ALUMINUM IN BRAIN DISEASES

铝被认为与神经和衰老有关， 包括阿尔茨海默病和透析性痴呆。上一首 痕量分析研究受到干扰和 污染，缺乏元素的特异性、敏感性和 同位素信息。共振电离光谱(RIS)， 利用激光原子计数技术，提供了潜在的 克服这些不利因素，深入探讨 铝在神经生物学中的机械作用。具体目标是 目标：1)开发简化的化学分离和雾化 铝的技术；2)开发共振电离方案 对于铝；3)论证铝的可行性 生物矩阵中的测定；4)说明 这项技术可以用来研究铝在 神经紊乱。在第二阶段，知识和 第一阶段的方法论将应用于以下具体问题 铝在神经生物学中的应用。或许可以评估 假设特定的神经功能障碍是由 铝与亚细胞中特定化学位置的结合 结构。这种能力可能会导致开发一种 一种或多种此类疾病的早期诊断。技术基础 将建立目前用于商业铝分析的 除了最先进的技术，RIS工具将是 向医学界和分析界传播。

Aluminum has been implicated in neurological and aging disorders, including Alzheimer's disease and dialysis dementia. Previous trace analysis studies were subject to interferences and contamination, and lacked elemental specificity, sensitivity, and isotopic information. Resonance ionization spectroscopy (RIS), which utilizes laser atom counting techniques, offers the potential to overcome these disadvantages and to probe deeply the mechanistic role of aluminum in neurobiology. Specific aims are to: 1) develop simplified chemical separation and atomization techniques for aluminum; 2) develop resonance ionization schemes for aluminum; 3) demonstrate the feasibility of aluminum determinations in biological matrices; 4) illustrate how the technology can be applied to investigate the role of aluminum in neurological disorders. In Phase II the knowledge and methodology of Phase I will be applied to specific problems of aluminum in neurobiology. It may be possible to evaluate the hypothesis that specific neurological dysfunctions result from attachment of aluminum to specific chemical sites in subcellular structures. Such a capability could lead to developing a means of early diagnosis of one or more of these disorders. Technical bases will be established for commercial aluminum analyses currently beyond the state-of-the-art, and RIS instrumentation will be disseminated to the medical and analytical communities.