Combining human genetics with single-cell genomics to unravel the differentiation dynamics of human induced pluripotent stem cells

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We now have the ability to reprogram mature cells from an adult human into pluripotent stem cells, raising the possibility of using a patient’s own cells for treating currently incurable diseases. My project will provide a better understanding of the role genetic variation between people plays in the variability of the expression and regulation of genes between individual cells during the cell differentiation process. I will also develop statistical and software tools to conduct these analyses.