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Developing a humanoid bioreactor for tendon tissue engineering

开发用于肌腱组织工程的人形生物反应器

基本信息

批准号：
EP/S003509/1
负责人：
Pierre-Alexis Mouthuy
金额：
$ 152.3万
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2019
资助国家：
英国
起止时间：
2019 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FS003509%2F1
关键词：
Developing humanoid bioreactor tendon tissue

项目摘要

Tendon diseases, like other musculoskeletal disorders, represent a growing social and economic burden as our population is aging. They often result in tears, causing pain and disability. Surgical repairs are performed at an increasing rate but patient's outcomes are not promising, with 40% of repairs failing at the shoulder joint due to poor tissue healing. Patients with major tissue loss have particularly little chances of recovering. A promising repair strategy is the use of engineered tendon grafts. Tissue engineering involves the development of bioreactors that generate tendon tissue in vitro using the patient's cells, scaffolds and mechanical stimulation. However, more advanced bioreactors are needed to provide functional tendon grafts. Current bioreactors mostly provide uniaxial cyclic loadings, while evidence suggests that they should provide multiaxial stresses, similar to those found physiologically. In this context, musculoskeletal humanoid robots have the potential to apply realistic stresses. These robots replicate the inner structures of the human body such as muscles, tendons and bones. They have seen major developments in recent years, making it now possible to consider their use for unexplored applications in medicine. The aim of this research project is to investigate the potential of using musculoskeletal humanoid robots as a platform for musculoskeletal tissue engineering and in particular for tendon engineering. The overall hypothesis is that humanoid robots will enable the provision of physiological mechanical stimulation and that, as a result, they will lead to engineered tendons that are more functional than those produced with current stretch bioreactors. To demonstrate this, we are proposing to: (1) design a flexible bioreactor chamber compatible with musculoskeletal humanoids, (2) adapt an existing humanoid shoulder for our tendon engineering applications, (3) define the loading regimes of the humanoid bioreactor based on shoulder rehabilitation exercises, (4) produce tendon constructs with the novel system and demonstrate improvements compared to current bioreactors. Computational modelling and motion analysis will be used to support our work. This pioneering project is a step towards functional and personalised grafts to improve patient outcomes and reduce costs to the society.

肌腱疾病，像其他肌肉骨骼疾病一样，随着我们人口的老龄化，代表着日益增长的社会和经济负担。它们经常导致眼泪，引起疼痛和残疾。手术修复的比例越来越高，但患者的结果并不乐观，40%的肩关节修复由于组织愈合不良而失败。严重组织损失的病人恢复的机会尤其小。工程肌腱移植是一种很有前景的修复策略。组织工程涉及开发生物反应器，利用患者的细胞、支架和机械刺激在体外产生肌腱组织。然而，需要更先进的生物反应器来提供功能性肌腱移植。目前的生物反应器大多提供单轴循环载荷，而有证据表明它们应该提供多轴应力，类似于生理学上发现的应力。在这种情况下，肌肉骨骼类人机器人具有应用现实压力的潜力。这些机器人可以复制人体的内部结构，如肌肉、肌腱和骨骼。近年来，它们取得了重大进展，现在可以考虑将它们用于医学上尚未开发的应用。本研究项目的目的是研究使用肌肉骨骼类人机器人作为肌肉骨骼组织工程特别是肌腱工程平台的潜力。总体假设是，人形机器人将能够提供生理机械刺激，因此，它们将产生比目前用拉伸生物反应器生产的肌腱功能更强的工程肌腱。为了证明这一点，我们建议：(1)设计一个与肌肉骨骼类人相容的柔性生物反应器室，(2)为我们的肌腱工程应用调整现有的类人肩膀，(3)定义基于肩部康复练习的类人生物反应器的加载机制，(4)用新系统生产肌腱结构，并展示与现有生物反应器相比的改进。计算建模和运动分析将用于支持我们的工作。这个开创性的项目是朝着功能性和个性化移植迈出的一步，可以改善患者的治疗效果，降低社会成本。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Coupling Stokes Flow with Inhomogeneous Poroelasticity

非均匀孔隙弹性耦合斯托克斯流

DOI：
10.1093/qjmam/hbab014
发表时间：
2021
期刊：
The Quarterly Journal of Mechanics and Applied Mathematics
影响因子：
0
作者：
Taffetani M
通讯作者：
Taffetani M

Humanoid robots to mechanically stress human cells grown in soft bioreactors

DOI：
10.1038/s44172-022-00004-9
发表时间：
2022-05
期刊：
Communications Engineering
影响因子：
0
作者：
P. Mouthuy;Sarah J B Snelling;Rafael Hostettler;Alona Kharchenko;Sarah Salmon;Alan Wainman;J. Mimpen;C. Paul;A. Carr
通讯作者：
P. Mouthuy;Sarah J B Snelling;Rafael Hostettler;Alona Kharchenko;Sarah Salmon;Alan Wainman;J. Mimpen;C. Paul;A. Carr

Advancing Smart Biomedical Textiles with Humanoid Robots

利用人形机器人推进智能生物医用纺织品