Graphene Sensors for Food Allergen Detection
用于食品过敏原检测的石墨烯传感器
基本信息
- 批准号:EP/P51021X/1
- 负责人:
- 金额:$ 7.85万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2016
- 资助国家:英国
- 起止时间:2016 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Exceptional electronic properties, surface sensitivity & selectivity, inferred by functionalisation, makes graphene ideal for sensor applications. Novel, generic, real-time monitoring sensor technology, based on chemically modified graphene transducers, will be demonstrated for food safety applications, detecting peanut (Ara h 1-9) allergens in food products. Trace quantities of nuts can be present in food processing plants at very low concentrations & can trigger an immune response in allergic individuals, ranging from hives to severe gastrointestinal & respiratory symptoms, & in serious cases - anaphylactic shock.Where there is a possibility of cross-contamination, food producers are obliged to label products or recall incorrectly labelled products - costing industry millions (£5m/recall incidence) & producing negative publicity. Our sensor system, developed for in-situ smart monitoring of food & food processing units, would enable instant and low-cost allergen monitoring. Using chemically modified graphene, integrated into a packaged allergen sensor, for in situ monitoring would offer end-user Unilever a real breakthrough in monitoring for trace nut contaminants.The sensor technology uses a graphene channel functionalised with a receptor molecule - capable of selective & specific detection of a particular allergen. Chemical functionalisation methods, for attaching antibodies to graphene, have already been developed by the consortium. This project will use antibodies targeted against peanut allergens as the receptors. Commercial sensor production requires large area, uniform, electronic-grade graphene - on an insulating substrate. UCAMwill develop "Transfer free" graphene on pre-patterned Ge could providing a step change in graphene electronics. In parallel, work will be performed on graphene grown on copper - transferred onto SiO2/Si wafers - mitigating risk by enabling device and functionalisation work to be completed prior to the availability of graphene/ Germanium. Characterisation of these materials (NPL) is essential to providing uniform graphene with consistent and controlled electrical properties. NPL will analyse layer thicknesses, uniformity, defect densities and electrical performance following growth and also subsequent to chemical modification of graphene. PG will transfer existing graphene device fabrication process to large area CVD graphene on SiO2/Si & pre-patterned graphene on Ge wafers to fabricate graphene Chemical Field Effect Transistors. Chem-FETs comprise a graphene channel, patterned via lithography & subsequent oxygen plasma etch, between two metal (Ti/Au) contacts. Large area fabrication will reduce individual sensor costs. Based on current pricing wafer & processing costs of £1000 & using 4mm square chips, yields a cost of £2.22 per sensor. This could be reduced to £0.55 per chip by using a 2mm square chip. As the price of graphene comes down, this cost could be further reduced. Amine surface chemistry, developed under previous EPSRC grants [OJ Guy], will be used by PG to attach allergen-specific antibodies. Novel electrochemical diazonium functionalisation developed for antibody attachment to graphene will be used along with new plasma amine termination processes, before (a) amide coupling to the antibody & (b) blocking non-specific binding sites. Allergen binding to modified graphenes surface induces a gating effect, which can be electrically/electrochemically detected. PG and NPL will characterise functionalised graphene (XPS, I-V, CV, Raman, SKPM). PG's prototype sensors would ultimately be integrated into a model food processing unit at Unilever & used to detect trace quantities of allergens.
通过官能化推断出的卓越的电子特性、表面灵敏度和选择性使石墨烯成为传感器应用的理想选择。基于化学改性石墨烯换能器的新型通用实时监测传感器技术将用于食品安全应用,检测食品中的花生(Ara h 1-9)过敏原。食品加工厂中的微量坚果浓度很低,可引发过敏个体的免疫反应,从荨麻疹到严重的胃肠道和呼吸道症状,严重的情况下-过敏性休克。如果存在交叉污染的可能性,食品生产商有义务给产品贴上标签或召回贴错标签的产品-造成行业数百万美元的损失(每次召回500万英镑),并产生负面宣传。我们的传感器系统是为食品和食品加工设备的现场智能监测而开发的,可以实现即时和低成本的过敏原监测。将化学改性石墨烯集成到包装的过敏原传感器中进行原位监测,将为最终用户联合利华提供监测微量坚果污染物的真实的突破。传感器技术使用了受体分子功能化的石墨烯通道-能够选择性和特异性检测特定的过敏原。该联盟已经开发了将抗体附着到石墨烯上的化学功能化方法。该项目将使用针对花生过敏原的抗体作为受体。商业传感器生产需要大面积、均匀的电子级石墨烯-在绝缘基底上。UCAM将在预图案化的Ge上开发“无转移”石墨烯,这可能会给石墨烯电子学带来一个飞跃。同时,将对在铜上生长的石墨烯进行研究-转移到SiO2/Si晶片上-通过在石墨烯/锗可用之前完成器件和功能化工作来降低风险。这些材料的表征(NPL)对于提供具有一致和受控电特性的均匀石墨烯至关重要。NPL将分析层厚度,均匀性,缺陷密度和生长后的电气性能,以及石墨烯的化学改性。PG将把现有的石墨烯器件制造工艺转移到大面积CVD SiO2/Si上的石墨烯和Ge晶片上的预图案化石墨烯,以制造石墨烯化学场效应晶体管。Chem-FET包括在两个金属(Ti/Au)接触之间的石墨烯沟道,其经由光刻和随后的氧等离子体蚀刻图案化。大面积制造将降低单个传感器的成本。根据目前的定价晶圆和处理成本为1000英镑,使用4毫米平方芯片,每个传感器的成本为2.22英镑。通过使用2 mm方形芯片,这可以减少到每芯片0.55英镑。随着石墨烯价格的下降,这种成本可能会进一步降低。胺表面化学,根据以前的EPSRC赠款[OJ盖伊]开发,将被PG用于附着过敏原特异性抗体。在(a)酰胺偶联至抗体和(B)阻断非特异性结合位点之前,将沿着新的血浆胺终止过程使用为抗体与石墨烯连接而开发的新型电化学重氮官能化。过敏原结合到改性的石墨烯表面诱导门控效应,其可以被电/电化学检测。PG和NPL将使官能化的石墨烯(XPS、I-V、CV、拉曼、SKPM)发光。PG的原型传感器最终将被集成到联合利华的一个食品加工单元模型中,用于检测微量的过敏原。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Reactive intercalation and oxidation at the buried graphene-germanium interface
- DOI:10.1063/1.5098351
- 发表时间:2019-07-01
- 期刊:
- 影响因子:6.1
- 作者:Braeuninger-Weimer, Philipp;Burton, Oliver;Hofmann, Stephan
- 通讯作者:Hofmann, Stephan
Fast, Non-Contact, Wafer-Scale, Atomic Layer Resolved Imaging of 2D Materials by Ellipsometric Contrast Micrography
通过椭偏对比显微成像对 2D 材料进行快速、非接触式、晶圆级、原子层分辨成像
- DOI:10.17863/cam.27272
- 发表时间:2018
- 期刊:
- 影响因子:0
- 作者:Braeuninger-Weimer P
- 通讯作者:Braeuninger-Weimer P
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Stephan Hofmann其他文献
University of Birmingham Bio-inspired hierarchical polymer fiber-carbon nanotube adhesives
伯明翰大学仿生分层聚合物纤维-碳纳米管粘合剂
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:0
- 作者:
Zhuxia Rong;Yanmin Zhou;Bingan Chen;John Robertson;Walter Federle;Stephan Hofmann;Ullrich Steiner;P. Goldberg‐Oppenheimer;Dr. S Robertson;Hofmann - 通讯作者:
Hofmann
Stephan Hofmann的其他文献
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{{ truncateString('Stephan Hofmann', 18)}}的其他基金
Self-limiting Growth Mechanisms for Stable Monolayer Films of Non-van-der-Waals Oxides
非范德华氧化物稳定单层薄膜的自限生长机制
- 批准号:
EP/V047515/1 - 财政年份:2021
- 资助金额:
$ 7.85万 - 项目类别:
Research Grant
Expanding the Environmental Frontiers of Operando Metrology for Advanced Device Materials Development
扩大先进设备材料开发操作计量的环境前沿
- 批准号:
EP/T001038/1 - 财政年份:2020
- 资助金额:
$ 7.85万 - 项目类别:
Research Grant
Integration of Novel Materials in Spintronic Devices
自旋电子器件中新型材料的集成
- 批准号:
EP/P005152/1 - 财政年份:2016
- 资助金额:
$ 7.85万 - 项目类别:
Research Grant
GRAVIA - Contiguous graphene ultra-barrier films for flexible electronic applications
GRAVIA - 用于柔性电子应用的连续石墨烯超阻隔薄膜
- 批准号:
EP/M507751/1 - 财政年份:2015
- 资助金额:
$ 7.85万 - 项目类别:
Research Grant
CVD enabled Graphene Technology and Devices (GRAPHTED)
支持 CVD 的石墨烯技术和器件 (GRAPHTED)
- 批准号:
EP/K016636/1 - 财政年份:2013
- 资助金额:
$ 7.85万 - 项目类别:
Research Grant
Materials World Network: Novel Catalyst Systems for Carbon Nanotube (CNT) Synthesis and their Underlying Mechanisms
材料世界网络:用于碳纳米管(CNT)合成的新型催化剂系统及其基本机制
- 批准号:
EP/H047565/1 - 财政年份:2010
- 资助金额:
$ 7.85万 - 项目类别:
Research Grant
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