AGE EFFECTS ON BLOOD PRESSURE AND CIRCULATING SODIUM-PUMP INHIBITORS

流行病学研究表明，平均血压和 高血压患病率均随年龄增长而增加。一个可能的角色是 饮食中钠摄入量在增龄时血压升高 个人已被记录在案，但可获得的信息很少 关于循环荷尔蒙可能与年龄相关的变化 影响钠跨血管平滑肌的运输。现在 这项研究评估了两种循环水平的个体差异 钠泵抑制激素作为年龄相关性变化的预测因子 在静息血压中。早晨仰卧位血压和 巴尔的摩检测到内源性哇巴因和洋地黄样因子 符合纳入条件的老年参与者的纵向研究 标准。这项研究还调查了可能的差异 循环钠泵抑制剂与种族和性别的关系。 数据支持这一假设，即 静息血压和循环钠泵抑制剂可能 导致药理学和非药理学干预 关注钠泵抑制剂及其决定因素的高血压。

Epidemiological studies have shown that mean blood pressure and the prevalence of hypertension both increase with age. A possible role for dietary sodium intake in the blood pressure increase in aging individuals has been documented, but little information is available concerning possible age-associated changes in circulating hormones that affect sodium transport across vascular smooth muscle. The present study assesses individual differences in levels of two circulating sodium-pump inhibiting hormones as predictors of age-associated changes in resting blood pressure. Morning supine blood pressure and endogenous ouabain and digitalis-like factor are measured in Baltimore Longitudinal Study on Aging participants who meet the inclusion criteria. The study also investigates possible differences in circulating sodium-pump inhibitors as a function of race and gender. Data supporting the hypothesis of a positive correlation between resting blood pressure and circulating sodium-pump inhibitors could lead to pharmacological and nonpharmacological intervention in hypertension focusing on sodium-pump inhibitors and their determinants.