BEHAVIOR FACTORS IN BLOOD PRESSURE REGULATION

膳食氯化钠在原发性高血压发病机制中的作用 高血压一直是个谜。洞察其可能的贡献 可能是在动物研究中提供的，这些研究表明高钠摄入量 如果且仅当受试者是 同时暴露在反复的行为压力之下。因此， 目前的项目解决了这样的假设，即高钠摄入量将 使人类血压升高，但仅在特定的测谎压力下 与神经内分泌介导的钠效应相关的条件 监管。目前正在对医科学生进行初步研究 立即保持高钠饮食或安慰剂两周 在期末考试之前。初步结果显示，静息血液 在科目考试前的两周内，压力有所增加 高钠饮食，但不服用安慰剂。此外，受试者在 高钠组报告感觉到的压力和状态焦虑的变化 它们与压强的大小显著相关 立面。这些结果与假设是一致的 压力和盐摄入量的交互作用对 长期调节血压，并为进一步 调节生理和细胞因子的研究。

The role of dietary sodium chloride in the pathogenesis of primary hypertension has remained enigmatic. Insight into its possible contribution may be provided in animal studies which have shown that high sodium intake engenders sustained hypertension if, and only if, the subject is concurrently exposed to recurrent behavioral stress. Accordingly, the present project addresses the hypothesis that a high sodium intake will elevate blood pressure in humans, but only under specific lie stress conditions associated with neuroendocrine-mediated effects on sodium regulation. An initial study is being conducted with medical students maintained on a high sodium diet or placebo for two weeks immediately preceding their final exams. Preliminary results show that resting blood pressure increased during the two weeks prior to examinations in subjects on a high sodium diet but not on the placebo. In addition, subjects in the high sodium group reported changes in perceived stress and state anxiety which were significantly correlated with the magnitude of pressure elevation. These results are consistent with the hypothesis that interactions of stress and salt intake have significant effects on long-term blood pressure regulation, and provide a basis for further investigation of mediating physiological and cellular factors.