AGE EFFECTS ON BLOOD PRESSURE AND CIRCULATING SODIUM-PUMP INHIBITORS

流行病学研究表明，平均血压和 高血压患病率均随年龄增长而增加。一个可能的角色是 膳食钠摄入量对老年个体血压的影响 已经被记录在案，但几乎没有关于 影响钠的循环激素可能与年龄相关的变化 通过血管平滑肌运输。本研究评估 两种循环钠泵抑制水平的个体差异 激素作为与年龄相关的静息血压变化的预测因子。 晨仰卧位血压与内源性哇巴因和洋地黄样物质 将在巴尔的摩纵向研究的参与者中衡量这一因素 关于年龄符合纳入标准的问题。该研究还调查了 循环钠泵抑制剂的可能差异作为以下因素的函数 种族和性别。支持正相关假说的数据 在静息血压和循环钠泵抑制剂之间可能 导致高血压的药物干预和非药物干预 重点研究这两种钠泵抑制剂中的一种或两种 决定因素。

Epidemiological studies have shown that mean blood pressure and the prevalence of hypertension both increase with age. A possible role for dietary sodium intake in the blood pressure increase in aging individuals has been documented, but little information is available concerning possible age-associated changes in circulating hormones that affect sodium transport across vascular smooth muscle. The present study assesses individual differences in levels of two circulating sodium-pump inhibiting hormones as predictors of age-associated changes in resting blood pressure. Morning supine blood pressure and endogenous ouabain and digitalis-like factor will be measured in participants in the Baltimore Longitudinal Study on Aging meeting the inclusion criteria. The study also investigates possible differences in circulating sodium-pump inhibitors as a function of race and gender. Data supporting the hypothesis of a positive correlation between resting blood pressure and circulating sodium-pump inhibitors could lead to pharmacological and nonpharmacological intervention in hypertension focusing on either or both of these sodium-pump inhibitors and their determinants.