FAST DESORPTION AND MASS ANALYSIS OF LARGE MOLECULES

新出现的健康和医学研究问题正在把 对描述不稳定和不稳定的 高分子量有机化合物。在生物技术方面， 例如，必须识别中间合成产品。 最近的离子轰击解吸模型表明，最高 分子量大的化合物解吸效果最好。 通过分子附着附近的快速多重激发 地点。共振电离光谱学有可能 在目标上提供空间受限的初级离子束 皮秒范围。的连续离子到达时间间隔 这个震源与亚皮秒时间相称。 分子运动和能量传递的理论预测 发送到附件站点。这项建议的具体目的是：1) 对热雾化光源和离子引出透镜进行改装以用于 一次共振电离轰击源；2)修改 用于更高分辨率的现有飞行时间质谱仪；3) 评估初级离子脉冲的时间宽度；4) 研究高效解吸超高硫废水的可行性 相对分子质量的物种。潜在的多重激励 建议震源的效率和时间分辨率将 同时为解吸很高的有机物提供了基础 分子和超高分辨率飞行时间质量 分光计。

Emerging health and medical research problems are placing stringent requirements on the ability to characterize labile and high molecular weight organic compounds. In biotechnology, for example, intermediate synthesis products must be identified. Recent ion bombardment desorption models suggest that highest molecular weight compounds would desorb most efficiently through rapid multiple excitations near the molecular attachment site. Resonance ionization spectroscopy has the potential to deliver spatially constrained primary ion bundles on target in the picosecond range. The successive ion arrival time intervals for this source are commensurate with subpicosecond times theoretically predicted for molecular motion and energy transfer to the attachment site. The specific aims of this proposal are: 1) modify a thermal atomization source and ion extraction lens for a primary resonance ionization bombardment source; 2) modify an existing time-of-flight mass spectrometer for higher resolution; 3) evaluate the temporal width of the primary ion pulse; 4) investigate the feasibility of efficient desorption of very high molecular weight species. The potential multiple excitation efficiency and temporal resolution of the proposed source would simultaneously provide the bases for desorption of very high molecules and for an ultra-high resolution time-of-flight mass spectrometer.