CONTRAST facility: clinical coherent Raman scattering facility

对比设施：临床相干拉曼散射设施

• 批准号: EP/S009957/1
• 负责人: Julian Moger
• 金额: $ 131.92万
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FS009957%2F1
• 关键词: CONTRAST; facility; clinical; coherent; Raman

The UK has a rich and vibrant Raman spectroscopy community, which is at the forefront of developments showing that the technique holds the key to the next generation of enabling healthcare technologies. Raman spectroscopy is an established analytical technique that derives information regarding chemical composition based on the vibrational frequency of the chemical bonds within a sample. Due to its unique 'optical fingerprinting' capability, Raman spectroscopy has the potential to play a significant role in healthcare including: histopathology, cytology, biopsy targeting, surgical targets, treatment monitoring and drug studies. However, for many healthcare applications Raman scattering when compared with optical techniques that rely on labelling, has the drawback of being too weak for real-time imaging. Coherent Raman scattering (CRS), is an alternative approach that uses extremely short (approximately one thousandth of one billionth of a second in duration) pulses of lasers to exploit to boost the weak molecular vibrational signals to a level that is compatible with real-time imaging of tissues; a capability that holds the key to the next generation of diagnostic technologies and the development of targeted therapies. We propose to establish a CRS user facility at Exeter that will allow leading UK researchers to develop novel Healthcare Technologies based on this emerging technology.

英国拥有一个丰富而充满活力的拉曼光谱社区，该社区处于发展的前沿，表明该技术掌握着下一代使能医疗技术的关键。拉曼光谱是一种成熟的分析技术，它根据样品中化学键的振动频率得出有关化学成分的信息。由于其独特的“光学指纹”能力，拉曼光谱有可能在医疗保健领域发挥重要作用，包括：组织病理学、细胞学、活组织检查靶标、外科靶标、治疗监测和药物研究。然而，对于许多医疗保健应用来说，与依赖于标记的光学技术相比，拉曼散射具有太弱的缺点，不适合实时成像。相干拉曼散射(CRS)是一种替代方法，它使用极短的(持续时间约为十亿分之一秒)激光脉冲，将微弱的分子振动信号增强到与组织的实时成像兼容的水平；这一能力是下一代诊断技术和靶向治疗开发的关键。我们建议在埃克塞特建立CRS用户设施，允许领先的英国研究人员开发基于这一新兴技术的新型医疗技术。

项目成果

Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer.

• DOI: 10.1039/d2ay01197b
• 发表时间: 2023-03-30
• 期刊: ANALYTICAL METHODS
• 影响因子: 3.1
• 作者: Bouzy, Pascaline;Lyburn, Iain D.;Pinder, Sarah E.;Scott, Robert;Mansfield, Jessica;Moger, Julian;Greenwood, Charlene;Bouybayoune, Ihssane;Cornford, Eleanor;Rogers, Keith;Stone, Nick
• 通讯作者: Stone, Nick

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy.

使用多模态非线性光学显微镜对纳米粒子的细胞摄取进行生物分子成像。

• DOI: 10.3791/63637
• 发表时间: 2022
• 期刊: JoVE
• 作者: Wang CC

Microstructure and antibacterial efficacy of graphene oxide nanocomposite fibres

• DOI: 10.1016/j.jcis.2020.03.037
• 发表时间: 2020-07-01
• 期刊: JOURNAL OF COLLOID AND INTERFACE SCIENCE
• 影响因子: 9.9
• 作者: Matharu, Rupy Kaur;Tabish, Tanveer A.;Edirisinghe, Mohan
• 通讯作者: Edirisinghe, Mohan