ELECTRON MICROSCOPY JEOL JEM 100CX

本项目拟采购JEM-100CXII TEMSCAN电子显微镜， 换掉一个14岁的TEM 福赛斯牙科中心是最重要的独立研究中心， 牙科的高级研究。 为了保持高标准， 在各种各样的研究工作中取得的成就，它是定期的 需要更新和扩大现有的能力， 仪器;特别是许多研究人员使用设备 代表研究所内的十个部门。 这些部门 包括以下研究领域：釉质发生，几个具体的 与牙病有关的微生物生态学方面， 与牙周健康和疾病相关的微生物群，牙周 局部给药治疗，氟对斑块的影响，置换 龋齿的治疗，釉质溶解性和再矿化，以及 骨的老化特性。 此外，还有几位毕业生 学生项目有关的分化和骨骼的生长，老化的 唾液腺和牙科材料目前正在进行中。 最后 电子显微镜被一些研究人员用于 试验处于初步阶段，有待未来供资。 JEM-100CX可轻松选择TEM明场、暗场、STEM和 SEM二次或反向散射，在每种模式下都具有高分辨率， 便于操作程序。 仪器的快速性和易用性 操作对于用户和操作者都很重要， 在许多实验中使用EM的限制，包括质量控制 涉及长时间程序的样品（例如质粒分离和 表征）。 在各种模式下查看样品的多功能性 增强和强化通过单一模式获得的概念和图像 操作

This proposal is to purchase JEM-100CXII TEMSCAN electron microscope to replace a 14-year-old TEM. Forsyth Dental Center is the foremost independent center for research and advanced study in dentistry. In order to maintain high standards of achievement in a wide variety of research endeavors it is periodically necessary to update and expand the capabilities of existing instrumentation; particularly that equipment utilized by many researchers representing ten departments within the institute. These departments include the following areas of research: amelogenesis, several specific aspects of microbial ecology pertaining to dental disease, identification of microbiota associated with periodontal health and disease, periodontal therapy by local drug delivery, effects of fluoride on plaque, replacement therapy of dental caries, enamel solubility and remineralization, and the properties of bone in aging. Additionally, there are several graduate student projects pertaining to differentiation and growth of bone, aging of salivary glands, and dental materials currently in progress. Finally electron microscopy is used by several investigators on projects in preliminary stages of experimentation pending future funding. The ease of the JEM-100CX to select TEM bright field, dark field, STEM, and SEM secondary or backscatter, with high resolution in each mode, greatly facilitates operation procedures. Rapidity and ease of instrument operation is important to both user and operator in overcoming time constraints in using the EM in many experiments, including quality control of samples involving long procedures (e.g. plasmid isolation and characterization). The versatility to view a sample in various modes enhances and reinforces concepts and images acquired by single mode operation.