Laser-based engineering of paper for manufacturing fluidic sensors: (Lab-flo)

用于制造流体传感器的基于激光的纸张工程：（Lab-flo）

• 批准号: EP/N004388/1
• 负责人: Robert Eason
• 金额: $ 74.77万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FN004388%2F1
• 关键词: Laser; based; engineering; paper; manufacturing

In 2013 we started work on an 18-month EPSRC feasibility grant entitled 'Laser-printable point-of-care sensors for low-cost medical diagnosis and disease monitoring', which explored laser-based printing of biological materials for applications in the healthcare sector. Our results have attracted the attention of several major international healthcare manufacturers who see the potential of laser-patterning of porous materials like paper for their future product range and who want to work with us to further develop this technology. We are submitting this follow-on proposal to (1) develop a laboratory-standard process for laser-based paper-patterning for fluidic devices, (2) use our technology in trials for a point-of-care diagnostics demonstrator sensor that allows detection of specific diseases such as tuberculosis, as well as dramatically reducing detection limits, (3) extend the technique to incorporate methodologies for fluid delay, multiplexing, and patterning of 3-D devices, and (4) explore applications beyond planar devices in paper, including 'Light-Up Paper' and functionalised fabrics for 'Smart Plasters'.

2013年，我们开始了为期18个月的EPSRC可行性研究项目，题为“用于低成本医疗诊断和疾病监测的激光打印床旁传感器”，该项目探索了基于激光的生物材料打印在医疗保健领域的应用。我们的研究结果吸引了几家主要的国际医疗保健制造商的注意，他们看到了纸张等多孔材料的激光图案化在其未来产品系列中的潜力，并希望与我们合作进一步开发这项技术。我们正在提交这一后续提案，以（1）开发用于流体设备的基于激光的纸张图案化的实验室标准工艺，（2）将我们的技术用于护理点诊断演示传感器的试验，该传感器允许检测特定疾病，如结核病，以及显著降低检测限，（3）将该技术扩展到包括流体延迟，多路复用，和3D设备的图案化，以及（4）探索纸中平面设备以外的应用，包括“发光纸”和“智能石膏”的功能化织物。

项目成果

Laser direct writing of programmable delays for fabrication of paper-based sensors that allow CRP detection

激光直写可编程延迟，用于制造允许 CRP 检测的纸基传感器

• 发表时间: 2016
• 作者: He P.J.W,

Laser-direct-writing to enable filtration in paper-based devices

激光直写可在纸质设备中实现过滤

• DOI: 10.1117/12.2508753
• 发表时间: 2019
• 作者: Galanis P

Fabrication of paper-based microfluidic devices via local deposition of photo-polymer followed by UV curing

通过光聚合物的局部沉积和紫外线固化制造纸基微流体装置

• 发表时间: 2020
• 期刊: 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
• 作者: He P.J.W.

Programmable delay in paper-based devices using laser direct writing

使用激光直写的纸质设备中的可编程延迟

• 发表时间: 2016
• 作者: He P.J.W

Bacterial pathogens detection and antimicrobial resistance testing using paper-based devices for urinary tract infections (UTIS)

使用尿路感染纸基设备进行细菌病原体检测和抗菌药物耐药性测试 (UTIS)

• 发表时间: 2019
• 期刊: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
• 作者: He P.J.W.