MIRDP AT XAVIER UNIVERSITY OF LOUISIANA

本申请建议酒精、药物滥用和精神健康 (ADM)将增强我们机构能力的研究项目 开展ADM研究。这项建议的目标是： 1.加强制度基础设施建设。 2.提高教职员工个人的工作能力 ADM研究。 3.让优秀学生参与研究，以鼓励 他们追求ADM研究的职业生涯。 (-)-可卡因的三维结构和电子性质 和(-)-去甲可卡因将被检测出来。通常情况下， 将对可卡因的肝脏毒性进行处方药调查 在小鼠模型中。中枢苯二氮卓类的内源性配体 受体将被识别出来。这种内源性配体对血管内皮生长因子的影响 将确定突触神经体对GABA门控氯的摄取。 将合成新的抗艾滋病药物类似物以预防和治疗 艾滋病对心理健康的影响。生物利用度、代谢和 这些新药的血脑分布将被确定。小说 肝毒性较小的抗卡氏肺孢子虫药物将 合成使酗酒艾滋病患者的药物治疗得以改进 肝脏受损。抗艾滋病药物与药物的药代动力学相互作用 将研究抗卡氏肺孢子虫的药物。最后，它的影响 慢性饮酒对卡氏肺孢子虫形态的影响 在大鼠模型中将被确定。

The present application proposes Alcohol, Drug Abuse and Mental Health (ADM) research projects that will enhance the ability of our institution to conduct ADM research. The objectives of this proposal are: 1. To strengthen the institutional infrastructure. 2. To enhance the capability of individual faculty members to perform ADM research. 3. To involve outstanding students in research in order to encourage them to pursue careers in ADM research. The three-dimensional structure and electronic character of (-)-cocaine and (-)-norcocaine will be determined. The effect of commonly prescribed drugs on the hepatotoxicity of cocaine will be investigated in a mouse model. An endogenous ligand of the central benzodiazepine receptor will be identified. The effect of this endogenous ligand on GABA-gated chloride uptake into synaptoneurosomes will be determined. New analogs of anti-AIDS drugs will be synthesized to prevent and treat the mental health effects of AIDS. The bioavailability, metabolic, and blood-brain distribution of these new drugs will be determined. Novel anti-Pneumocystis carinii drugs with less hepatotoxicity will be synthesized to enable improved drug therapy of alcoholic AIDS patients with liver damage. Pharmacokinetic interactions between anti-AIDS and anti-Pneumocystis carinii drugs will be studied. Finally, the effects of chronic alcohol consumption on the appearance of Pneumocystis carinii in a rat model will be determined.