RESPIRATORY FACTORS IN BLOOD PRESSURE REGULATION

高血压的发展是协同作用的结果 高钠摄入与行为因素之间的相互作用，但 其调节生理机制尚待阐明。一个 高血压的动物模型表明钠敏感性可能是 受厌恶者引起的呼吸模式的影响 条件反射程序。以往对门诊的研究 呼吸监测仪显示低频率/正常发作 潮气量呼吸可以在人体内观察到。 环境。正在进行的人类受试者实验室研究包括 表明抑制性呼吸模式伴随着 二氧化碳分压升高，pH降低，肾脏钠升高 重吸收，内源性洋地黄尿液排泄增加- 同样的因素，钠泵活性降低，而 血压，但不是心率。这种生理模式 为交感神经系统提供了另一种选择 行为因素与高钠相互作用的机制 在实验动物中产生持续性高血压的摄入量 人类。这些研究可能导致非药物干预 预防和逆转高血压及相关疾病 衰老。

The development of hypertension is potentiated by synergistic interactions between high sodium intake and behavioral factors, but the mediating physiological mechanisms remain to be clarified. An animal model of hypertension suggests that sodium sensitivity may be influenced by a hypoventilatory breathing pattern evoked by aversive conditioning procedures. Previous studies with an ambulatory respiration monitor have shown that episodes of low frequency/normal tidal volume breathing can be observed in humans in the natural environment. Ongoing laboratory studies with human subjects are showing that the inhibitory breathing pattern is accompanied by increases in pCO2, decreases in pH, increases in renal sodium reabsorption, increases in urinary excretion of endogenous digitalis- like factors, decreases in sodium pump activity, and increases in blood pressure, but not heart rate. This physiological pattern provides an alternative to the sympathetic nervous system as a mechanism whereby behavioral factors may interact with high sodium intake to produce sustained hypertension in laboratory animals and humans. These studies may lead to nonpharmacological interventions for prevention and reversal of hypertension and associated disorders of aging.