3D Printed, Stand-alone, Colourimetric Indicator Strip (3DCIS) for Non-Invasive, On-demand Chronic Wound Monitoring
3D 打印独立比色指示条 (3DCIS),用于无创、按需慢性伤口监测
基本信息
- 批准号:EP/T007575/1
- 负责人:
- 金额:$ 87.95万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2020
- 资助国家:英国
- 起止时间:2020 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Chronic wounds have been referred to as the 'silent epidemic' that affects a significant proportion, 1-2 %, of the population during their lifetime. The main causes of chronic wounds are: diabetes, burns and pressure ulcers and, as the term 'chronic' suggests, they are not readily cured. Thus, in a recent study almost 42% of leg/foot ulcers had not healed in the previous 6 months and 28% had remained unhealed for a year or longer. In all countries, chronic woundcare places a considerable burden upon the local and national health services. For example, in the UK, some 650,000 patients suffer from some form of chronic wound, resulting in an annual cost of ca. £3 Bn, and in the USA there are about 6.5 M suffers, whose treatment costs ca. £25 Bn pa. Venous ulcers, which usually occur in the legs, account for 70-90% of chronic wounds and mostly affect the elderly. It follows that since the global average life expectancy continues to rise then so too will the number of incidences, and cost, of treatment of chronic wounds. The combined cost to the NHS for their treatment reaches approximately £3 billion per year. There is a clear need for an inexpensive, disposable wound monitoring method that can be: (i) readily incorporated into a wound dressing, thereby rendering it smart and, (ii) able to provide clinicians, nurses and patients with a continuous, or semi-continuous, stream of information about key biomarkers, i.e. biochemical cues, which would help identify the condition/status of the wound and so flag up wounds that are not healing properly and that require medical intervention. The proposed technology involves the 3D printing of a multi-analyte strip, comprised of four different colour-based indicators which are selective in response to four different gaseous bio-markers, namely: CO2, volatile amines (RNH2), humidity (H2O) and O2. This strip will provide a semi-continuous, on-demand, stream of information concerning the composition of the headspace above the wound and contained by the dressing. The proposed multi-analyte, in situ, volatile analysis, afforded by this simple, stand-alone, colour strip, has a number of advantages compared to existing wound monitoring methods, which include: (1) complete strip production using 3D printing technology, (2) simple colour changes that can be read by eye or digital camera, (3) simple to incorporate into an existing wound dressing (i.e. stand-alone), (4) easy to interpret, (5) logged data trends and automatic real-time alerts (6) inexpensive, (7) non-contact/non-invasive, (8) applicable in a wide number of healthcare environments (including: point of care, outpatients, hospital wards and home care), (9) scope for application in other areas, both medical, such as in acute wound dressings, and non-medical, such as food and electronic goods packaging, (10) amenable to microfabrication and (11) scope for other analytes to be added, such as temperature and volatile sulfides.
慢性伤口被称为“沉默的流行病”,在其一生中影响很大比例的人口,1- 2%。慢性伤口的主要原因是:糖尿病,烧伤和压力溃疡,正如术语“慢性”所暗示的,它们不容易治愈。因此,在最近的一项研究中,近42%的腿部/足部溃疡在过去6个月内没有愈合,28%的溃疡持续了一年或更长时间。在所有国家,慢性伤口护理都给地方和国家卫生服务带来相当大的负担。例如,在英国,大约650,000名患者患有某种形式的慢性伤口,导致每年约1000美元的费用。30亿英镑,在美国大约有650万患者,他们的治疗费用约为100万美元。250亿英镑。静脉溃疡通常发生在腿部,占慢性伤口的70-90%,主要影响老年人。因此,由于全球平均预期寿命持续上升,因此慢性伤口治疗的发病率和成本也将上升。NHS治疗他们的总成本每年达到约30亿英镑。显然需要一种廉价的一次性伤口监测方法,该方法可以:(i)容易地结合到伤口敷料中,从而使其智能,以及(ii)能够为临床医生、护士和患者提供关于关键生物标志物(即生化线索)的连续或半连续信息流,这将有助于识别伤口的状况/状态,从而标记出没有适当愈合并且需要医疗干预的伤口。所提出的技术涉及多分析物条带的3D打印,该条带由四种不同的基于颜色的指示剂组成,这些指示剂对四种不同的气体生物标记物(即CO2、挥发性胺(RNH 2)、湿度(H2O)和O2)具有选择性。该条将提供关于伤口上方和敷料所含顶部空间组成的半连续、按需信息流。与现有的伤口监测方法相比,由这种简单、独立的色带提供的所提出的多分析物、原位、挥发性分析具有许多优点,包括:(1)使用3D打印技术完成条带生产,(2)可以通过眼睛或数码相机读取的简单颜色变化,(3)易于并入现有伤口敷料中(即独立),(4)易于解释,(5)记录的数据趋势和自动实时警报,(6)便宜,(7)非接触/非侵入,(8)可应用于大量的医疗保健环境(包括:护理点、门诊病人、医院病房和家庭护理),(9)在其他领域的应用范围,包括医疗领域,例如急性伤口敷料,和非医疗的,例如食品和电子产品包装,(10)适合于微加工和(11)添加其它分析物的范围,例如温度和挥发性硫化物。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Non-invasive, 3D printed, colourimetric, early wound-infection indicator.
非侵入性、3D 打印、比色、早期伤口感染指示器。
- DOI:10.1039/d1cc06147j
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Yusufu D
- 通讯作者:Yusufu D
A smart sensor for monitoring antimicrobial interventions in wound infections
- DOI:10.1016/j.snb.2023.135179
- 发表时间:2024-04-15
- 期刊:
- 影响因子:8.4
- 作者:Magee,Erin;Yusufu,Dilidaer;Gilmore,Brendan F.
- 通讯作者:Gilmore,Brendan F.
Simple, reusable, solid-state system for measuring total (aerobic) viable count, TVC, using the micro-respirometry method (µRM)
简单、可重复使用的固态系统,用于使用微呼吸测量法 (µRM) 测量总(有氧)活菌数 TVC
- DOI:10.1016/j.snb.2024.135435
- 发表时间:2024
- 期刊:
- 影响因子:0
- 作者:Watson M
- 通讯作者:Watson M
Enhancing the Performance of Two Different Commercial CO2 Indicators Using Digital Colourimetric Analysis, DCA
- DOI:10.3390/chemosensors10120544
- 发表时间:2022-12-01
- 期刊:
- 影响因子:4.2
- 作者:McDonnell, Lauren;Yusufu, Dilidaer;Mills, Andrew
- 通讯作者:Mills, Andrew
3D printed O2 indicators.
- DOI:10.1039/d0an00809e
- 发表时间:2020-05
- 期刊:
- 影响因子:0
- 作者:D. Yusufu;R. Han;A. Mills
- 通讯作者:D. Yusufu;R. Han;A. Mills
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Andrew Mills其他文献
Effects of mobile game playing time on stress response, cognitive function, and visual short-term memory in healthy university students
手机游戏时间对健康大学生压力反应、认知功能和视觉短期记忆的影响
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
Papatsorn Ramyarangsi;Praewpan Buaprapahn;Premika Senwandee;Nichanan Sirisoonthorn;Pasutha Chalermthamrong;Mark Willems;Andrew Mills;Amornpan Ajjimaporn - 通讯作者:
Amornpan Ajjimaporn
Author's response to reviews Title: A new brace treatment similar for adolescent scoliosis and kyphosis based on restoration of thoracolumbar lordosis. Radiological and subjective clinical results after at least one year of treatment. Authors:
作者对评论的回应 标题:一种基于恢复胸腰椎前凸的新型支具治疗方法,用于治疗青少年脊柱侧凸和脊柱后凸。
- DOI:
- 发表时间:
2012 - 期刊:
- 影响因子:0
- 作者:
S. Negrini;A. Aulisa;P. Černý;J. D. de Mauroy;J. McAviney;Andrew Mills;S. Donzelli;T. Grivas;M. Hresko;T. Kotwicki;H. Labelle;Louise Marcotte;M. Matthews;J. O'brien;E. Parent;N. Price;Rigo Manuel;Luke Stikeleather;M. Vitale;M. Wong;G. Wood;J. Wynne;F. Zaina;M. Bruno;Suncica Bulat Würsching;Ç. Yilgor;P. Cahill;Eugenio Dema;P. Knott;A. Lebel;Grigorii Lein;P. Newton;Brian G. Smith - 通讯作者:
Brian G. Smith
Photo-induced absorption spectroscopy (PIAS) study of the kinetics of water oxidation by P25 TiOsub2/sub using periodate as an electron acceptor
使用高碘酸盐作为电子受体的 P25 TiO₂对水氧化动力学的光致吸收光谱(PIAS)研究
- DOI:
10.1016/j.apcata.2022.118817 - 发表时间:
2022-08-25 - 期刊:
- 影响因子:4.800
- 作者:
James Johnston;Christopher O’Rourke;Andrew Mills - 通讯作者:
Andrew Mills
Hydrogen peroxide vapour indicator
- DOI:
10.1016/j.snb.2008.12.032 - 发表时间:
2009-03-02 - 期刊:
- 影响因子:
- 作者:
Andrew Mills;Pauline Grosshans;Eilidh Snadden - 通讯作者:
Eilidh Snadden
Simple, reusable, emsolid-state/em system for measuring total (aerobic) viable count, TVC, using the micro-respirometry method (μRM)
简单,可重复使用的Emsolid-State/EM系统,用于测量总(有氧)可行计数,TVC,使用微呼吸法(μRM)
- DOI:
10.1016/j.snb.2024.135435 - 发表时间:
2024-05-01 - 期刊:
- 影响因子:7.700
- 作者:
Michaella Watson;Dilidaer Yusufu;Andrew Mills - 通讯作者:
Andrew Mills
Andrew Mills的其他文献
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{{ truncateString('Andrew Mills', 18)}}的其他基金
Light-activated, disposable antiviral and antimicrobial plastic films for PPE and other applications
用于个人防护装备和其他应用的光激活一次性抗病毒和抗菌塑料薄膜
- 批准号:
EP/V041541/1 - 财政年份:2020
- 资助金额:
$ 87.95万 - 项目类别:
Research Grant
Sustainable Oxidation Catalysts for the Production of Solar Hydrogen and Chlorine from Brine
用于从盐水中生产太阳能氢和氯的可持续氧化催化剂
- 批准号:
EP/M008061/1 - 财政年份:2015
- 资助金额:
$ 87.95万 - 项目类别:
Research Grant
Photocatalysis for Organic Synthesis
有机合成光催化
- 批准号:
EP/I003800/2 - 财政年份:2011
- 资助金额:
$ 87.95万 - 项目类别:
Research Grant
Nanocrystalline Water Splitting Photodiodes II: Device Engineering, Integration and Scale-up
纳米晶水分解光电二极管 II:器件工程、集成和放大
- 批准号:
EP/J500148/1 - 财政年份:2011
- 资助金额:
$ 87.95万 - 项目类别:
Research Grant
Development of novel, UV-activated, intelligent inks for food packaging
开发用于食品包装的新型紫外线激活智能油墨
- 批准号:
EP/F063725/2 - 财政年份:2011
- 资助金额:
$ 87.95万 - 项目类别:
Research Grant
Bright IDEAS Award: Intelligent pigments and plastics
Bright IDEAS 奖:智能颜料和塑料
- 批准号:
EP/H048170/2 - 财政年份:2011
- 资助金额:
$ 87.95万 - 项目类别:
Research Grant
Photocatalysis for Organic Synthesis
有机合成光催化
- 批准号:
EP/I003800/1 - 财政年份:2010
- 资助金额:
$ 87.95万 - 项目类别:
Research Grant
Bright IDEAS Award: Intelligent pigments and plastics
Bright IDEAS 奖:智能颜料和塑料
- 批准号:
EP/H048170/1 - 财政年份:2010
- 资助金额:
$ 87.95万 - 项目类别:
Research Grant
Nanocrystalline Photodiodes: Novel Devices for Water Splitting
纳米晶光电二极管:新型水分解装置
- 批准号:
EP/F056230/1 - 财政年份:2008
- 资助金额:
$ 87.95万 - 项目类别:
Research Grant
Development of novel, UV-activated, intelligent inks for food packaging
开发用于食品包装的新型紫外线激活智能油墨
- 批准号:
EP/F063725/1 - 财政年份:2008
- 资助金额:
$ 87.95万 - 项目类别:
Research Grant
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