Combining human genetics with single-cell genomics to unravel the differentiation dynamics of human induced pluripotent stem cells

将人类遗传学与单细胞基因组学相结合，揭示人类诱导多能干细胞的分化动力学

• 批准号: nhmrc : 1112681
• 金额: $ 24.24万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/combining-human-genetics-stem-cells/663226
• 关键词: Combining; human; genetics; single; cell

We now have the ability to reprogram mature cells from an adult human into pluripotent stem cells, raising the possibility of using a patient’s own cells for treating currently incurable diseases. My project will provide a better understanding of the role genetic variation between people plays in the variability of the expression and regulation of genes between individual cells during the cell differentiation process. I will also develop statistical and software tools to conduct these analyses.

我们现在有能力将成人的成熟细胞重新编程为多能干细胞，从而增加了使用患者自己的细胞治疗目前无法治愈的疾病的可能性。我的项目将更好地理解人与人之间的遗传差异在细胞分化过程中单个细胞之间基因表达和调控的差异中所起的作用。我还将开发统计和软件工具来进行这些分析。