Terahertz Lab-on-a-Chip for Bio-liquid Analysis

用于生物液体分析的太赫兹芯片实验室

• 批准号: EP/V001655/1
• 负责人: Stephen Hanham
• 金额: $ 40.19万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FV001655%2F1
• 关键词: Terahertz; Lab; Chip; Bio; liquid

There is an increasing global demand for new technologies which deliver rapid and accurate medical diagnostics and lead to improved patient outcomes. The biological sensors field has grown dramatically to meet this demand, aided by significant improvements in microfluidics and microelectronics. This revolution in micro-technology has led to the realisation of biological sensors in the form of a lab-on-a-chip (LOC) that can perform one or more lab analyses of minute quantities of liquid samples on a single chip. This analysis can take many different forms such as chemical, acoustic, low-frequency electrical or optical.The terahertz frequency range (100 GHz to 3 THz) is an emerging area for the electromagnetic analysis of biological systems. For biological liquids, it is capable of probing rotational and vibrational modes present in biomolecule-solvent systems and is also highly sensitive to biomolecular hydration, temperature, binding and conformational states. Despite these significant advantages for sensing, terahertz waves suffer from a relatively long wavelength which limits the smallest detectable object or liquid volume that can be sensed to a size comparable to a wavelength cubed. This size limit, called the diffraction limit, is significantly larger than many objects of interest such as a biological cell.In this work, we propose to integrate multiple terahertz resonators with a microfluidic system to create a LOC capable of rapidly sensing free-flowing bio-liquids. The resonators are designed to concentrate the measuring electric field down to a volume comparable to a cell size, overcoming the diffraction limit, and permitting the electromagnetic analysis of picolitre quantities of biological liquids and individual cells. This LOC will function as a measurement platform for scientific studies of cells, extremely small quantities of various cell components (e.g. proteins, DNA and RNA) and other biomolecules of interest.The research programme intends to push the current state-of-the-art in terahertz liquid sensing in terms of sensitivity (10x), minimum sample volume and low-cost fabrication to open up new sensing and diagnostic opportunities in point-of-care diagnosis and clinical applications. While primarily directed towards the analysis of bio-liquids, the lab-on-a-chip devices developed will also prove useful for the analysis of toxic and explosive liquids, as well as gas sensing.

全球对新技术的需求不断增长，这些新技术提供了快速，准确的医学诊断，并改善了患者的结果。生物传感器领域已经急剧增长以满足这一需求，这是在微流体和微电子学的显着改善的帮助下。微技术的这一革命导致以实验室（LOC）的形式实现了生物传感器，该传感器可以在单个芯片上执行一种或多种实验室分析。该分析可以采取许多不同的形式，例如化学，声学，低频电或光学。Terahertz频率范围（100 GHz至3 THz）是生物系统电磁分析的新兴区域。对于生物液体，它能够探测生物分子溶剂系统中存在的旋转和振动模式，并且对生物分子水合，温度，结合和构象状态也高度敏感。尽管传感具有这些显着优势，但Terahertz波却具有相对较长的波长，该波长限制了最小的可检测物体或液体体积，可以将其感应到与波长近距离的大小相当。这种尺寸极限（称为衍射极限）明显大于许多感兴趣的对象，例如生物细胞。在这项工作中，我们建议将多个Terahertz共振器与微流体系统整合在一起，以创建能够快速感知自由流动的生物液体的LOC。谐振器旨在将测量电场集中到与细胞大小相当的体积，克服衍射极限，并允许对Picolitre量的生物液体和单个细胞的电磁分析。该LOC将充当细胞科学研究的测量平台，大量的各种细胞成分（例如蛋白质，DNA和RNA）以及其他感兴趣的生物分子。该研究计划旨在在Terahertz液体液体敏感性（10x）的临床上，最小诊断的临床临床，临床临床的最低诊断，临床临床的临床临床，并将其开放的临床临床（10X），最低临床诊断，并将其开放，以诊断最低诊断，并开放诊断，并将其临床诊断为临床，并进行诊断的新临床。申请。虽然主要针对生物液体的分析，但开发的实验室设备也将被证明可用于分析有毒和爆炸性液体以及气体传感。

项目成果

Novel mm-Wave Oscillator Based on an Electromagnetic Bandgap Resonator

基于电磁带隙谐振器的新型毫米波振荡器

• DOI: 10.1109/lmwt.2023.3268090
• 发表时间: 2023
• 期刊: IEEE Microwave and Wireless Technology Letters
• 作者: Lia E

Hyperspectral terahertz imaging for human bone biometrics

用于人体骨骼生物识别的高光谱太赫兹成像

• DOI: 10.1117/12.2595921
• 发表时间: 2021
• 作者: Freer S

Temperature dependent hyperspectral terahertz imaging of human bone for disease diagnosis

用于疾病诊断的人体骨骼温度依赖性高光谱太赫兹成像

• DOI: 10.1117/12.2610249
• 发表时间: 2022
• 作者: Freer S

Hybrid reflection retrieval method for terahertz dielectric imaging of human bone.

• DOI: 10.1364/boe.427648
• 发表时间: 2021-08-01
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Freer S;Sui C;Hanham SM;Grover LM;Navarro-Cía M
• 通讯作者: Navarro-Cía M

Silica Nanoparticle-Based Photoresin for THz High-Resolution 3-D Microfabrication by Two-Photon Polymerization

• DOI: 10.1109/tthz.2023.3275282
• 发表时间: 2023-07
• 期刊: IEEE Transactions on Terahertz Science and Technology
• 影响因子: 3.2
• 作者: Emil John Y. Magaway;Yeganeh Farahi;S. Hanham;Z. Zhang;Adriana Guaidía-Moreno;M. Navarro‐Cía