PHYSICAL ACTIVITY, BODY WEIGHT, AGE, AND CORONARY RISK FACTORS

体力活动、体重、年龄和冠心病风险因素

• 批准号: 3823172
• 负责人: A ZIEMBA
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3823172
• 关键词: aging; blood lipid; blood pressure; body physical activity; body weight; caloric dietary content; coronary disorder; disease /disorder proneness /risk; exercise; glucose tolerance test; health surveys; hyperlipidemia; longitudinal human study; nutrition related tag; physical fitness; questionnaires

Risk factors for coronary artery disease (CAD) include age, metabolic and cardiovascular factors (hyperlipidemia, hyperglycemia, hypertension) and also certain living habits (diet, cigarette smoking, and physical activity level). Overweight is known to be associated with these factors. More recently, the pattern of fat distribution is emerging as an important contributory variable. Data obtained on participants in the Baltimore Longitudinal Study of Aging (BLSA) have been analyzed. The Body Mass Index or BMI (weight/height2) was used as an index of overweight and the waist:hip circumferential ratio (WHR) as a measure of fat distribution pattern. Both bivariate and multiple regression techniques were used to assess interrelationships among the variables designated as "independent" (age, BMI, WHR, and physical activity level) as well as to assess their influence on the variables designated as "dependent" (serum lipid moieties, glucose tolerance, fasting plasma glucose and systolic and diastolic blood pressure). Habitual physical activity level was obtained from detailed activity history questionnaires completed on each visit since 1965 by most participants in the BLSA and maximal aerobic capacity, VO2 max, has been assessed in the past two years. Neither the habitual activity level nor the VO2 max had much independent effect on coronary risk factors except for the serum cholesterol level in men and systolic blood pressure response to exercise in women. Thus, although intensive physical activity can be shown under experimental laboratory conditions to alter many coronary risk factors in a favorable direction, in this study of a free-living population the effect of activity is minimal. These surprisingly negative results might be explained if physical activity exerts its effects in this population by acting on body weight, so that it loses its independent significance on multivariate analysis.

冠状动脉疾病（CAD）的危险因素包括年龄、代谢和 心血管因素（高脂血症、高血糖症、高血压）和 还有某些生活习惯（饮食、吸烟和体育活动 水平）。 众所周知，超重与这些因素有关。 更 最近，脂肪分布的模式正在成为一个重要的 贡献变量 在巴尔的摩获得的参与者数据 对老年人纵向研究（BLSA）进行了分析。 体重指数 或BMI（体重/身高2）被用作超重指数， 腰围：臀围比（WHR）作为脂肪分布的量度 格局 二元和多元回归技术被用来 评估指定为“独立”的变量之间的相互关系 (age，BMI，WHR和身体活动水平）以及评估他们的 对指定为“依赖性”的变量的影响（血清脂质部分， 葡萄糖耐量、空腹血糖、收缩压和舒张压 压力）。 习惯性体力活动水平从详细的 自1965年以来，大多数人在每次访问时完成的活动历史问卷 参与者在BLSA和最大有氧能力，VO 2最大，已被 在过去的两年里，评估。 无论是日常活动水平， 最大摄氧量对冠心病危险因素的独立影响， 男性血清胆固醇水平和收缩压对 锻炼女性。 因此，虽然密集的体力活动可以显示， 在实验室条件下， 在这项对自由生活人口的研究中， 活动的影响是最小的。 这些令人惊讶的负面结果 可以解释，如果体力活动发挥其影响，在这一点上， 人口通过作用于体重，使其失去了独立的 多变量分析的意义。