实验大鼠门静脉和肝静脉插管-猫眼课题宝

实验大鼠门静脉和肝静脉插管

批准号：

3822947

负责人：

M-T HUANG

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3822947

关键词：

alcohol dehydrogenase detoxification dietary carbohydrates ethanol gastrointestinal nutrient absorption glucose metabolism liver circulation liver function liver metabolism nutrition related tag oxidation reduction reaction portal vein

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英文摘要

A surgical method was developed to cannulate chronically both the portal and hepatic veins of laboratory rats. This experimental system is useful for studies on intestinal absorption and hepatic extractions of nutrients. With this experimental system, the following objectives can be determined (1) the effect of dietary carbohydrate on the elimination of ethanol and (2) glucose paradox. In the first study, the rate of ethanol elimination will be determined in rats meal-fed with diet containing glucose, fructose, mixture of glucose and fructose, and sucrose to determine the importance of alcohol dehydrogenase and redox state in liver on the metabolism of ethanol in vivo. In the second study, portal-hepatic difference of glucose and gluconeogenetic precursors will be determined in order to resolve the paradox that liver can not utilize glucose efficiently.

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