MIRDP AT XAVIER UNIVERSITY OF LOUISIANA

本申请提出了酒精、药物滥用和精神健康 (ADM)研究项目，这将提高我们的机构的能力 进行ADM研究。 这项建议的目标是： 1. 加强体制基础设施。 2. 提高教师个人的表演能力 ADM研究 3. 让优秀学生参与研究，以鼓励 他们追求事业在ADM研究。 （-）-可卡因的三维结构和电子性质 和（-）-去甲可卡因。 一般的效果 将研究处方药物对可卡因肝毒性的影响 在小鼠模型中。 中枢苯二氮卓类药物的内源性配体 受体将被识别。 这种内源性配体对 将测定GABA门控氯离子摄取到突触神经体中。 将合成新的抗艾滋病药物类似物， 艾滋病对心理健康的影响 生物利用度、代谢和 将确定这些新药的血脑分布。 小说 肝毒性较小的抗卡氏肺孢子虫药物将 以改善酒精中毒艾滋病患者的药物治疗 肝损伤 抗艾滋病药物与 研究抗卡氏肺孢子虫的药物。 最后，影响 慢性饮酒对卡氏肺孢子虫外观的影响 在大鼠模型中，将被确定。

The present application proposes Alcohol, Drug Abuse and Mental Health (ADM) research projects that will enhance the ability of our institution to conduct ADM research. The objectives of this proposal are: 1. To strengthen the institutional infrastructure. 2. To enhance the capability of individual faculty members to perform ADM research. 3. To involve outstanding students in research in order to encourage them to pursue careers in ADM research. The three-dimensional structure and electronic character of (-)-cocaine and (-)-norcocaine will be determined. The effect of commonly prescribed drugs on the hepatotoxicity of cocaine will be investigated in a mouse model. An endogenous ligand of the central benzodiazepine receptor will be identified. The effect of this endogenous ligand on GABA-gated chloride uptake into synaptoneurosomes will be determined. New analogs of anti-AIDS drugs will be synthesized to prevent and treat the mental health effects of AIDS. The bioavailability, metabolic, and blood-brain distribution of these new drugs will be determined. Novel anti-Pneumocystis carinii drugs with less hepatotoxicity will be synthesized to enable improved drug therapy of alcoholic AIDS patients with liver damage. Pharmacokinetic interactions between anti-AIDS and anti-Pneumocystis carinii drugs will be studied. Finally, the effects of chronic alcohol consumption on the appearance of Pneumocystis carinii in a rat model will be determined.