NEONATAL NUTRITION AND RESONANCE IONIZATION SPECTROSCOPY

新生儿营养和共振电离光谱

• 批准号: 3508149
• 负责人: LARRY J MOORE
• 金额: $ 23.75万
• 依托单位: ATOM SCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1990-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3508149
• 关键词: analytical method; atomic absorption spectrometry; biomedical equipment resource; clinical biomedical equipment; developmental nutrition; mass spectrometry; radionuclides; spectrometry; trace elements

The feasibility of trace and ultra-trace element determinations on microliter volumes of blood serum using resonance ionization spectroscopy (RIS) has been established in Phase I. The development of instrumentation, methodology and applications has the potential to further our understanding of the role of trace metals in premature infants. Trace element accumulation in the human fetus occurs during the last trimester of pregnancy, and premature birth interrupts this process at a critical time. Very little is known about trace element nutrition requirements in premature infants, or about the relationship of trace metals to observed dysfunctions, since the amount of blood available is less than 0.1 ml. The specific aims of this proposal are to: 1 design, fabricate and evaluate a commercial prototype instrument on RIS to determine ultramicro quantities of metals; 2) complete a study of trace metals in low birth weight (1000-2000 grams) pre- term infants; 3) develop a methodology for analytical services using ultra-micro techniques and RIS. The technology developed will provide a commercial prototype RIS instrument for ultra- trace element and isotope determinations, and the basis for service analyses for the neonatology and medical communities. The baseline study of trace metals will be the first performed with premature infants using sample sizes less than 0.1 ml.

痕量和超痕量元素测定的可行性 共振电离法测定微量血清的研究 光谱学(RIS)已在第一阶段建立。 仪器、方法和应用的发展 有可能进一步加深我们对 早产儿体内的痕量金属。微量元素积累 人类胎儿发生在怀孕的最后三个月， 而早产会在关键时刻中断这一过程。 人们对微量元素的营养需求知之甚少 在早产儿中，或关于微量金属与 观察到的功能障碍，因为可用血量较少 该方案的具体目的是：1设计， 制造和评估一台商用原型仪器 RIS用于测定超微量金属；2)完成 低出生体重儿(1000-2000克)围产儿微量元素的研究 足月儿；3)制定分析服务的方法 使用超微技术和RIS。已开发的技术 将提供一个商业原型RIS仪器，用于超 痕量元素和同位素测定，以及 为新生儿科和医学界提供服务分析。 将首先进行痕量金属的基线研究 早产儿使用的样本量小于0.1毫升。