Engineering biomimetic lubrication with mucin

粘蛋白工程仿生润滑

• 批准号: DP150104147
• 负责人: Prof Jason Stokes
• 金额: $ 18.02万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104147
• 关键词: Engineering; biomimetic; lubrication; mucin

Engineering coatings for water to be an effective lubricant is a significant challenge. The project seeks to emulate how nature builds highly lubricating water-rich polymer films on biological surfaces. This is intended to be achieved by directing the self-assembly of mucin macromolecules onto polymer brushes attached to a substrate, and then cross-linking the constituents to obtain a hydrated gel-like lubricating coating. This research is expected to provide new insights on the mechanisms by which mucin-rich fluids lubricate and protect biosurfaces, which is important to human health, nutrition and well-being. It may also lead to new discoveries for engineering surface coatings for biomaterials and nanomaterials.

将水作为有效润滑剂的工程涂料是一项重大挑战。该项目旨在模仿大自然如何在生物表面上构建高度润滑的富水聚合物膜。这旨在通过将粘蛋白大分子的自组装引导到附着于基底的聚合物刷上，然后使组分交联以获得水合凝胶状润滑涂层来实现。这项研究有望为富含粘蛋白的液体润滑和保护生物表面的机制提供新的见解，这对人类健康，营养和福祉至关重要。它还可能导致生物材料和纳米材料的工程表面涂层的新发现。