PATHOGENESIS OF ACQUIRED IMMUNE DEFICIENCY SYNDROME

获得性免疫缺陷综合征的发病机制

• 批准号: 3548356
• 负责人: CHARLES HARVEY KIRKPATRICK
• 金额: $ 18.93万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-09-30 至 1986-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3548356
• 关键词: AIDS; T lymphocyte; cancer risk; case history; cell type; communicable disease transmission; disease /disorder model; early diagnosis; helper T lymphocyte; hemophilia As; hepatitis B virus group; homosexuals; immune complex; immunologic assay /test; interferons; interleukin 2; leukocyte activation /transformation; lymphokines; male; secondary infection; semen; serology /serodiagnosis; sperm

The purpose of this investigation is to perform epidemiologic surveys and immunologic tests that will provide information concerning risk factors and will predict persons at risk for the Acquired Immune Deficiency Syndrome (AIDS). The populations under study are 1) asymptomatic homosexual men; 2) homosexual men with the chronic lymphadenopathy syndrome (CLS); 3) homosexual men with and without evidence of hepatitis B virus (HBV) infections; and 4) patients with hemophilia A. The initial studies will establish the incidence and prevalence of AIDS in Denver, Colorado, a community with a large homosexual population that does not yet have residents with AIDS. Subsequent serial studies will identify risk factors and establish the specificity and sensitivity of each immunologic test in the panel. Patients with hemophilia will clarify the role of blood borne transmissible agents in the pathogenesis of AIDS. The possible role of sperm in development of the immuno-deficiency in AIDS will be examined.

本次调查的目的是进行流行病学调查， 免疫学测试将提供有关风险因素的信息， 将预测获得性免疫缺陷综合症的危险人群 （艾滋病）。 研究的人群是1）无症状的同性恋男性; 2） 患有慢性淋巴结病综合征（CLS）的同性恋男性; 3） 有和没有证据表明有B型肝炎病毒（HBV）的男同性恋者 感染;和4）患有血友病A的患者。 初步研究将 建立科罗拉多丹佛艾滋病的发病率和流行率， 一个拥有大量同性恋人口的社区， 艾滋病患者。 随后的系列研究将确定风险因素 并建立每种免疫学试验的特异性和敏感性， 小组。 血友病患者将阐明血液传播的作用 在艾滋病发病机制中的作用。 可能发挥的作用 精子在艾滋病发展中的免疫缺陷将被检查。

项目成果

The significance of antilymphocyte antibodies in patients with acquired immune deficiency syndrome (AIDS) and their sexual partners.

抗淋巴细胞抗体对获得性免疫缺陷综合征（艾滋病）患者及其性伴侣的意义。

• DOI: 10.1007/bf00916007
• 发表时间: 1987
• 期刊: Journal of clinical immunology
• 影响因子: 9.1
• 作者: Ozturk,GE;Kohler,PF;HorsburghJr,CR;Kirkpatrick,CH
• 通讯作者: Kirkpatrick,CH

Interleukin-2 production by persons with the generalized lymphadenopathy syndrome or the acquired immune deficiency syndrome.

患有全身性淋巴结病综合征或获得性免疫缺陷综合征的人会产生白介素 2。

• DOI: 10.1007/bf00915166
• 发表时间: 1985
• 期刊: Journal of clinical immunology
• 影响因子: 9.1
• 作者: Kirkpatrick,CH;Davis,KC;HorsburghJr,CR;Cohn,DL;Penley,K;Judson,FN
• 通讯作者: Judson,FN

The relationship of abnormalities of cellular immunity to antibodies to HTLV-III in homosexual men.

男同性恋者细胞免疫异常与 HTLV-III 抗体的关系。

• DOI: 10.1016/0008-8749(86)90276-5
• 发表时间: 1986
• 期刊: Cellular immunology
• 影响因子: 4.3
• 作者: Dobozin,BS;Judson,FN;Cohn,DL;Penley,KA;Rickmann,PE;Blaser,MJ;Sarin,PS;Weiss,SH;Kirkpatrick,CH
• 通讯作者: Kirkpatrick,CH

Altered immunity in hemophilia correlates with the presence of antibody to human T-cell lymphotropic virus type III (HTLV-III).

血友病中免疫力的改变与人类 T 细胞嗜淋巴细胞病毒 III 型 (HTLV-III) 抗体的存在相关。

• DOI: 10.1007/bf00915362
• 发表时间: 1986
• 期刊: Journal of clinical immunology
• 影响因子: 9.1
• 作者: HorsburghJr,CR;Davis,KC;Hasiba,U;Weiss,SH;Goedert,JJ;Sarin,P;Kirkpatrick,CH
• 通讯作者: Kirkpatrick,CH