CARCINOGENIC AND CARCINOSTATIC PROPERTIES OF TRIAZENES
-
批准号:3056729
-
项目类别:
-
资助金额:$0.75万
-
财政年份:1986
-
负责人:RICHARD H SMITH
-
依托单位:
CARCINOGENIC AND CARCINOSTATIC PROPERTIES OF TRIAZENES
-
批准号:3056728
-
项目类别:
-
资助金额:$0.07万
-
财政年份:1986
-
负责人:RICHARD H SMITH
-
依托单位:
CARCINOGENIC AND CARCINOSTATIC PROPERTIES OF TRIAZENES
-
批准号:3056725
-
项目类别:
-
资助金额:$0.02万
-
财政年份:1985
-
负责人:RICHARD H SMITH
-
依托单位:
CARCINOGENIC AND CARCINOSTATIC PROPERTIES OF TRIAZENES
-
批准号:3056723
-
项目类别:
-
资助金额:$0.04万
-
财政年份:1985
-
负责人:RICHARD H SMITH
-
依托单位:
CARCINOGENIC AND CARCINOSTATIC PROPERTIES OF TRIAZENES
-
批准号:3056724
-
项目类别:
-
资助金额:$0.03万
-
财政年份:1985
-
负责人:RICHARD H SMITH
-
依托单位:
CARCINOGENIC AND CARCINOSTATIC PROPERTIES OF TRIAZENES
-
批准号:3056726
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1984
-
负责人:RICHARD H SMITH
-
依托单位:
CARCINOGENIC AND CARCINOSTATIC PROPERTIES OF TRIAZENES
-
批准号:3056727
-
项目类别:
-
资助金额:$0.05万
-
财政年份:1984
-
负责人:RICHARD H SMITH
-
依托单位:
海外基金