Particle Technology Established Career Fellowship Proposal: Characterisation and Evaluation of New Block Copolymer Nanoparticles

粒子技术设立职业奖学金提案:新型嵌段共聚物纳米粒子的表征和评估

基本信息

  • 批准号:
    EP/R003009/1
  • 负责人:
  • 金额:
    $ 213.72万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Fellowship
  • 财政年份:
    2018
  • 资助国家:
    英国
  • 起止时间:
    2018 至 无数据
  • 项目状态:
    已结题

项目摘要

Particle Technology is an important discipline that underpins many industrial sectors, including biomedical applications, latex paints and coatings, engine oil additives, viscosity modifiers (thickeners) and emulsion stabilisation. The Principal Investigator, Prof. Steve Armes, is one of the UK's experts in particle science and technology, with more than thirty years of research experience in this field. In particular, he designs a wide range of microscopic polymer particles on the nano-scale (polymers are long-chain molecules that can be programmed to undergo in situ self-assembly during chain growth). He seeks a four-year EPSRC Particle Technology Established Career Fellowship to devote more time to such research activities, which will be conducted in close collaboration with four UK-based companies (GEO Specialty Chemicals, Scott Bader, Lubrizol & Syngenta), four UK academics and three overseas academics. This will enable him to integrate substantial academic and industrial expertise in order to tackle a range of important scientific problems that could not be addressed by a single researcher. Some of these problems are fundamental in nature, such as investigating the precise mechanism of particle formation during heterogeneous polymerisation or developing very fine particle-stabilised oil droplets that exhibit long-term stability towards droplet coalescence. Other aspects of the outlined research programme have obvious potential applications. These include: (i) the development of next-generation hydrogels for the long-term storage of human stem cells, which have the potential to transform regenerative medicine; (ii) the design of highly anisotropic worm-like particles to act as thickeners for a range of oils in cosmetics formulations; (iii) the elucidation of new high-temperature oil-thickening mechanisms for engine oils, which has the potential to improve fuel economy and hence improve air quality.Prof. Armes is well-known for his synthetic expertise in particle design, but in the past five years he has gained substantial experience of particle characterisation studies. In particular, his research group now use a range of advanced instrumentation such as small-angle X-ray scattering for particle size analysis, assessing gel properties via oscillatory rheology and emulsion processing using a high-pressure microfluidiser. In this Fellowship, the focus will be on particle characterisation and evaluation, with underpinning particle syntheses being performed by the ten PhD students in the Armes group.To oversee this ambitious research programme, Prof. Armes seeks 50% of his salary for four years. The four work packages will be undertaken by the four named highly-experienced post-doctoral scientists, who are all current members of the Armes group. A total of 13 post-doc (wo)man-years is requested, plus sufficient funds to access all the state-of-the-art equipment that will be required to rigorously characterise the size distributions and solution behaviour of these new polymer particles. In addition, funds are requested for travel, an outreach programme targeting local and regional primary schoolchildren, and to organise a two-day workshop.Prof. Armes has worked closely with a wide range of companies and his research has already inspired the development of commercial products by BASF, Cabot and DSM. More recently, a UK SME (Diamond Dispersions) tripled its annual sales and doubled its workforce by implementing informal technical advice provided by Prof. Armes. In 2016 Lubrizol scaled-up his nanoparticle formulations from five grams to twenty kilos per batch and conducted an extensive in-house evaluation of their performance as additives for next-generation engine oils, with pilot plant trials now approved for 2017. Thus Prof. Armes has an excellent track record of commercially-relevant technical innovation that is of tangible value to UK plc. This augurs well for maximising the economic impact of this Fellowship.
粒子技术是一个重要的学科,支撑着许多工业部门,包括生物医学应用,乳胶漆和涂料,发动机油添加剂,粘度调节剂(增稠剂)和乳液稳定。首席研究员Steve Armes教授是英国粒子科学和技术方面的专家之一,在该领域拥有30多年的研究经验。特别是,他在纳米尺度上设计了广泛的微观聚合物颗粒(聚合物是长链分子,可以在链生长过程中进行原位自组装)。他寻求为期四年的EPSRC粒子技术建立职业奖学金,将更多的时间投入到这些研究活动中,这些研究活动将与四家英国公司(GEO Specialty Chemicals,Scott Bader,Lubrizol & Syngenta),四位英国学者和三位海外学者密切合作。这将使他能够整合大量的学术和工业专业知识,以解决一系列单一研究人员无法解决的重要科学问题。这些问题中的一些在本质上是根本性的,例如研究在非均相聚合期间颗粒形成的精确机制或开发对液滴聚结表现出长期稳定性的非常细的颗粒稳定的油滴。概述的研究方案的其他方面显然具有潜在的应用价值。其中包括:(i)开发用于长期储存人类干细胞的下一代水凝胶,这有可能改变再生医学;(ii)设计高度各向异性的蠕虫状颗粒,用作化妆品配方中一系列油的增稠剂;(iii)阐明用于发动机油的新的高温油增稠机理,Armes教授以其在粒子设计方面的合成专业知识而闻名,但在过去五年中,他在粒子特性研究方面积累了丰富的经验。特别是,他的研究小组现在使用一系列先进的仪器,如小角度X射线散射进行粒度分析,通过振荡流变学和使用高压微流仪进行乳液处理来评估凝胶特性。在该奖学金中,重点将放在粒子表征和评估上,由Armes小组的十名博士生进行基础粒子合成。为了监督这个雄心勃勃的研究计划,Armes教授要求他的薪水的50%,为期四年。这四个工作包将由四位经验丰富的博士后科学家负责,他们都是Armes集团的现任成员。总共需要13个博士后(wo)人年,加上足够的资金来获得所有最先进的设备,这些设备将被要求严格验证这些新聚合物颗粒的尺寸分布和溶液行为。此外,还申请了差旅费、针对当地和区域小学生的外展计划以及组织为期两天的研讨会的资金。Armes教授与多家公司密切合作,他的研究已经启发了巴斯夫、卡博特和帝斯曼的商业产品开发。最近,一家英国中小企业(钻石分散体)通过实施Armes教授提供的非正式技术咨询,使其年销售额增加了两倍,劳动力增加了一倍。2016年,路博润将其纳米颗粒配方从每批5克扩大到20公斤,并对其作为下一代发动机油添加剂的性能进行了广泛的内部评估,现已批准在2017年进行中试工厂试验。因此,Armes教授在商业相关的技术创新方面有着出色的记录,这对英国公司来说具有切实的价值。这预示着最大限度地发挥该奖学金的经济影响。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
New Aldehyde-Functional Methacrylic Water-Soluble Polymers.
Enthalpic incompatibility between two steric stabilizer blocks provides control over the vesicle size distribution during polymerization-induced self-assembly in aqueous media.
  • DOI:
    10.1039/d0sc01320j
  • 发表时间:
    2020-10-21
  • 期刊:
  • 影响因子:
    8.4
  • 作者:
    Beattie DL;Mykhaylyk OO;Armes SP
  • 通讯作者:
    Armes SP
RAFT aqueous dispersion polymerization of 4-hydroxybutyl acrylate: effect of end-group ionization on the formation and colloidal stability of sterically-stabilized diblock copolymer nanoparticles
  • DOI:
    10.1039/d1py01562a
  • 发表时间:
    2022-01-06
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Beattie, Deborah L.;Deane, Oliver J.;Armes, Steven P.
  • 通讯作者:
    Armes, Steven P.
Aldehyde-functional thermoresponsive diblock copolymer worm gels exhibit strong mucoadhesion.
  • DOI:
    10.1039/d2sc02074b
  • 发表时间:
    2022-06-15
  • 期刊:
  • 影响因子:
    8.4
  • 作者:
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Steven Armes其他文献

Steven Armes的其他文献

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{{ truncateString('Steven Armes', 18)}}的其他基金

Fundamental Studies of the Drying of Complex Multiphase Aerosol Droplets
复杂多相气溶胶液滴干燥的基础研究
  • 批准号:
    EP/W022214/1
  • 财政年份:
    2023
  • 资助金额:
    $ 213.72万
  • 项目类别:
    Research Grant
Doped-Up: Bio-Inspired Assembly of Single Crystal Nanocomposites
掺杂:单晶纳米复合材料的仿生组装
  • 批准号:
    EP/P005241/1
  • 财政年份:
    2017
  • 资助金额:
    $ 213.72万
  • 项目类别:
    Research Grant
Biocompatible Sterilisable Worm Gels: An Enabling Technology for the Development of Pluripotent Human Stem Cell-based Therapies
生物相容性可灭菌蠕虫凝胶:开发多能人类干细胞疗法的使能技术
  • 批准号:
    EP/L024160/1
  • 财政年份:
    2014
  • 资助金额:
    $ 213.72万
  • 项目类别:
    Research Grant
Nanostructured gels for intervertebral disc load support and directed regeneration
用于椎间盘负载支撑和定向再生的纳米结构凝胶
  • 批准号:
    EP/K030949/1
  • 财政年份:
    2014
  • 资助金额:
    $ 213.72万
  • 项目类别:
    Research Grant
Bio-inspired Approaches to Functional Nano-structured Materials
功能性纳米结构材料的仿生方法
  • 批准号:
    EP/K006290/1
  • 财政年份:
    2013
  • 资助金额:
    $ 213.72万
  • 项目类别:
    Research Grant
Biocompatible Polymer Colloids for Bionanotechnology Applications
用于生物纳米技术应用的生物相容性聚合物胶体
  • 批准号:
    EP/J007846/1
  • 财政年份:
    2011
  • 资助金额:
    $ 213.72万
  • 项目类别:
    Research Grant
BIOMIMETIC SYNTHESIS OF CRYSTALLINE MATERIALS WITH COMPOSITE STRUCTURES
复合结构晶体材料的仿生合成
  • 批准号:
    EP/G007950/1
  • 财政年份:
    2008
  • 资助金额:
    $ 213.72万
  • 项目类别:
    Research Grant
Platform Grant: Novel Polymers and Colloids for Soft Nanotechnology
平台资助:用于软纳米技术的新型聚合物和胶体
  • 批准号:
    EP/E012949/1
  • 财政年份:
    2007
  • 资助金额:
    $ 213.72万
  • 项目类别:
    Research Grant

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