Combining laboratory and computational approaches to develop reliable low cost HIV prognostics

结合实验室和计算方法来开发可靠的低成本 HIV 预测

• 批准号: nhmrc : GNT1112885
• 负责人: Dr Kieran Cashin
• 金额: $ 31.46万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/combining-laboratory-computational-hiv-prognostics/1346826
• 关键词: Combining; laboratory; computational; approaches; develop

Certain anti-HIV drugs called 'CCR5 antagonists' block HIV entry into immune cells. However, HIV drug-resistance can occur. Globally, patient access to CCR5 antagonists has been limited because the pre-treatment laboratory test required to determine HIV drug-resistant is expensive and time-consuming. My research will lead to development of computer programs that reliably, rapidly and cheaply determine HIV drug-resistance and thus greatly improve patient access to CCR5 antagonists worldwide.

某些被称为“CCR5拮抗剂”的抗HIV药物可以阻止HIV进入免疫细胞。然而，艾滋病毒可能会产生抗药性。在全球范围内，患者获得CCR5拮抗剂的机会一直受到限制，因为确定艾滋病毒耐药性所需的治疗前实验室测试既昂贵又耗时。我的研究将导致开发可靠、快速和廉价地确定艾滋病毒耐药性的计算机程序，从而极大地改善患者获得世界各地CCR5拮抗剂的机会。