BEHAVIOR FACTORS IN BLOOD PRESSURE REGULATION

饮食和行为因素与糖尿病的发生有关。 通过流行病学研究发现原发性高血压，但 这些因子独立存在的病理生理机制 或协同作用，影响长期血压调节尚待进一步研究 澄清了。动物研究表明，高钠摄入量会导致 持续高血压当且仅当受试者同时暴露于 反复出现的行为压力。 本项目提出的假设是神经内分泌因子， 其中改变钠调节的是在行为条件下被激活的 压力，当与高钠摄入量相结合时，会导致 血压。在第一项研究中，医科学生摄入了 每天服用氯化钠或安慰剂片剂，持续两周 考试前和暑期的两个星期。高潮 考试准备期间的钠摄入量与 与高钠相比，收缩压和平均血压的增加更大 夏季摄入量和准备期间通常的钠摄入量 句号。状态焦虑与血液变化显著相关 高钠组观察到的压力。第二项研究是 旨在复制高血压的收缩压和平均压效应 备考条件下的钠摄入量。尿液排泄数据 均已获得，并表明符合钠操纵。 采集血清中钠泵循环抑制物检测结果分析 在备考期间正在进行中。结果是 与行为压力和钠摄入量 对长期的血压调节有协同作用。

Dietary and behavioral factors have been implicated in the development of primary hypertension through epidemiological studies, but the pathophysiological mechanisms by which these factors, either independently or synergistically, affect long-term blood pressure regulation remain to be clarified. Animal studies have shown that high sodium intake engenders sustained hypertension if, and only if, the subject is concurrently exposed to recurrent behavioral stress. The present project addresses the hypothesis that neuroendocrine factors, which alter sodium regulation are activated under conditions of behavioral stress and, when combined with a high sodium intake, result in elevated blood pressure. In the first study, medical students consumed either sodium chloride or placebo tablets daily for two weeks immediately preceding examinations and for two weeks during the summer. The high sodium intake during the exam preparation period was associated with greater increases in systolic and mean blood pressure than the high sodium intake during the summer and the usual sodium intake during the preparation period. State anxiety was significantly related to the changes in blood pressure observed in the high sodium group. A second study has been designed to replicate the systolic and mean pressure effects of the high sodium intake under conditions of exam preparation. Urinary excretion data were obtained and indicate compliance with the sodium manipulation. Analysis for circulating inhibitors of the sodium pump in serum collected during the exam preparation period is in progress. The results are consistent with the hypothesis that behavioral stress and sodium intake have synergistic effects on long-term blood pressure regulation.