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Optically controlled fluid flow: enabling smart paper-based medical diagnostic devices

光学控制流体流动：实现智能纸质医疗诊断设备

基本信息

批准号：
EP/S003398/1
负责人：
Robert Eason
金额：
$ 55.93万
依托单位：
University of Southampton
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2018
资助国家：
英国
起止时间：
2018 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FS003398%2F1
关键词：
Optically controlled fluid flow enabling

项目摘要

Access to affordable, reliable, user-friendly and rapid medical diagnostic tests has been identified by the World Health Organization (WHO) as a global imperative. In both the developed and developing world, point-of-care (POC) devices are the diagnostic tool of choice, where an answer is provided in a matter of minutes to questions that currently address the relatively straightforward conditions relating to pregnancy or diabetes. Affordable, but user-friendly testing must also be directed to other major complaints and conditions such as HIV, Hepatitis, Malaria, TB and a range of allergies. Moving beyond a simple binary yes/no result, as for a pregnancy test, to tests that provide a quantitative or semi-quantitative result is a global imperative and together with the added demands for greatly enhanced sensitivity and limit of detection are the holy-grail for the diagnostic industry. A multi-testing environment in a paper-based format, where fluid flow can be routed, delayed, gated and mixed will implement these provisions and optimize the outcome of the testing procedure. This is the aim of our novel optically-assisted gated fluid flow technology, which will usher in a much-needed transformative breakthrough that hugely expands the application-domain of fluidics-based diagnostic devices namely lateral flow devices (LFDs) and paper-based analytical devices. While paper-based fluidic devices that rely on their current passive self-wicking process can address some basic functionalities , enabling triggerable on-demand fluid flow using responsive photopolymers will provide a hugely significant step-change in their diagnostic capability through inclusion of the following features : (a) incubation of fluidic sample with a desired biochemical reagent within a channel to maximize the sensitivity and limit of detection; (b) timed on/off gating to allow dispensing of pre-determined sample volume for semi-quantitative detection; (c) triggering-on the sample flow at a desired time for controlled and user-friendly testing and (d) dynamic flow control within multiple flow channels to enable multistep reactions. Our proposal is to develop a paper platform where liquid flow can be controllably switched on and off via non-contact illumination of responsive photopolymers using low power optical addressing. Such a capability will massively transform the current passive lateral flow devices (LFDs) into true lab-on-chip type multi-functional test-beds bringing immediate and quantifiable impact within the medical diagnostic and healthcare sectors.

世界卫生组织（世卫组织）已将获得负担得起、可靠、方便用户和快速的医疗诊断检测确定为全球当务之急。在发达国家和发展中国家，床旁（POC）设备都是首选的诊断工具，在几分钟内就可以回答目前解决与妊娠或糖尿病相关的相对简单的问题。负担得起，但用户友好的测试也必须针对其他主要的投诉和条件，如艾滋病毒，肝炎，疟疾，结核病和一系列过敏。超越简单的二元是/否结果，如妊娠测试，提供定量或半定量结果的测试是全球性的当务之急，以及对大大增强的灵敏度和检测限的额外需求是诊断行业的圣杯。一个基于纸张格式的多测试环境，其中流体流可以路由，延迟，门控和混合，将实施这些规定，并优化测试程序的结果。这是我们新型光学辅助门控流体流动技术的目标，该技术将带来急需的变革性突破，极大地扩展了基于流体的诊断设备（即侧流设备（LFD）和纸基分析设备）的应用领域。虽然依赖于其当前的被动自芯吸过程的纸基流体装置可以解决一些基本功能，但是通过包括以下特征，使得能够使用响应性光聚合物的可重复的按需流体流动将在其诊断能力中提供非常显著的阶跃变化：（a）在通道内将流体样品与期望的生化试剂一起温育，以使检测的灵敏度和极限最大化;（B）定时开/关门控，以允许分配用于半定量检测的预定样品体积;（c）在期望的时间开启样品流，以进行受控和用户友好的测试;和（d）多个流动通道内的动态流动控制，以实现多步反应。我们的建议是开发一种纸平台，其中液体流可以通过使用低功率光学寻址的响应光聚合物的非接触式照明来可控地打开和关闭。这种能力将大规模地将目前的被动侧流设备（LFD）转变为真正的芯片实验室型多功能测试平台，为医疗诊断和医疗保健领域带来即时和可量化的影响。