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Multi-inlet comprehensive gas chromatography and high resolution mass spectrometry

多进样口综合气相色谱和高分辨率质谱分析

基本信息

批准号：
EP/S033343/1
负责人：
Graham Langley
金额：
$ 109.07万
依托单位：
University of Southampton
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2019
资助国家：
英国
起止时间：
2019 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FS033343%2F1
关键词：
Multi inlet comprehensive gas chromatography

项目摘要

In its simplest terms mass spectrometry is a technique for weighing compounds or molecules. This is achieved through an initial stage where the neutral compound becomes charged. This is called ionisation, and once ionised, these species (ions) can be separated using magnetic and/or electric fields. For individual compounds analysis can be simple, but when dealing with mixtures other technologies are required. The mixtures need to be separated to identify the individual components; this is fundamentally separation science and there are a number of different ways to undertake this. The most common is called chromatography, which is a method of separating many different forms of chemical mixtures. Separations can be undertaken using gases or liquids. The combination of chromatography and mass spectrometry affords the most powerful modern day instrumentation for the analysis of complex mixtures.This proposal will fund a multiple inlets gas chromatography mass spectrometer. This instrumentation will deliver advanced automated sample introduction techniques, separation of complex mixtures and advanced high resolution mass spectrometry to aid compound identification.The inlets will provide seamless integration and automated sample introduction with no constraints on compatible sample types, e.g. large volume and low volume gases, headspace for gases and vapours above a sample, captured material and a probe to thermally degrade large species, e.g. polymers into measurable components. Gas chromatography (one column) will afford separation of components in mixtures but for highly complex mixtures, 2-dimensional chromatography (two columns) are needed. The different columns enhance the separation of individual compounds and will separate of overlapping compounds.High resolution mass measurement is used to determine the chemical formulae of compounds, this allows for species with the same nominal mass to be separated by differences in their chemical formulae.The combination of cutting edge sample inlets, chromatographic separation and MS capability will deliver qualitative and quantitative analysis of novel and strategically important chemistries across a range of applications, and will be a unique capability within the UK academic sector. It will deliver a system capable of analysing challenging fuels and emissions for trace level materials, and will serve the research of the UK synthetic and catalysis chemistry communities who work with volatile compounds; the UK environmental scientists to detect low level pollutants in complex matrices, air-borne pollutants; and engineers researching the evolution of small organic gases, sulfur etc. The new strategic equipment will support research across the Southern region. The science from the regional partners (Universities of Bath, Portsmouth, Southampton and Swansea) will develop the capability and subsequently be extended to other academic and industry researchers to form a Centre of Excellence to enable high-priority EPSRC research.

简单地说，质谱学是一种称重化合物或分子的技术。这是通过中性化合物带电的初始阶段实现的。这被称为电离，一旦电离，这些物种(离子)可以使用磁场和/或电场来分离。对于单个化合物，分析可能很简单，但当处理混合物时，需要其他技术。混合物需要被分离以确定单独的成分；这从根本上是分离科学，有许多不同的方法来进行这项工作。最常见的是层析，这是一种分离多种不同形式的化学混合物的方法。可以使用气体或液体进行分离。色谱和质谱学的结合为复杂混合物的分析提供了最强大的现代仪器。这项提议将为多进气色谱质谱计提供资金。该仪器将提供先进的自动进样技术、复杂混合物的分离和先进的高分辨率质谱仪，以帮助化合物识别。进气口将提供无缝集成和自动进样，不受兼容样品类型的限制，例如大体积和低体积气体、样品上方气体和蒸汽的顶空空间、捕获材料和用于热降解大物种(例如聚合物)为可测量成分的探头。气相色谱(单柱)将提供混合物中各组分的分离，但对于高度复杂的混合物，需要二维色谱(双柱)。不同的色谱柱增强了单个化合物的分离，并将分离重叠的化合物。高分辨率质量测量用于确定化合物的化学式，这允许具有相同标称质量的物种通过其化学式的差异进行分离。尖端进样、色谱分离和MS功能的组合将在一系列应用中为新的和具有战略重要性的化学物质提供定性和定量分析，这将是英国学术界的一项独特能力。它将提供一个能够分析具有挑战性的燃料和痕量材料排放的系统，并将服务于英国合成和催化化学界的研究，他们致力于挥发性化合物的研究；英国环境科学家检测复杂基质中的低水平污染物、空气污染物；以及研究小型有机气体、硫等演化的工程师。来自地区合作伙伴(巴斯大学、朴茨茅斯大学、南安普顿大学和斯旺西大学)的科学将发展这一能力，并随后扩展到其他学术和行业研究人员，以形成一个英才中心，以支持EPSRC的高优先级研究。