Photo-Electro: Transforming Chemical Synthesis, Discovery and Manufacture

光电：改变化学合成、发现和制造

• 批准号: EP/P013341/1
• 负责人: Mike George
• 金额: $ 826.5万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP013341%2F1
• 关键词: Photo; Electro; Transforming; Chemical; Synthesis

Our vision is to use continuous photochemistry and electrochemistry to transform how fine chemicals, agrochemicals and pharmaceuticals are manufactured in the UK. We aim to minimize the amount of chemicals, solvents and processing steps needed to construct complex molecules. We will achieve this by exploiting light and/or electricity to promote more specific chemical transformations and cleaner processes. By linking continuous photochemistry and electro-chemistry with thermal flow chemistry and environmentally acceptable solvents, we will create a toolkit with the power to transform all aspects of chemical synthesis from initial discovery through to chemical manufacturing of high-value molecules. The objective is to increase efficiency in terms of both atoms and energy, resulting in lower cost, low waste, low solvent footprints and shorter manufacturing routes. Historically photo- and electro-chemistry have been under-utilised in academia and industry because they are perceived to be complicated to use, difficult to scale up and engineer into viable processes despite their obvious environmental, energy and cost benefits. We will combine the strategies and the skills needed to overcome these barriers and will open up new areas of science, and deliver a step-change (i) providing routes to novel molecular architectures, hard to reach or even inaccessible by conventional methodologies, (ii) eliminating many toxic reagents by rendering them unnecessary, (iii) minimizing solvent usage, (iv) promoting new methodologies for synthetic route planning. Our proposal is supported by 21 industrial partners covering a broad range of sectors of the chemistry-using industries who are offering £1.23M in-kind support.Therefore, we will study a broad range of reactions to provide a clear understanding of the most effective areas for applying our techniques; we will evaluate strategies for altering the underlying photophysics and kinetics so as to accelerate the efficiency of promising reactions; we will transform our current designs of photochemical and electrochemical reactors, with a combination of engineering, modelling and new fabrication techniques to maximize their efficiency and to provide clear opportunities for scale-up; we will exploit on-line analytics to accelerate the optimisation of continuous photochemical and electrochemical reactions; we will design and build a new generation of reactors for new applications; we will identify the most effective strategies for linking our reactors into integrated multi-step continuous processes with minimized waste; we will demonstrate this integration on at least one synthesis of a representative pharmaceutical target molecule on a larger scale; we will apply a robust series of sustainability metrics to benchmark our approaches against current manufacturing.

我们的愿景是使用连续光化学和电化学来改变精细化学品，农用化学品和药品在英国的生产方式。我们的目标是最大限度地减少构建复杂分子所需的化学品、溶剂和加工步骤。我们将通过利用光和/或电来促进更具体的化学转化和更清洁的工艺来实现这一目标。通过将连续光化学和电化学与热流化学和环境可接受的溶剂相结合，我们将创建一个工具包，该工具包具有将化学合成的各个方面从最初发现到高价值分子的化学制造的能力。其目标是提高原子和能量的效率，从而降低成本，减少浪费，减少溶剂足迹和缩短生产路线。从历史上看，光化学和电化学在学术界和工业界一直没有得到充分利用，因为它们被认为使用复杂，难以扩大规模并设计成可行的工艺，尽管它们具有明显的环境，能源和成本效益。我们将联合收割机的策略和技能需要克服这些障碍，并将开辟新的科学领域，并提供一个步骤的变化（i）提供路线的新的分子结构，难以达到甚至无法通过传统的方法，（ii）消除许多有毒试剂，使他们不必要的，（iii）尽量减少溶剂的使用，（iv）促进新的方法合成路线规划。我们的建议得到了21个工业合作伙伴的支持，这些合作伙伴涵盖了化学品使用行业的广泛领域，他们提供了123万英镑的实物支持。因此，我们将研究广泛的反应，以清楚地了解应用我们技术的最有效领域;我们将评估改变基础物理学和动力学的策略，以加快有希望的反应的效率;我们将改变我们目前的光化学和电化学反应器的设计，结合工程，建模和新的制造技术，以最大限度地提高其效率，并提供扩大规模的明确机会;我们将利用在线分析，以加速连续光化学和电化学反应的优化;我们将设计和建造新一代的反应器，用于新的应用;我们将确定最有效的策略，将我们的反应器连接到集成的多步连续过程中，最大限度地减少浪费;我们将在至少一个较大规模的代表性药物靶分子的合成中展示这种集成;我们将应用一系列强大的可持续性指标来衡量我们的方法对当前制造的基准。

项目成果

UV PhotoVap: Demonstrating How a Simple and Versatile Reactor Based on a Conventional Rotary Evaporator Can Be Used for UV Photochemistry

UV PhotoVap：演示如何将基于传统旋转蒸发器的简单多功能反应器用于紫外光化学

• DOI: 10.1021/acs.oprd.8b00037
• 发表时间: 2018
• 期刊: Organic Process Research & Development
• 影响因子: 3.4
• 作者: Clark C

A new mode of cyclobutenedione ring opening for the synthesis of 2-oxobut-3-enamides and tetrasubstituted furans.

• DOI: 10.1039/d1cc02097h
• 发表时间: 2021-05
• 期刊: Chemical communications
• 影响因子: 4.9
• 作者: Ryan M Bennett;Wei Sun;Dharyl C Wilson;M. Light;D. Harrowven

Bromide-Mediated Silane Oxidation: A Convenient and Practical Counter-Elecrode Process for Undivided Electrochemical Reductions

溴化物介导的硅烷氧化：一种方便实用的用于完整电化学还原的反电极过程

• DOI: 10.26434/chemrxiv-2023-w3l2v
• 发表时间: 2023
• 作者: Avanthay M

Thermally-Stable Imidazolium Dicationic Ionic Liquids with Pyridine Functional Groups

• DOI: 10.1021/acssuschemeng.0c02473
• 发表时间: 2020-06-15
• 期刊: ACS SUSTAINABLE CHEMISTRY & ENGINEERING
• 影响因子: 8.4
• 作者: Clarke, Coby J.;Bui-Le, Liem;Licence, Peter
• 通讯作者: Licence, Peter

Halometallate ionic liquids: thermal properties, decomposition pathways, and life cycle considerations

• DOI: 10.1039/d2gc01983c
• 发表时间: 2022-07-07
• 期刊: GREEN CHEMISTRY
• 影响因子: 9.8
• 作者: Clarke, Coby J.;Baaqel, Husain;Licence, Peter
• 通讯作者: Licence, Peter