New Gas Chromatography-Mass Spectrometry and Fluorescence facilities for the UEA Schools of Chemistry and Pharmacy

东安格利亚大学化学和药学院的新气相色谱-质谱和荧光设施

• 批准号: EP/S017909/1
• 负责人: Fiona Lettice
• 金额: $ 12.74万
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FS017909%2F1
• 关键词: New; Gas; Chromatography; Mass; Spectrometry

To be effective, research in chemical sciences requires access to a very wide range of analytical techniques. Some are used to determine the structure of a molecule, some to determine its properties (for example light absorption or emission, magnetism, biological activity), others enable detection and quantification of known molecules in the environment, in organisms, or in reaction systems, and some can help with all three. As well as varying in their applications and power, these techniques also vary in their speed and ease of use: the most powerful techniques for structural determination are not usually the most appropriate for monitoring a fast reaction.In this proposal, we will increase the range of chemical science feasible at UEA by filling two gaps in our range of analytical techniques. One, GC-MS, will enable us to better monitor reactions as they happen, informing us about their products, by products and mechanisms. Our current method for doing this, NMR, is powerful, but slower, inconvenient, harder to interpret - and the sample preparation required can affect the results. Results provided by the GC-MS will feed through into new and better catalysts and synthetic procedures for useful molecules: for example producing chemical feedstocks from waste products like CO2, or discovering new molecules with potential to act as drugs or as components in new materials.The other, fluorescence/phosphorescence spectroscopy, is at the heart of many projects at the physical science/bioscience interface. Fluorophores and phosphors often change their light emission when they encounter other molecules - emission may be enhanced, switched off, its wavelength or time duration may change. As these changes are often very specific, monitoring emission provides an excellent means to detect biomarkers and other molecules in the environment, cells or organisms - this can contribute to our understanding of biology and biological chemistry and act as a basis for imaging and other diagnostic techniques. The new instrument will add to our capabilities by enabling long-wavelength excitation (useful for tissue penetration) and improved time resolution that can be used to study the fundamental physical processes (energy and electron transfer) underpinning these applications. It will also be useful for investigating the light emission properties of new materials we make for application in devices - such as displays, or optical telecommunications.

为了有效，化学科学的研究需要获得非常广泛的分析技术。一些用于确定分子的结构，一些用于确定其性质（例如光吸收或发射，磁性，生物活性），其他能够检测和定量环境中，生物体中或反应系统中的已知分子，还有一些可以帮助所有三个。这些技术的应用和能力各不相同，它们的速度和用途：最强大的结构测定技术通常并不适用于监测快速反应。在本提案中，我们将通过填补我们分析技术范围内的两个空白来增加UEA可行的化学科学范围。一种是GC-MS，它将使我们能够更好地监测反应的发生，告诉我们它们的产物、副产物和机制。我们目前使用的核磁共振方法非常强大，但速度较慢，不方便，难以解释-并且所需的样品制备可能会影响结果。GC-MS提供的结果将用于更好的新型催化剂和有用分子的合成过程：例如，从二氧化碳等废物中生产化学原料，或发现有潜力作为药物或新材料成分的新分子。另一个是荧光/磷光光谱，是物理科学/生物科学接口的许多项目的核心。荧光团和磷光体在遇到其他分子时通常会改变其光发射-发射可能会增强，关闭，其波长或持续时间可能会改变。由于这些变化通常是非常具体的，监测排放提供了一个很好的手段来检测环境，细胞或生物体中的生物标志物和其他分子-这有助于我们理解生物学和生物化学，并作为成像和其他诊断技术的基础。新仪器将通过启用长波长激发（用于组织穿透）和改进的时间分辨率来增加我们的能力，这些时间分辨率可用于研究支撑这些应用的基本物理过程（能量和电子转移）。它也将有助于研究我们在设备中应用的新材料的发光特性-例如显示器或光学电信。