AEROBIC EXERCISE AND AGE--METABOLIC, HORMONAL, AND CARDIOVASCULAR RESPONSES

有氧运动与年龄——代谢、荷尔蒙和心血管反应

• 批准号: 3823175
• 负责人: A ZIEMBA
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3823175
• 关键词: aging; cardiovascular function; catecholamines; electrocardiography; exercise; free fatty acids; glucagon; glucose; hormone regulation /control mechanism; human middle age (35-64); insulin; lactates; triglycerides; young adult human (21-34)

Physical working capacity decreases progressively during adult life. Contributing to this decline are decreases in function of the cardiovascular and pulmonary systems as well as a decrease in muscle mass. It is our hypothesis that decreased ability to perform physical work in the elderly is also associated with changes in the hormonal regulation of blood "fuel" regulation during exercise. The purpose of the present study is to examine the effect of age on plasma levels of glucose, free fatty acids (FFA) and of hormones responsible for regulating energy stores (catecholamines, glucagon, insulin) both at rest and during prolonged exercise. Plasma levels of glycerol, triglycerides and lactic acid are also measured. Exercise is accomplished by progressively increasing levels of treadmill walking. Subjects walk for 10 minutes at each of 3 exercise levels, 40, 50 and 60% of their previously determined maximal oxygen consumption (VO2max), and for 30 minutes at 70% of VO2max. Thus, duration of an exercise session is 1 hour. Blood samples for metabolite and hormone determinations are taken before exercise, at the end of each exercise stage, and 15 minutes after its termination. Samples of expired air are obtained before exercise, during the final 2 minutes of each submaximal workload and at the end of the recovery period for measurements of minute ventilation, oxygen consumption, carbon dioxide production, and respiratory quotient. The ECG is monitored continuously during the entire experimental period. Healthy subjects are selected from participants in the Baltimore Longitudinal Study of Aging according to the following criteria: no evidence of cardiovascular or other significant disease, negative treadmill maximal exercise test, no cardioactive medication, no cigarette smoking, non-obese and normotensive. Twenty-four men covering the adult age span have completed the protocol. Results will be analyzed in the coming year. Preliminary results on serum testosterone levels (basal and at the end of exercise) in the first 19 men show that both original levels and responses are highly positively correlated with the level of physical fitness (VO2max) of the participants.

成年后体力工作能力逐渐下降。 造成这种下降的原因是功能的下降 心血管和肺系统以及肌肉质量减少。 我们的假设是，从事体力劳动的能力下降 老年人还与血液荷尔蒙调节的变化有关 运动期间的“燃料”调节。 本研究的目的是 检查年龄对血浆葡萄糖、游离脂肪酸水平的影响 (FFA) 和负责调节能量储存的激素 （儿茶酚胺、胰高血糖素、胰岛素）在休息时和长时间时 锻炼。 甘油、甘油三酯和乳酸的血浆水平为 也测量了。 锻炼是通过逐渐增加水平来完成的 的跑步机行走。 受试者在 3 次练习中每次步行 10 分钟 水平，先前确定的最大氧气含量的 40%、50% 和 60% 最大摄氧量 (VO2max)，并以最大摄氧量 (VO2max) 的 70% 持续 30 分钟。 因此，持续时间 一次锻炼时间为1小时。 代谢物和激素的血液样本 在练习前和每次练习结束时做出决定 阶段，以及结束后15分钟。 呼出气体样本为 在运动前、每个次最大运动的最后 2 分钟内获得 工作量和恢复期结束时的分钟测量 通气量、耗氧量、二氧化碳产生量和呼吸 商。 整个实验过程中持续监测心电图 时期。 健康受试者选自巴尔的摩的参与者 根据以下标准进行纵向老化研究： 否 心血管或其他重大疾病的证据，跑步机阴性 最大运动测试，不服用心脏活性药物，不吸烟， 非肥胖且血压正常。 涵盖成年年龄跨度的二十四名男性 已完成协议。 结果将在来年进行分析。 血清睾酮水平的初步结果（基础和治疗结束时） 练习）在前 19 名男子中表明，原始水平和反应 与身体素质水平呈高度正相关 参与者的（最大摄氧量）。