MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM

该提案是对生物医学研究的资助申请 研究部门的支持（BRS）补助金计划 建立一个多用户设施， 合成、纯化和低温储存 多肽。 国立台湾大学生物医学研究所 位于加尔维斯顿的德克萨斯大学医学分支（UTMB）接收 来自BRS的支持，授权# DHHS 2S 07 RR 07205-05，因此 有资格申请BRS-DRR补助金。 要求提供资金，用于肽合成器， 高效液相色谱（HPLC）系统和低 温度冷冻机，以提供肽合成能力， 14个记录在案的正在进行的生物医学研究项目，大多数 目前由美国国立卫生研究院资助 （NIH）。 这些项目包括六个涉及分子的项目 配体-受体相互作用的基础，三个项目处理 蛋白质结构与功能的免疫学解剖，三 涉及神经化学的项目和特定的 肽作为神经递质分子，一个项目涉及 保护膜免受自由基的侵害， 涉及肽作为离子通道修饰剂在人工 膜。 收购拟议的肽合成仪是 为了更有效地实现这些目标， NIH批准了项目，并允许这些研究人员扩大 他们的研究努力，以跟上迅速取得的进展 可能通过使用合成肽。 肽合成仪将被安置在附近，并将 与集中的蛋白质化学中心一起运作， 实验室 蛋白质化学实验室已建立 记录正在进行的共享工具使用情况，并具有 处理分担费用的行政机制到位。 一个研究咨询委员会，对学院院长负责。 研究生院将协助项目主任在 肽合成器的行政和科学评论 设施，以确保适当的共享和最大限度地利用这一 仪器仪表 UTMB政府已同意提供 空间，研究助理工资，并继续支持 服务，以操作此设施，允许用户只收取 用于消耗品供应。

This proposal is a grant request to the Biomedical Research Support (BRS) grant program of the Division of Research Resources (DRR) to establish a multi-user facility for automated synthesis, purification and low temperature storage of polypeptides. The Graduate School of Biomedical Sciences of the University of Texas Medical Branch (UTMB) at Galveston receives support from BRS, grant # DHHS 2S07 RR 07205-05 and is thus eligible to apply for a BRS-DRR grant. Funding is requested for a peptide synthesizer, a high performance liquid chromatography (HPLC) system and a low temperature freezer to provide a peptide synthesis capability for 14 documented ongoing biomedical research projects, most of which are currently funded by the National Institutes of Health (NIH). These programs include six projects dealing with molecular basis of ligand-receptor interactions, three projects dealing with immunological dissection of protein structure and function, three projects involving neurochemistry and the nature of specific peptides as neurotransmitter molecules, one project involving membrane protection from free radicals, and one project involving the use of peptides as ion channel modifiers in artificial membranes. Acquisition of the proposed peptide synthesizer is required to more effectively meet the stated objectives of these NIH approved projects and allow these investigators to expand their research efforts to keep pace with the rapid progress made possible by the use of synthetic peptides. The peptide synthesizer will be housed adjacent to, and will be operated in conjunction with, a centralized Protein Chemistry Laboratory. The Protein Chemistry Laboratory has an established record of ongoing shared instrumentation usage and has an administrative mechanism in place for dealing with shared costs. A Research Advisory Committee responsible to the Dean of the Graduate School will assist the Program Director in administrative and scientific review of the peptide synthesizer facility to insure proper sharing and maximizing the use of this instrumentation. The UTMB administration has agreed to provide space, a Research Associate salary, and continued support for service to operate this facility allowing users to be charged only for consumable supplies.