SUrfaCe Characteristics Enabled StrategieS against virus transmission (SUCCESS)

表面特征启用病毒传播策略（成功）

• 批准号: EP/V029762/1
• 负责人: Zhenyu Zhang
• 金额: $ 82.76万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FV029762%2F1
• 关键词: SUrfaCe; Characteristics; Enabled; StrategieS; against

We propose to mitigate the transmission of COVID-19 between humans by development of antiviral formulated products. It will be delivered via additives in domestic formulated products, e.g. spray or aerosol, or integrated with current manufacturing processes, forming an invisible and long-lasting film of sub-micron thickness. Unlike disinfectants, formulations will be designed to both capture the aerosol droplets and inactivate the virus.Our first priority is to establish a mechanistic understanding of the interactions between aerosol droplets (or pure virus particles) and surfaces, which will inform possible antiviral mechanisms while providing a set of fundamental and coherent design principles for antiviral surfaces.Two technology platforms will be pursued to leverage the expertise and capability of our industrial partners. Polymer additives with controlled chemistry and molecular architecture will be explored to generate molecular films that facilitate disruption of aerosolised droplets and which may rupture the viral envelope or interfere adversely with key viral proteins and or genetic material. Proposed nanocellulose additives will confer additional benefits in terms of providing a porous structure designed to wick and absorb any protective mucus present.In parallel, hybrid polymer technology will be developed, employing reactive oxygen-producing copper nanoparticles coupled with flavin dyes that produce singlet oxygen species known to deactivate viruses when irradiated with light of the appropriate wavelength.Upon satisfactory antiviral testing results, promising design/formulation will be recommended based on their processability, suitability for end-applications, and environmental impact. Industrial partners with substantial experience in formulation will carry out pilot-scale production and full- scale manufacturing subsequently.

我们建议通过开发抗病毒配方产品来减少COVID-19在人类之间的传播。它将通过添加剂在国内配制的产品，如喷雾或气雾剂，或与目前的制造工艺相结合，形成一个无形的和持久的亚微米厚度的薄膜。与消毒剂不同的是，我们设计的配方既能捕获气溶胶液滴，又能杀灭病毒。我们的首要任务是建立对气溶胶液滴之间相互作用的机理理解（或纯病毒颗粒）和表面，这将为可能的抗病毒机制提供信息，同时为抗病毒表面提供一套基本和一致的设计原则。将追求两个技术平台，以利用专业知识，我们的工业合作伙伴的能力。将探索具有受控化学和分子结构的聚合物添加剂，以产生分子膜，其促进雾化液滴的破坏，并且可能破坏病毒包膜或不利地干扰关键病毒蛋白质和/或遗传物质。建议的纳米纤维素添加剂将提供额外的好处，在提供一个多孔结构，旨在芯吸和吸收任何保护粘液存在。同时，混合聚合物技术将开发，采用活性氧产生铜纳米粒子耦合黄素染料，产生单线态氧物种已知灭活病毒时，用适当波长的光照射。在令人满意的抗病毒测试结果，将根据其加工性能、最终应用的适用性和环境影响推荐有前途的设计/配方。在配方方面具有丰富经验的工业合作伙伴将随后进行中试规模生产和全面生产。

项目成果

Tuning Riboflavin Derivatives for Photodynamic Inactivation of Pathogens

调整核黄素衍生物以光动力灭活病原体

• DOI: 10.21203/rs.3.rs-1111998/v2
• 发表时间: 2022
• 作者: Fruk L

Molecular Understanding of Fouling Induction and Removal: Effect of the Interface Temperature on Milk Deposits.

• DOI: 10.1021/acsami.1c09553
• 发表时间: 2021-08-04
• 期刊: ACS applied materials & interfaces
• 影响因子: 9.5
• 作者: Avila-Sierra A;Huellemeier HA;Zhang ZJ;Heldman DR;Fryer PJ
• 通讯作者: Fryer PJ

Tuning riboflavin derivatives for photodynamic inactivation of pathogens.

• DOI: 10.1038/s41598-022-10394-7
• 发表时间: 2022-04-21
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Crocker, Leander B.;Lee, Ju Hyun;Mital, Suraj;Mills, Gabrielle C.;Schack, Sina;Bistrovic-Popov, Andrea;Franck, Christoph O.;Mela, Ioanna;Kaminski, Clemens F.;Christie, Graham;Fruk, Ljiljana
• 通讯作者: Fruk, Ljiljana

Characteristics of Respiratory Microdroplet Nuclei on Common Substrates

常见基质上呼吸微滴核的特征

• DOI: 10.48550/arxiv.2105.10024
• 发表时间: 2021
• 作者: Kosmidis-Papadimitriou A

Quantifying the Mechanical Properties of Yeast Candida albicans Using Atomic Force Microscopy-based Force Spectroscopy.

使用基于原子力显微镜的力谱定量酵母白色念珠菌的机械特性。

• DOI: 10.1007/978-1-0716-3199-7_1
• 发表时间: 2023
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Jones CR